DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13926 and HIKESHI

DIOPT Version :9

Sequence 1:	NP_647633.1	Gene:	CG13926 / 38192	FlyBaseID:	FBgn0035243	Length:	197	Species:	Drosophila melanogaster
Sequence 2:	NP_057485.2	Gene:	HIKESHI / 51501	HGNCID:	26938	Length:	197	Species:	Homo sapiens

Alignment Length:	201	Identity:	95/201 - (47%)
Similarity:	129/201 - (64%)	Gaps:	12/201 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LFGLIVSGRLPQSDFVAVDATKLLVNVPDIESVNYLVVFLTGVSPLPVGTSAAIYFSWPDANAAP 67
            :||.:|:|||.|:....|...|.:.::||.||:|::|||:.|..|.|.|...::|||:||:|..|
Human     1 MFGCLVAGRLVQTAAQQVAEDKFVFDLPDYESINHVVVFMLGTIPFPEGMGGSVYFSYPDSNGMP 65

  Fly    68 TWQYLGHINNTKPSAIFKIAQLKKSHELEAQAHGMVFGSQEI---SHIAQIGVSLEPELTVAQQT 129
            .||.||.:.|.||||||||:.||..   |...|  .||:..|   ..:||||:|:|...::||||
Human    66 VWQLLGFVTNGKPSAIFKISGLKSG---EGSQH--PFGAMNIVRTPSVAQIGISVELLDSMAQQT 125

  Fly   130 P----AVSTANDNKQFGQRMLENFFNYASSFGVAARDIPPISSETFVPFSVVQNWYTNFQRRMEQ 190
            |    |||:.:...||.|:||:||:|:||||.|:...:.|..||.|:|.:||..||.|||||:.|
Human   126 PVGNAAVSSVDSFTQFTQKMLDNFYNFASSFAVSQAQMTPSPSEMFIPANVVLKWYENFQRRLAQ 190

  Fly   191 NPNFWK 196
            ||.|||
Human   191 NPLFWK 196

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13926	NP_647633.1	DUF775	3..192	CDD:283295	90/195 (46%)
HIKESHI	NP_057485.2	DUF775	1..195	CDD:398953	92/198 (46%)
		Required for F-X-F-G repeats-nucleoporins recognition and nuclear import. /evidence=ECO:0000269\|PubMed:22541429	18..55		14/36 (39%)
		Flexible linker region involved in nuclear import of HSP70 proteins. /evidence=ECO:0000269\|PubMed:22541429	124..134		5/9 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145375
Domainoid	1	1.000	178	1.000	Domainoid score	I3589
eggNOG	1	0.900	-	-		E1_KOG4067
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6908
Inparanoid	1	1.050	180	1.000	Inparanoid score	I4016
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55986
OrthoDB	1	1.010	-	-		D1223488at2759
OrthoFinder	1	1.000	-	-		FOG0005749
OrthoInspector	1	1.000	-	-		oto88754
orthoMCL	1	0.900	-	-		OOG6_102809
Panther	1	1.100	-	-	LDO	PTHR12925
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R869
SonicParanoid	1	1.000	-	-		X4730
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800