DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13917 and KLHL24

DIOPT Version :9

Sequence 1:	NP_001189017.1	Gene:	CG13917 / 38186	FlyBaseID:	FBgn0035237	Length:	2019	Species:	Drosophila melanogaster
Sequence 2:	NP_001336342.1	Gene:	KLHL24 / 54800	HGNCID:	25947	Length:	625	Species:	Homo sapiens

Alignment Length:	324	Identity:	64/324 - (19%)
Similarity:	128/324 - (39%)	Gaps:	74/324 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  1073 VQGQQVDYIQTDLSADSSLASSFSRSGMDESSLSCRQ------PRRLGEDLLKMFLQ----EIAT 1127
            :.|::::  :.||....|.|:......||..||:..:      .....|::|::|.:    .:.|
Human     4 ILGRRLN--REDLGVRDSPATKRKVFEMDPKSLTGHEFFDFSSGSSHAENILQIFNEFRDSRLFT 66

  Fly  1128 DMLVEVHGRRIRAHKCILRSRCQYFAAMLAGHGSQS---VVSLQGYSYAAVHFALCHIYSG---- 1185
            |:::.|.|:....|:.:|.:...||.||......:|   :|.:.|....|:...|.::|:|
Human    67 DVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLVEINGILAEAMECFLQYVYTGKVKI 131

  Fly  1186 ----ASHPPDGISLMELAALADLLGLEGLKEVTAHALKTNYCHNFHK----PCSGCSDGILQVLP 1242
                ..:..:..||.:::.|.|.                  |..|.:    ||: |    |.:..
Human   132 TTENVQYLFETSSLFQISVLRDA------------------CAKFLEEQLDPCN-C----LGIQR 173

  Fly  1243 VALNHALDDLYRKCLRWTCRHYLKVWPTRQFAQLPPDILGRCRQQIVAYMTSDTVLDTVLDCDHL 1307
            .|..|:|..|:.||..:..:.:..|....:|.:|..|       :::.|:.||   :.|:..:.:
Human   174 FADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKD-------ELIDYICSD---ELVIGKEEM 228

  Fly  1308 LAQLSAYRWGHVCEQLVREILEAAYAYV------GDHFASLIASDSFL-------SLGHDRSRH 1358
            :.: :..||.:....|.|.:|.....:|      .::|...:..|..:       .|.|:..|:
Human   229 VFE-AVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHEARRY 291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13917	NP_001189017.1	BTB	1117..>1185	CDD:279045	18/74 (24%)
		BTB	1128..>1191	CDD:197585	16/73 (22%)
		BACK	1238..>1281	CDD:197943	11/42 (26%)
KLHL24	NP_001336342.1	BTB	62..591	CDD:333434	52/264 (20%)
		KELCH repeat	354..393	CDD:276965
		KELCH repeat	397..466	CDD:276965
		KELCH repeat	469..514	CDD:276965
		KELCH repeat	517..556	CDD:276965
		KELCH repeat	559..604	CDD:276965
		Kelch	570..616	CDD:128874
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910