DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12104 and HMGB2

DIOPT Version :9

Sequence 1:	NP_001261267.1	Gene:	CG12104 / 38187	FlyBaseID:	FBgn0035238	Length:	250	Species:	Drosophila melanogaster
Sequence 2:	NP_001124160.1	Gene:	HMGB2 / 3148	HGNCID:	5000	Length:	209	Species:	Homo sapiens

Alignment Length:	127	Identity:	30/127 - (23%)
Similarity:	53/127 - (41%)	Gaps:	17/127 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 APPKPLAPFALFFRDTVTAIKQQNPTCSLEQMQVIVQTMWESLDETQKNVYALRHEQEKREYVRL 139
            ||.:|.:.|.||..:....||.::|..|:......:..||.......|..|..:..:.|.:|.:.
Human    94 APKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKD 158

  Fly   140 MRGYRHQLSESEGTSEA-EAPPAVAT-----NQPPPLVTTKLESVEDLQQSVDAQQEPPPDQ 195
            :..||     ::|.||| :..|...|     |:|..      |..|:.::..|.::|...::
Human   159 IAAYR-----AKGKSEAGKKGPGRPTGSKKKNEPED------EEEEEEEEDEDEEEEDEDEE 209

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12104	NP_001261267.1	HMG-box	76..140	CDD:238037	15/63 (24%)
HMGB2	NP_001124160.1	HMG_box_2	6..78	CDD:401091
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	52..150		14/55 (25%)
		HMG_box	95..162	CDD:395407	15/66 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..209		14/57 (25%)
		Required for chemotactic activity. /evidence=ECO:0000269\|PubMed:19811285	165..180		5/14 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5648
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900