DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12104 and TOX3

DIOPT Version :9

Sequence 1:	NP_001261267.1	Gene:	CG12104 / 38187	FlyBaseID:	FBgn0035238	Length:	250	Species:	Drosophila melanogaster
Sequence 2:	NP_001073899.2	Gene:	TOX3 / 27324	HGNCID:	11972	Length:	576	Species:	Homo sapiens

Alignment Length:	204	Identity:	61/204 - (29%)
Similarity:	93/204 - (45%)	Gaps:	32/204 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 PAESQSPSQASRRMLSLDQSMLNDDDEENCD------TYASGGGQNLLVQPE--QQQNQAMAQAP 76
            |..|.|| .||:.......|.:|::|.:..:      ..|...|:    :|:  :::.:.....|
Human   196 PHTSPSP-PASKSATPSPSSSINEEDADEANRAIGEKRAAPDSGK----KPKTPKKKKKKDPNEP 255

  Fly    77 PKPLAPFALFFRDTVTAIKQQNPTCSLEQMQVIVQTMWESLDETQKNVYALRHEQEKREYVRLMR 141
            .||::.:|||||||..|||.|||..:..::..||.:||:||.|.||.||..:.|..|:||::.:.
Human   256 QKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDSLGEEQKQVYKRKTEAAKKEYLKALA 320

  Fly   142 GYRHQLSESEGTSEAEAPPAVATNQPPPLVTTKL-----------------ESVEDLQQSVDAQQ 189
            .||..|........|||....:..|  .|.:|.|                 .|.:.||||:....
Human   321 AYRASLVSKAAAESAEAQTIRSVQQ--TLASTNLTSSLLLNTPLSQHGTVSASPQTLQQSLPRSI 383

  Fly   190 EPPPDQIQL 198
            .|.|..::|
Human   384 APKPLTMRL 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12104	NP_001261267.1	HMG-box	76..140	CDD:238037	31/63 (49%)
TOX3	NP_001073899.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	189..258		13/66 (20%)
		HMG-box	255..320	CDD:238037	31/64 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	422..443
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	519..563
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	73	1.000	Domainoid score	I9245
eggNOG	1	0.900	-	-		E1_COG5648
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000742
OrthoInspector	1	1.000	-	-		otm40922
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X923
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.860