Protein Alignment ABCB7 and pgp-8

DIOPT Version :9

• Sequence 1: NP_728642.2
• Gene: ABCB7 / 38193
• FlyBaseID: FBgn0035244
• Length: 743
• Species: Drosophila melanogaster
• Sequence 2: NP_509811.2
• Gene: pgp-8 / 181277
• WormBaseID: WBGene00004002
• Length: 1243
• Species: Caenorhabditis elegans
• Alignment Length: 561
• Identity: 173/561 - (30%)
• Similarity: 287/561 - (51%)
• Gaps: 62/561 - (11%)

  Fly   205 LMLGYGIARASAAGFNELRNAVFAKVAHHSIRKIASNVFLHLHNLDLAFHLNKQTGALSKTIDRG 269
            :::.:|:...:...|..::.::|..:..::..::.....|.|...|..:.....||.||..::..
 Worm    99 VVIHFGLVGCAFMFFGFIQFSLFKYIGDNTTYRLRHKFILRLLKKDAKYFDTISTGYLSTVLNDN 163

  Fly   270 --------SRGINFVL---------SAMVFNIVPTIFELALVSSILGVKCGLAFAGVSMGCVGIY 317
                    :..|.|::         :|:.|.   |.:.||...|:      .||..|..|.:.
 Worm   164 LERFREAFNEKIAFIICFSTDFAIGTALAFY---TSWTLASYGSV------FAFGIVISGLLN-- 217

  Fly   318 AAYTLSVTQWRTQFRVFMNQAENEAGNKAVDSLINYETVKYFNNEKYEAGCYNEVLKKYEAASLK 382
                 |.:..::..:..|:.  :.||..|..:|.:::||...|.:..|...|:..||:.|....:
 Worm   218 -----STSMMKSNEKQSMHY--SNAGAIAFQALCSFKTVISLNGQTQELEKYSAELKEGEKFGSR 275

  Fly   383 TSSSLALLNFGQNAIFSSALS-LIMVLAAKEIAQGNM-TVGDLVMVNALLFQ-LSIPLGFLGSVY 444
            .:..|| .:.|.:..|.:||: .|:.:.|..|....| ||..:.:.:.:||. .|:...||...|
 Worm   276 RAFFLA-TSRGLSHFFCNALNGTILYVGADLIYNKTMNTVAIVTLFHYMLFSAFSLGEAFLHISY 339

  Fly   445 REVRQALLDMRAMFTLMNVDSSI--------QTAANAQPLFVDTTNSSIEFRNVSFEYEPGKP-- 499
              :..|:.....:|.::..|..:        ||.:|      .|....:.|.||.|.| |.:|
 Worm   340 --LLNAINSATPIFDVLTSDDDMIENNQDNEQTDSN------KTIQGMLSFNNVKFAY-PSRPDV 395

  Fly   500 -IFRDLSFTIPAGKNVAIVGGSGSGKSSMVRLLFRFFEPNSGKVLIGGQDISAVDLESLRKVIAV 563
             |.|.:||.:..|:.:|:||.||||||::|:||..|:...||.:.||...:..::|:.||..|.|
 Worm   396 DILRGISFDVKQGECIALVGASGSGKSTIVQLLLHFYNIQSGTIKIGDSHLHDINLKQLRNAIGV 460

  Fly   564 VPQDSVLFHNTIEHNIHYGNLSKSHAEVQNAARMADLHDSIMSWPGQYSTQVGERGLKLSGGEKQ 628
            |.|:.|||:.|||.||.:||.:.:.:|:..|.|.|:.:|.:.:......|.|||||.:||||:||
 Worm   461 VSQEPVLFNTTIEENIRFGNPNATSSEIYEALRKANAYDFVCNIKDGLKTIVGERGAQLSGGQKQ 525

  Fly   629 RVAIARAILKNTPILIFDEATSSLDSITEHNILQALTRATSGRTSICIAHRLSTVKDADEILVLE 693
            |:||||.::||..||:.|||||:|||.:|..:..||.:|:.|||:|.|||||||::..|:|:|:.
 Worm   526 RIAIARVLVKNPAILLLDEATSALDSASERAVQLALKKASEGRTTIIIAHRLSTIRHCDKIMVMS 590

  Fly   694 NGRVGERGTHSELLRQNGLYARLWETQTQQFDPSREINEEV 734
            ||::.|.|:|.||:..:..|:.|  .:.|.|| |:.:.|::
 Worm   591 NGKIAEVGSHEELISMDREYSNL--VRAQFFD-SQSVEEDI 628

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCB7	NP_728642.2	ABC_membrane	164..437	CDD:294371	51/251 (20%)
		ATM1	222..717	CDD:227590	165/525 (31%)
		P-loop_NTPase	485..720	CDD:304359	107/237 (45%)
pgp-8	NP_509811.2	PTZ00265	29..1241	CDD:240339	173/561 (31%)
		ABC_membrane	44..326	CDD:294371	49/245 (20%)
		ABC_MTABC3_MDL1_MDL2	382..617	CDD:213216	107/237 (45%)
		ABC_membrane	685..953	CDD:279056
		ABC_MTABC3_MDL1_MDL2	1005..1240	CDD:213216

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248727at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920