DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABCB7 and CG3156

DIOPT Version :9

Sequence 1:	NP_728642.2	Gene:	ABCB7 / 38193	FlyBaseID:	FBgn0035244	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_569844.2	Gene:	CG3156 / 30994	FlyBaseID:	FBgn0023536	Length:	692	Species:	Drosophila melanogaster

Alignment Length:	765	Identity:	204/765 - (26%)
Similarity:	328/765 - (42%)	Gaps:	142/765 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LHLTKQCSIHLPA----HLGRAKCYTLAKGPGTHVQARVLYSSLTKVDDKNSSDAKRKKITPFTP 65
            |.:.|...|.|..    ||||  |.       .|..||.|..||...:..:|      .:.|...
  Fly    15 LRVRKSSQIRLSTSYNHHLGR--CL-------HHRTARSLQHSLPPPNRYHS------HLHPTLR 64

  Fly    66 TP----------GSKLLGGVFGKKAKGGAPAAAAAKTTTLQRQRPYRPQQQQSRLCHVHIGGG-- 118
            .|          .||.|    .:.||...|.|                           :|.|
  Fly    65 MPWWCMRRGFAQSSKWL----ARNAKANLPTA---------------------------VGAGIV 98

  Fly   119 ----SDGGSGLGKLDAPEVTSKDMLRAMMAYIWPKEDPLVRKRVGISLGLLAGSKLLTVCVPFLF 179
                ..|.|..|:|.:...:.|.:|.|                   .:|.|..|..:|:.||...
  Fly    99 PAPVKMGRSQYGRLLSLTKSEKWVLTA-------------------GIGCLVVSSAITMSVPLFL 144

  Fly   180 KGAVDTM-TTLNMDTAPDAVLSAATALMLGYGIARASAAGF-NELRNAVFAKVAHHSIRKIASNV 242
            ...:|.: ....||:|..|.|...:.|:.|..:    ..|| |..|..:|...|...:|.:.|.:
  Fly   145 GKVIDVVFNKSGMDSAAMAKLGEYSVLLFGIFV----LGGFANFARVHLFGNAALRIVRSLRSRL 205

  Fly   243 FLHLHNLDLAFHLNKQTG---------------ALSKTIDRGSRGINFV---LSAMVFNIVPTIF 289
            :..:...::.:...|.||               :||:.:..|.|.:..:   ...|::    |..
  Fly   206 YRSMLMQEVGWFDTKGTGELINRLSNDTLMVGTSLSQNVSDGLRSVAMIGVGTGMMIY----TSP 266

  Fly   290 ELALVSSILGVKCGLAFAGVSMGCVGIYAAYTLSVTQWR-TQFRVFMNQAENEAGNKAVDSLINY 353
            :||.||:::..    |.||:::    :|..|...:|:.. .::...|..||...|        |.
  Fly   267 QLAAVSALVVP----AMAGMAI----VYGRYVRRITKVELDKYAEIMKFAEERFG--------NV 315

  Fly   354 ETVKYFNNEKYEAGCYNEVLKKYEAASLKTSSSLALLNFGQNAIFSSALSLIMVL--AAKEIAQG 416
            :|||.|..|:.|...::..|.:......|.:.:.|:. ||... |.....:|.||  ....:.|.
  Fly   316 KTVKTFCREQQEVAAFDGKLDEALQIGYKETRARAIF-FGLTG-FCGNFIIISVLYYGGTLVLQD 378

  Fly   417 NMTVGDLVMVNALLFQLSIPLGFLGSVYREVRQALLDMRAMFTLMNVDSSIQTAANAQPLFVDTT 481
            ::|:|.|.........::|.:..|.:.|.::.:.:.....::.:::.:.||.......||  :..
  Fly   379 SLTIGALTAFMLYAGYVAISMNGLSNFYSQLNKGIGASERIWEILDRECSIPIDKGVVPL--EKP 441

  Fly   482 NSSIEFRNVSFEY--EPGKPIFRDLSFTIPAGKNVAIVGGSGSGKSSMVRLLFRFFEPNSGKVLI 544
            ...:.|:||.|.:  .|...:..|.|..:..|...|:||.|||||:::..|:.|.::|..|.|.:
  Fly   442 VGEVGFQNVFFTFPTRPESAVLTDFSLNLMPGTTTAVVGRSGSGKTTIALLMLRLYDPQGGTVHL 506

  Fly   545 GGQDISAVDLESLRKVIAVVPQDSVLFHNTIEHNIHYG---NLSKSHAEVQNAARMADLHDSIMS 606
            .|.|:..|:.:.||..|..|.|:.|||..:|..||.||   ..:.|...:|.....|::......
  Fly   507 DGIDLRTVNPQWLRNNIGAVSQEPVLFSCSIRENILYGANPGETPSPERLQQVIEDANVSQFTDQ 571

  Fly   607 WPGQYSTQVGERGLKLSGGEKQRVAIARAILKNTPILIFDEATSSLDSITEHNILQALTRATSGR 671
            .|....|.||:||:.||||:|||||||||::||..|||.|||||:||:::|:.:..||.....||
  Fly   572 LPDGLDTLVGQRGMMLSGGQKQRVAIARALIKNPAILILDEATSALDAVSENLVQNALDNLIQGR 636

  Fly   672 TSICIAHRLSTVKDADEILVLENGRVGERGTHSELLR-QNGLYARLWETQ 720
            |.:.|||||||:::||:|.||.:|::.|:|:::||:. |.|::..|..:|
  Fly   637 TVLTIAHRLSTIRNADQIAVLSDGKIVEQGSYNELMGIQEGVFRELVASQ 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABCB7	NP_728642.2	ABC_membrane	164..437	CDD:294371	65/295 (22%)
		ATM1	222..717	CDD:227590	151/521 (29%)
		P-loop_NTPase	485..720	CDD:304359	97/240 (40%)
CG3156	NP_569844.2	MdlB	106..687	CDD:224055	176/628 (28%)
		ABC_membrane	127..395	CDD:279056	65/293 (22%)
		ABC_MTABC3_MDL1_MDL2	447..686	CDD:213216	97/238 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458102
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24221
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940