Protein Alignment CG12104 and TOX4

DIOPT Version :9

• Sequence 1: NP_001261267.1
• Gene: CG12104 / 38187
• FlyBaseID: FBgn0035238
• Length: 250
• Species: Drosophila melanogaster
• Sequence 2: NP_055643.1
• Gene: TOX4 / 9878
• HGNCID: 20161
• Length: 621
• Species: Homo sapiens
• Alignment Length: 591
• Identity: 115/591 - (19%)
• Similarity: 156/591 - (26%)
• Gaps: 347/591 - (58%)

  Fly     4 FHTPSFGDEVFE-----------------------LTDTPAESQSPSQASR-------------- 31
            |||||.|||.||                       |.| |:.||..|.:::
Human    27 FHTPSLGDEEFEIPPISLDSDPSLAVSDVVGHFDDLAD-PSSSQDGSFSAQYGVQTLDMPVGMTH 90

  Fly    32 -------------RMLSLDQSM------------------------------LNDDDEENCDTYA 53
                         ..:.||.|:                              ..|..|.:.....
Human    91 GLMEQGGGLLSGGLTMDLDHSIGTQYSANPPVTIDVPMTDMTSGLMGHSQLTTIDQSELSSQLGL 155

  Fly    54 SGGGQNLL---VQPEQQ-------------------------QNQAMAQA--------------- 75
            |.||..:|   ..||.:                         |...:.:|
Human   156 SLGGGTILPPAQSPEDRLSTTPSPTSSLHEDGVEDFRRQLPSQKTVVVEAGKKQKAPKKRKKKDP 220

  Fly    76 --PPKPLAPFALFFRDTVTAIKQQNPTCSLEQMQVIVQTMWESLDETQKNVYALRHEQEKREYVR 138
              |.||::.:|||||||..|||.|||..:..::..||.:||:||.|.||.||..:.|..|:||::
Human   221 NEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDSLGEEQKQVYKRKTEAAKKEYLK 285

  Fly   139 LMRGYRHQLSESEGTSEA----EAPPAVATNQPPPLVT--------------------------- 172
            .:..|:.. .|.:.|.|.    .|||: .|..|||:.|
Human   286 ALAAYKDN-QECQATVETVELDPAPPS-QTPSPPPMATVDPASPAPASIEPPALSPSIVVNSTLS 348

  Fly   173 -----------------TKL--------------------------------------------- 175
                             |||
Human   349 SYVANQASSGAGGQPNITKLIITKQMLPSSITMSQGGMVTVIPATVVTSRGLQLGQTSTATIQPS 413

  Fly   176 --------------------------------------------ESVEDLQQ------------- 183
                                                        :.|..|||
Human   414 QQAQIVTRSVLQAAAAAAAAASMQLPPPRLQPPPLQQMPQPPTQQQVTILQQPPPLQAMQQPPPQ 478

  Fly   184 --SVDAQQEPPPDQIQLL---------------------------TEAARVQ------------- 206
              .::.||:|||.||:.:                           .||..|:
Human   479 KVRINLQQQPPPLQIKSVPLPTLKMQTTLVPPTVESSPERPMNNSPEAHTVEAPSPETICEMITD 543

  Fly   207 ---------------------------KCTREQCNKPAIINPDWEDEYCSNECVVIHCRNVFNHW 244
                                       :|.|..|..|.|::.||::|||||||||.|||:||..|
Human   544 VVPEVESPSQMDVELVSGSPVALSPQPRCVRSGCENPPIVSKDWDNEYCSNECVVKHCRDVFLAW 608

  Fly   245 VISMNS 250
            |.|.||
Human   609 VASRNS 614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12104	NP_001261267.1	HMG-box	76..140	CDD:238037	31/63 (49%)
TOX4	NP_055643.1	NHP6B	140..>306	CDD:227935	45/166 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	153..227		10/73 (14%)
		Nuclear localization signal. /evidence=ECO:0000255	213..218		0/4 (0%)
		HMG-box	223..288	CDD:238037	31/64 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	305..333		8/28 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	510..529		2/18 (11%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	73	1.000	Domainoid score	I9245
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000742
OrthoInspector	1	1.000	-	-		otm40922
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4401
SonicParanoid	1	1.000	-	-		X923
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	6.030