DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ABCB7 and ABCB6

DIOPT Version :9

Sequence 1:	NP_728642.2	Gene:	ABCB7 / 38193	FlyBaseID:	FBgn0035244	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_005680.1	Gene:	ABCB6 / 10058	HGNCID:	47	Length:	842	Species:	Homo sapiens

Alignment Length:	615	Identity:	249/615 - (40%)
Similarity:	372/615 - (60%)	Gaps:	29/615 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 APEVTSKDM---LRAMMAYIWPKEDPLVRKRVGISLGLLAGSKLLTVCVPFLFKGAVDTMTTLNM 191
            |.:.|.:|.   ||.:..|:||:..|.::..|.|.|||:...:.|.|.||..::..|:.:|
Human   234 AQQSTWRDFGRKLRLLSGYLWPRGSPALQLVVLICLGLMGLERALNVLVPIFYRNIVNLLT---- 294

  Fly   192 DTAP-DAVLSAATA-----LMLGYGIARASAAGF-NELRNAVFAKVAHHSIRKIASNVFLHLHNL 249
            :.|| :::....|:     .:.|.|   ..:.|| :.||..::.:|...:.|::...:|.|||.|
Human   295 EKAPWNSLAWTVTSYVFLKFLQGGG---TGSTGFVSNLRTFLWIRVQQFTSRRVELLIFSHLHEL 356

  Fly   250 DLAFHLNKQTGALSKTIDRGSRGINFVLSAMVFNIVPTIFELALVSSILGVKCGLAFAGVSMG-- 312
            .|.:||.::||.:.:..|||:..:..:||.:|||::||:.::     |:|:.....|.....|
Human   357 SLRWHLGRRTGEVLRIADRGTSSVTGLLSYLVFNVIPTLADI-----IIGIIYFSMFFNAWFGLI 416

  Fly   313 ---CVGIYAAYTLSVTQWRTQFRVFMNQAENEAGNKAVDSLINYETVKYFNNEKYEAGCYNEVLK 374
               |:.:|...|:.||:|||:||..||..||....:|||||:|:|||||:|.|.||...|.|.:.
Human   417 VFLCMSLYLTLTIVVTEWRTKFRRAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREAII 481

  Fly   375 KYEAASLKTSSSLALLNFGQNAIFSSALSLIMVLAAKEIAQGNMTVGDLVMVNALLFQLSIPLGF 439
            ||:....|:|:||.|||..||.:....|....:|.|..:.:..:.|||.|:....:.||.:||.:
Human   482 KYQGLEWKSSASLVLLNQTQNLVIGLGLLAGSLLCAYFVTEQKLQVGDYVLFGTYIIQLYMPLNW 546

  Fly   440 LGSVYREVRQALLDMRAMFTLMNVDSSIQTAANAQPLFVDTTNSSIEFRNVSFEYEPGKPIFRDL 504
            .|:.||.::...:||..||.|:..::.::....|.||...  ...|||.||.|.|..|:...:|:
Human   547 FGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPLRFQ--KGRIEFENVHFSYADGRETLQDV 609

  Fly   505 SFTIPAGKNVAIVGGSGSGKSSMVRLLFRFFEPNSGKVLIGGQDISAVDLESLRKVIAVVPQDSV 569
            |||:..|:.:|:||.||:|||:::||||||::.:||.:.|.|||||.|...|||..|.|||||:|
Human   610 SFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQASLRSHIGVVPQDTV 674

  Fly   570 LFHNTIEHNIHYGNLSKSHAEVQNAARMADLHDSIMSWPGQYSTQVGERGLKLSGGEKQRVAIAR 634
            ||::||..||.||.::..:.||:.||:.|.:||:||::|..|.||||||||||||||||||||||
Human   675 LFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIAR 739

  Fly   635 AILKNTPILIFDEATSSLDSITEHNILQALTRATSGRTSICIAHRLSTVKDADEILVLENGRVGE 699
            .|||...|::.|||||:||:..|..|..:|.:..:.||:|.:|||||||.:||:|||:::|.:.|
Human   740 TILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVE 804

  Fly   700 RGTHSELLRQNGLYARLWETQTQQFDPSRE 729
            ||.|..||.:.|:||.:|:.|..|.:.|.:
Human   805 RGRHEALLSRGGVYADMWQLQQGQEETSED 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ABCB7	NP_728642.2	ABC_membrane	164..437	CDD:294371	93/284 (33%)
		ATM1	222..717	CDD:227590	218/499 (44%)
		P-loop_NTPase	485..720	CDD:304359	127/234 (54%)
ABCB6	NP_005680.1	Required for ATPase activity. /evidence=ECO:0000269\|PubMed:33007128	1..236		1/1 (100%)
		Required for the lysosomal targeting. /evidence=ECO:0000269\|PubMed:25627919	1..205
		MTABC_N	6..255	CDD:406569	6/20 (30%)
		ATM1	329..823	CDD:227590	218/500 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5265
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248727at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820