DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG12104 and TOX

DIOPT Version :9

Sequence 1:NP_001261267.1 Gene:CG12104 / 38187 FlyBaseID:FBgn0035238 Length:250 Species:Drosophila melanogaster
Sequence 2:NP_055544.1 Gene:TOX / 9760 HGNCID:18988 Length:526 Species:Homo sapiens


Alignment Length:324 Identity:76/324 - (23%)
Similarity:119/324 - (36%) Gaps:117/324 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 TDTPAESQSPSQASRRMLSLDQSMLNDDDEENCDTYASGGGQ-----NLLVQPE--QQQNQAMAQ 74
            ::.|..|.||..:.....|...|:..|:.:   ||....||:     ::..:|:  :::.:....
Human   198 SNVPHNSPSPPGSKSATPSPSSSVHEDEGD---DTSKINGGEKRPASDMGKKPKTPKKKKKKDPN 259

  Fly    75 APPKPLAPFALFFRDTVTAIKQQNPTCSLEQMQVIVQTMWESLDETQKNVYALRHEQEKREYVRL 139
            .|.||::.:|||||||..|||.|||..:..::..||.:||:.|.|.||.||..:.|..|:||::.
Human   260 EPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDGLGEEQKQVYKKKTEAAKKEYLKQ 324

  Fly   140 MRGYRHQLSESEGTSEAEAPPAVATNQPPPLVTTK------------------------------ 174
            :..||..| .|:..||   |..|.|:|||.|:.:|                              
Human   325 LAAYRASL-VSKSYSE---PVDVKTSQPPQLINSKPSVFHGPSQAHSALYLSSHYHQQPGMNPHL 385

  Fly   175 -----------------------------------LESVEDLQQSVDAQQEPP-----------P 193
                                               |:....|.|.::.||..|           |
Human   386 TAMHPSLPRNIAPKPNNQMPVTVSIANMAVSPPPPLQISPPLHQHLNMQQHQPLTMQQPLGNQLP 450

  Fly   194 DQIQLLTEAARVQKCTREQCNKPAIINP---------------------------DWEDEYCSN 230
            .|:|....:..:|:....|.:...||||                           ||.::|||:
Human   451 MQVQSALHSPTMQQGFTLQPDYQTIINPTSTAAQVVTQAMEYVRSGCRNPPPQPVDWNNDYCSS 514

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG12104NP_001261267.1 HMG-box 76..140 CDD:238037 30/63 (48%)
TOXNP_055544.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 138..178
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 192..264 13/68 (19%)
Nuclear localization signal. /evidence=ECO:0000255 237..256 1/18 (6%)
NHP6B <257..>360 CDD:227935 44/106 (42%)
HMG-box 261..>310 CDD:238037 24/48 (50%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 73 1.000 Domainoid score I9245
eggNOG 1 0.900 - - E1_COG5648
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000742
OrthoInspector 1 1.000 - - otm40922
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X923
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
76.770

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