DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Taok2 and Pak

DIOPT Version :9

Sequence 1:	NP_001157247.1	Gene:	Taok2 / 381921	MGIID:	1915919	Length:	1240	Species:	Mus musculus
Sequence 2:	NP_001138013.2	Gene:	Pak / 44039	FlyBaseID:	FBgn0267698	Length:	840	Species:	Drosophila melanogaster

Alignment Length:	311	Identity:	120/311 - (38%)
Similarity:	173/311 - (55%)	Gaps:	20/311 - (6%)

- Green bases have known domain annotations that are detailed below.

Mouse     3 AGGRAGSLKDPDVAE----LFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSG 63
            |..:...:.|.::.|    :....||.:.::.:.:||.|:.|.||.|.:......||||:|:.|.
  Fly   537 ANAKKKKMSDEEILEKLRTIVSVGDPNRKYTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQ 601

Mouse    64 KQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCL-GSASDLLEVHKKPLQEVE 127
            :...|.   ||.|:..:::.:|||.:.|...||.....|:||||.. ||.:|:  |.:..:.|.:
  Fly   602 QPKKEL---IINEILVMRENKHPNVVNYLDSYLVSEELWVVMEYLPGGSLTDV--VTETCMDEGQ 661

Mouse   128 IAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPANS----FVGTPYW 188
            ||||....||.|.:||::.:||||:|:.||||...|.|||.|||..:.::|..|    .||||||
  Fly   662 IAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYW 726

Mouse   189 MAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPAL-QSGHWSE 252
            |||||:   ...||..|||:|||||..||:.|.:||..|.|.:.|||.||.|..|.: :....|.
  Fly   727 MAPEVV---TRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSS 788

Mouse   253 YFRNFVDSCLQKIPQDRPTSEV-LLKHRFVLRERPPTVIMDLIQRTKDAVR 302
            .|::|:|.||: :..||..|.: ||||.|:...||...:..||...|:|.:
  Fly   789 AFQDFLDQCLE-VEVDRRASALDLLKHPFLKLARPLASLTPLIMAAKEATK 838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Taok2	NP_001157247.1	STKc_TAO2	12..319	CDD:270804	119/302 (39%)
		S_TKc	28..281	CDD:214567	108/259 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	320..463
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	899..946
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1212..1240
Pak	NP_001138013.2	PBD	83..137	CDD:279166
		STKc_PAK_I	558..818	CDD:270814	111/268 (41%)
		S_TKc	566..817	CDD:214567	108/259 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910