Protein Alignment ABCB7 and hmt-1

DIOPT Version :10

• Sequence 1: NP_728642.2
• Gene: ABCB7 / 38193
• FlyBaseID: FBgn0035244
• Length: 743
• Species: Drosophila melanogaster
• Sequence 2: NP_001022812.1
• Gene: hmt-1 / 176540
• WormBaseID: WBGene00001815
• Length: 801
• Species: Caenorhabditis elegans
• Alignment Length: 629
• Identity: 251/629 - (39%)
• Similarity: 364/629 - (57%)
• Gaps: 26/629 - (4%)

  Fly   114 HIGGGSDGGSGLGKLDAPEVTSKDMLRAMMAYIWPKEDPLVRKRVGISLGLLAGSKLLTVCVPFL 178
            :..|.|...|....|....||       :..||||.:...::.||...|.||...:|:.|.:|.|
 Worm   190 NFSGCSSRESAWNNLSKKVVT-------VAPYIWPTKSISLQLRVVFCLFLLIIGRLINVSLPIL 247

  Fly   179 FKGAVDTMTTLNMDTAPDAVLSAATALMLGYGIARASAAGF-NELRNAVFAKVAHHSIRKIASNV 242
            .|..||.:.|  .||...::|..||.|....|  ..:..|| |.:|..::..:..::.|::...:
 Worm   248 SKWIVDELAT--PDTFQYSLLFLATFLKFLQG--NGAMGGFLNTVRTYLWIPIQQYTTRELEVEL 308

  Fly   243 FLHLHNLDLAFHLNKQTGALSKTIDRGSRGINFVLSAMVFNIVPTIFELALVSSILGVKCGLAFA 307
            |.|||:|.|.:||:::||.:.:.:|||:..:|.:|:.::||:||||.::.:............|.
 Worm   309 FKHLHSLSLRWHLSRKTGQVLRVMDRGTSSVNNILNYILFNVVPTIADIVIAVIFFFSAFNAYFG 373

  Fly   308 GVSMGCVGIYAAYTLSVTQWRTQFRVFMNQAENEAGNKAVDSLINYETVKYFNNEKYEAGCYNEV 372
            .:..|.:.:|...|:|:|:||||:....|:.:|.....|.|||||||||||:.||::|...:...
 Worm   374 LIVFGTMALYLTVTISITEWRTQYIREANEKDNATSAIATDSLINYETVKYYGNEEFEVNRFKNA 438

  Fly   373 LKKYEAASLKTSSSLALLNFGQNAIF------SSALSLIMVLAAKEIAQGNMTVGDLVMVNALLF 431
            ::.|:....||.:|||.||..||||.      .|...:.|::..|     .:||||.|:....|.
 Worm   439 IESYQVTEWKTQASLAFLNCLQNAIIGIGMIGGSVFVVYMIVHEK-----TLTVGDYVLFTTYLL 498

  Fly   432 QLSIPLGFLGSVYREVRQALLDMRAMFTLMNVDSSIQTAANAQPLFVDTTNSSIEFRNVSFEYEP 496
            ||..||.|.|::||.:::|.:||..||.|||.:..::...:|.| :.| ...:|..:|::|||..
 Worm   499 QLYTPLNFFGTIYRVIQKAFVDMENMFDLMNDEVEVKDLPHALP-YTD-PRGTISVKNLTFEYNT 561

  Fly   497 GKPIFRDLSFTIPAGKNVAIVGGSGSGKSSMVRLLFRFFEPNSGKVLIGGQDISAVDLESLRKVI 561
            |.|:.:::||.|..|:.||:||.||||||:::|||||.||...|.:...|.|:....:.|||:.|
 Worm   562 GLPVIKNISFEIGNGQTVALVGSSGSGKSTLIRLLFRLFESTEGSIEFDGIDVRNYTMHSLRQQI 626

  Fly   562 AVVPQDSVLFHNTIEHNIHYGNLSKSHAEVQNAARMADLHDSIMSWPGQYSTQVGERGLKLSGGE 626
            .:||||:|||::||.:||.:|....|..||..||:.|.:|:.|.|.|..|:|.||||||||||||
 Worm   627 GIVPQDTVLFNDTIMYNIRFGRPDASDEEVIEAAKAAMIHEKITSLPEGYATMVGERGLKLSGGE 691

  Fly   627 KQRVAIARAILKNTPILIFDEATSSLDSITEHNILQALTRATSGRTSICIAHRLSTVKDADEILV 691
            ||||||||.|||....:..|||||:||:.||..|.:.|.:....||.:.:|||||||.:||.|||
 Worm   692 KQRVAIARTILKKPQFIFLDEATSALDTPTERAIQKCLEKLCKSRTGVVVAHRLSTVVNADLILV 756

  Fly   692 LENGRVGERGTHSELLRQNGLYARLWETQ-TQQFDPSREINEEV 734
            |:.|.:.|||.|.|||.|.|.||.:||.| .:|...|.|:.||:
 Worm   757 LDKGIILERGNHKELLAQQGTYASMWEAQIAEQRAKSIELGEEL 800

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCB7	NP_728642.2	ATM1	147..732	CDD:444078	241/592 (41%)
hmt-1	NP_001022812.1	ATM1	213..791	CDD:444078	241/588 (41%)