DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABCB7 and Mdr50

DIOPT Version :9

Sequence 1:	NP_728642.2	Gene:	ABCB7 / 38193	FlyBaseID:	FBgn0035244	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_523740.3	Gene:	Mdr50 / 36582	FlyBaseID:	FBgn0010241	Length:	1313	Species:	Drosophila melanogaster

Alignment Length:	555	Identity:	172/555 - (30%)
Similarity:	260/555 - (46%)	Gaps:	72/555 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   227 FAKVAHHSIRKIASNVFLHLHNLDLAFHLNKQTGA--------LSKTID-RGSRGINFV--LSAM 280
            |...||..|..|.|..|..:.:.|:.::...|:|.        |||..| ...:.:.||  |.|.
  Fly   168 FNYAAHSQILTIRSKFFRSILHQDMKWYDFNQSGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAF 232

  Fly   281 VFNIVPTIFELALVSS-ILGVKC--GLAFAGVSMGCVGIYAAYTLSVTQWRTQFRVFMNQAENEA 342
            |.::|     ||.|.. .|.:.|  .|....::||.|.:..:            |:...:....|
  Fly   233 VGSLV-----LAFVKGWQLSLVCLTSLPLTFIAMGLVAVATS------------RLAKKEVTMYA 280

  Fly   343 GNKAV--DSLINYETVKYFNNEKYEAGCYNEVLKKYEAASLKTSSSLALLNFGQNAIF---SSAL 402
            |...|  .:|....|||.|..|..|...|.|.:...:..::| .:..:.:.||....|   |.||
  Fly   281 GAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKILNIK-RNMFSGIGFGLLWFFIYASYAL 344

  Fly   403 SL-----IMVLAAKEIAQGNMTVGDLVMVNALLFQLSIPLGFLGSVYREVRQALLDMRAMFTLMN 462
            :.     :::....|.|..|...|.::.|...:...|:.:|...........|......:|.::.
  Fly   345 AFWYGVGLVIKGYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAKGACAKVFHIIE 409

  Fly   463 VDSSIQTAANA-----QPLFVDTTNSSIEFRNVSFEYEPGKP---IFRDLSFTIPAGKNVAIVGG 519
            ....|......     :||      ::|||:.|.|:| |.:|   |...|:..|..|:.||:||.
  Fly   410 QIPEINPIDGEGKKLNEPL------TTIEFKEVEFQY-PTRPEVSILNKLNLKIHRGQTVALVGP 467

  Fly   520 SGSGKSSMVRLLFRFFEPNSGKVLIGGQDISAVDLESLRKVIAVVPQDSVLFHNTIEHNIHYGNL 584
            ||.|||:.::|:.||::|.:|.:|..|.::..:|:..||..|.||.|:.:||..:|..||.||..
  Fly   468 SGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYGRE 532

  Fly   585 SKSHAEVQNAARMADLHDSIMSWPGQYSTQVGERGLKLSGGEKQRVAIARAILKNTPILIFDEAT 649
            ..:..|::.||..|:....|...|..|.|.|||||.:||||:|||:|||||::::..||:.||||
  Fly   533 DATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEAT 597

  Fly   650 SSLDSITEHNILQALTRATSGRTSICIAHRLSTVKDADEILVLENGRVGERGTHSELLRQNGLYA 714
            |:||:.:|..:..||.:.::|||:|.:|||||||:.||.|:|:..|.|.|.|||.||:.....|.
  Fly   598 SALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYF 662

  Fly   715 RLWETQT---------------QQFDPSREINEEV 734
            .|..||.               :.||...|..||:
  Fly   663 NLVTTQLGEDDGSVLSPTGDIYKNFDIKDEDEEEI 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABCB7	NP_728642.2	ABC_membrane	164..437	CDD:294371	55/233 (24%)
		ATM1	222..717	CDD:227590	164/521 (31%)
		P-loop_NTPase	485..720	CDD:304359	104/237 (44%)
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	172/555 (31%)
		ABC_membrane	92..382	CDD:279056	54/231 (23%)
		ABC_MTABC3_MDL1_MDL2	431..668	CDD:213216	104/237 (44%)
		ABC_membrane	750..1020	CDD:279056
		ABC_MTABC3_MDL1_MDL2	1070..1309	CDD:213216
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24221
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010