DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12104 and Hmgb2

DIOPT Version :9

Sequence 1:	NP_001261267.1	Gene:	CG12104 / 38187	FlyBaseID:	FBgn0035238	Length:	250	Species:	Drosophila melanogaster
Sequence 2:	NP_001350372.1	Gene:	Hmgb2 / 97165	MGIID:	96157	Length:	210	Species:	Mus musculus

Alignment Length:	123	Identity:	28/123 - (22%)
Similarity:	51/123 - (41%)	Gaps:	14/123 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 APPKPLAPFALFFRDTVTAIKQQNPTCSLEQMQVIVQTMWESLDETQKNVYALRHEQEKREYVRL 139
            ||.:|.:.|.||..:....||.::|..|:......:..||.......|..|..:..:.|.:|.:.
Mouse    94 APKRPPSAFFLFCSENRPKIKIEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKD 158

  Fly   140 MRGYRHQLSESEGTSEA--EAPPAVATNQPPPLVTTKLESVEDLQQSVDAQQEPPPDQ 195
            :..||     ::|.|||  :.|..       |..:.|....||.::..:.::|...::
Mouse   159 IAAYR-----AKGKSEAGKKGPGR-------PTGSKKKNEPEDEEEEEEEEEEEDDEE 204

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12104	NP_001261267.1	HMG-box	76..140	CDD:238037	15/63 (24%)
Hmgb2	NP_001350372.1	HMG-box	7..78	CDD:320749
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	71..102		3/7 (43%)
		HMG_box	95..162	CDD:278906	15/66 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..210		12/55 (22%)
		Required for chemotactic activity. /evidence=ECO:0000250\|UniProtKB:P26583	165..180		6/21 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5648
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900