DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABCB7 and Abcb6

DIOPT Version :9

Sequence 1:	NP_728642.2	Gene:	ABCB7 / 38193	FlyBaseID:	FBgn0035244	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_542149.1	Gene:	Abcb6 / 140669	RGDID:	71077	Length:	836	Species:	Rattus norvegicus

Alignment Length:	633	Identity:	254/633 - (40%)
Similarity:	380/633 - (60%)	Gaps:	27/633 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 RPQQQQSRLCHVHIGGGSDGGSGLGKLDAPEVTSKDM---LRAMMAYIWPKEDPLVRKRVGISLG 163
            ||   ||...||: ....|||...|:...|..|.:|:   ||.:..|:||:..|.::..|.:.:|
  Rat   210 RP---QSYTLHVN-EEDQDGGRNQGRSTDPRSTWRDLGRKLRLLSGYLWPRGSPSLQLTVLLCMG 270

  Fly   164 LLAGSKLLTVCVPFLFKGAVDTMTTLNMDTAPDAVL--SAATALMLGY--GIARASAAGFNELRN 224
            |:...:.|.|.||..::..|:.:|:    .||.:.|  :..|.:.|.:  |....|....:.||.
  Rat   271 LMGLDRALNVLVPIFYRDIVNLLTS----KAPWSSLAWTVTTYVFLKFLQGGGTGSTGFVSNLRT 331

  Fly   225 AVFAKVAHHSIRKIASNVFLHLHNLDLAFHLNKQTGALSKTIDRGSRGINFVLSAMVFNIVPTIF 289
            .::.:|...:.|.:...:|.|||.|.|.:||.::||.:.:.:|||:..:..:||.:||||:||:.
  Rat   332 FLWIRVQQFTSRGVELRLFSHLHELSLRWHLGRRTGEVLRIVDRGTSSVTGLLSYLVFNIIPTLA 396

  Fly   290 ELALVSSILGVKCGLAFAGVSMG-----CVGIYAAYTLSVTQWRTQFRVFMNQAENEAGNKAVDS 349
            ::     |:|:.....|.....|     |:.:|...|:.||:||.:||..||..||....:||||
  Rat   397 DI-----IIGIIYFSMFFNAWFGLIVFLCMSLYLILTIMVTEWRAKFRRDMNTQENATRARAVDS 456

  Fly   350 LINYETVKYFNNEKYEAGCYNEVLKKYEAASLKTSSSLALLNFGQNAIFSSALSLIMVLAAKEIA 414
            |:|:|||||:|.|.||...|.|.:.|::....|:::||.|||..||.:....|....:|.|..::
  Rat   457 LLNFETVKYYNAEGYELERYREAILKFQGLEWKSTASLVLLNQTQNMVIGFGLLAGSLLCAYFVS 521

  Fly   415 QGNMTVGDLVMVNALLFQLSIPLGFLGSVYREVRQALLDMRAMFTLMNVDSSIQTAANAQPLFVD 479
            :..:.|||.|:....:.||.:||.:.|:.||.::...:||..||.|:..::.::....|.||...
  Rat   522 ERRLQVGDFVLFGTYITQLYMPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDVPGAGPLRFH 586

  Fly   480 TTNSSIEFRNVSFEYEPGKPIFRDLSFTIPAGKNVAIVGGSGSGKSSMVRLLFRFFEPNSGKVLI 544
              ...:||.||.|.|..|:...:|:|||:..|:.||:||.||:|||:::||||||::.:||.:.|
  Rat   587 --KGRVEFENVHFSYADGRETLQDVSFTVMPGQTVALVGPSGAGKSTILRLLFRFYDISSGCIRI 649

  Fly   545 GGQDISAVDLESLRKVIAVVPQDSVLFHNTIEHNIHYGNLSKSHAEVQNAARMADLHDSIMSWPG 609
            .|||||.|...|||..|.|||||:|||::||.:||.||.::...:|:|.||:.|.:||:|:|:|.
  Rat   650 DGQDISQVTQISLRSHIGVVPQDTVLFNDTIANNIRYGRVTAGDSEIQAAAQAAGIHDAILSFPE 714

  Fly   610 QYSTQVGERGLKLSGGEKQRVAIARAILKNTPILIFDEATSSLDSITEHNILQALTRATSGRTSI 674
            .|.||||||||||||||||||||||.|||...|::.|||||:||:..|..|..:|.:..:.||:|
  Rat   715 GYETQVGERGLKLSGGEKQRVAIARTILKAPDIILLDEATSALDTSNERAIQASLAKVCTNRTTI 779

  Fly   675 CIAHRLSTVKDADEILVLENGRVGERGTHSELLRQNGLYARLWETQTQ 722
            .:|||||||.:||:|||:::|.:.|||.|..||.:.|:||.:|:.|.|
  Rat   780 VVAHRLSTVVNADQILVIKDGCIIERGRHEALLSRGGVYAEMWQLQQQ 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABCB7	NP_728642.2	ABC_membrane	164..437	CDD:294371	91/281 (32%)
		ATM1	222..717	CDD:227590	216/499 (43%)
		P-loop_NTPase	485..720	CDD:304359	127/234 (54%)
Abcb6	NP_542149.1	Required for ATPase activity. /evidence=ECO:0000250\|UniProtKB:Q9NP58	1..236		10/29 (34%)
		Required for the lysosomal targeting. /evidence=ECO:0000250\|UniProtKB:Q9NP58	1..205
		MTABC_N	6..255	CDD:292803	16/48 (33%)
		ABC_membrane	277..544	CDD:294371	90/275 (33%)
		ATM1	329..823	CDD:227590	216/500 (43%)
		ABCC_ATM1_transporter	590..825	CDD:213220	127/234 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5265
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248727at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820