DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13917 and klhl21

DIOPT Version :9

Sequence 1:	NP_001189017.1	Gene:	CG13917 / 38186	FlyBaseID:	FBgn0035237	Length:	2019	Species:	Drosophila melanogaster
Sequence 2:	NP_001307336.1	Gene:	klhl21 / 404613	ZFINID:	ZDB-GENE-040426-2627	Length:	613	Species:	Danio rerio

Alignment Length:	329	Identity:	64/329 - (19%)
Similarity:	107/329 - (32%)	Gaps:	117/329 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1128 DMLVEVHGRRIRAHKCILRSRCQYFAAMLAGHGSQSV---VSLQGYSYAAVHFALCHIYSG---A 1186
            |:.:...|:....|:.:|.:...||.||.||...:||   |.|...|...:...:...|:|   .
Zfish    39 DVTLCAEGKEFHCHRTVLAAASMYFRAMFAGTLRESVMDRVVLHEVSAELLGLLVDFCYTGRVTV 103

  Fly  1187 SHPPDGISLMELAALADLLGLEGLKEVTAHALKTNYCHNFHKPCSGCSDGILQVLPVALNHALDD 1251
            :|  |.:.|  |...|||.....:||.....|:...      ..|.|    |::...|..:|..:
Zfish   104 TH--DNVDL--LLKTADLFQFPSVKEACCAFLEQRL------DVSNC----LEIQDFAEAYACRE 154

  Fly  1252 L----------------------------------------------YRKCLRWT---CRHYLKV 1267
            |                                              |:..:||.   .:|.|..
Zfish   155 LAASARRFVLKNIVELAKSMDFERLSWKRLLEFVSDDGLCVDKEETAYQIAVRWVKADLQHRLHY 219

  Fly  1268 WP-TRQFAQLPPDILGRCRQQIVAYMTSDTVLDTVLDCDHLLAQLSAY---------RWGH---- 1318
            || ..|..:||   ..| |..::|::.||.::.....|..|:::..::         |.||
Zfish   220 WPELLQQVRLP---FVR-RFYLLAHVESDPLVYLSPACLRLVSEARSFQSYEYDRHDRPGHRMRP 280

  Fly  1319 ------------------VCEQLV------------REILEAAYAYVGDHFASLIASDSFLSLGH 1353
                              .|::||            |.:.|......|.:..:.:.:|.:::.|.
Zfish   281 RPSTGLAEILVVVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGGGYSIAALGNDIYVTGGS 345

  Fly  1354 DRSR 1357
            |.||
Zfish   346 DGSR 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13917	NP_001189017.1	BTB	1117..>1185	CDD:279045	16/59 (27%)
		BTB	1128..>1191	CDD:197585	18/68 (26%)
		BACK	1238..>1281	CDD:197943	14/92 (15%)
klhl21	NP_001307336.1	BTB	35..549	CDD:333434	64/329 (19%)
		Kelch 1	289..337		6/47 (13%)
		KELCH repeat	328..370	CDD:276965	6/22 (27%)
		Kelch 2	338..384		5/12 (42%)
		KELCH repeat	374..411	CDD:276965
		Kelch 3	386..424
		KELCH repeat	414..455	CDD:276965
		Kelch 4	426..472
		Kelch 5	474..514
		KELCH repeat	504..550	CDD:276965
		Kelch 6	515..562
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910