Protein Alignment CG13917 and BTBD8

DIOPT Version :9

• Sequence 1: NP_001189017.1
• Gene: CG13917 / 38186
• FlyBaseID: FBgn0035237
• Length: 2019
• Species: Drosophila melanogaster
• Sequence 2: NP_001363060.1
• Gene: BTBD8 / 284697
• HGNCID: 21019
• Length: 1792
• Species: Homo sapiens
• Alignment Length: 1124
• Identity: 257/1124 - (22%)
• Similarity: 467/1124 - (41%)
• Gaps: 209/1124 - (18%)

  Fly  1007 SSQLGQ---RLYRDENRA-----------RPHSWAMT--------RSTGNTLQNFTN----SVDN 1045
            |.||.|   ||.|:|...           :.|...:.        .:.|.|..:.||    :|:|
Human    41 SEQLSQDLLRLLREEFHTDVTFSVGCTLFKAHKAVLLARVPDFYFHTIGQTSNSLTNQEPIAVEN 105

  Fly  1046 IRSL------------SRLFPNFSKEF--SNSLPNGMTLEQVQGQQVDYIQTDLSADSSLAS--- 1093
            :.:|            :|...|:.:|.  ...:..|::.:|:   .:.:.:.:.|:|.||..
Human   106 VEALEFRTFLQIIYSSNRNIKNYEEEILRKKIMEIGISQKQL---DISFPKCENSSDCSLQKHEI 167

  Fly  1094 SFSRSGMDESSLS-----CRQPRRLGEDLLKMFLQEIATDMLVEVHGRRIRAHKCILRSRCQYFA 1153
            ....|..|:..:|     ......|||||||::::....|:.:.|.|:|.:||:.||.:|..|||
Human   168 PEDISDRDDDFISNDNYDLEPASELGEDLLKLYVKPCCPDIDIFVDGKRFKAHRAILSARSSYFA 232

  Fly  1154 AMLAG---HGSQSVVSLQGYSYAAVHFALCHIYSGASHPPDGISLMELAALADLLGLEGLKEVTA 1215
            |||:|   ..||..|:|||.|:..::..:..||.|....||..::.::..:||:.||||||||..
Human   233 AMLSGCWAESSQEYVTLQGISHVELNVMMHFIYGGTLDIPDKTNVGQILNMADMYGLEGLKEVAI 297

  Fly  1216 HALKTNYCHNFHKPCSGCSDGILQVLPVALNHALDDLYRKCLRWTCRHYLKVWPTRQFAQLPPDI 1280
            :.|:.:||:.|.||.......||:.|.:|.:..::.|:..|::|..:|:.:.|..|.||.:||:|
Human   298 YILRRDYCNFFQKPVPRTLTSILECLIIAHSVGVESLFADCMKWIVKHFARFWSERSFANIPPEI 362

  Fly  1281 LGRCRQQIVAYMTSDTVLDTVLDCDHLLAQLSAYRWGHVCEQLVREILEAAYAYVGDHFASLIAS 1345
            ...|...::..:........:::.|.|:..|...:|......:..::.|...|::.|:|:.:|.|
Human   363 QKSCLNMLIQSLNDKNAAFLLMESDRLIISLPRVKWTEAALTMASQLQEKCIAFIVDNFSKIIQS 427

  Fly  1346 DSFLSL--GHDRSRHIPRLETLLLHTAAELTPEQACRSYQRVTRLNTVLQAKVIHMPASLGQSEL 1408
            ::|..|  ....|.....|:|:|......:|.|.:|   ..:..|:|:|.:.      |..:...
Human   428 ENFALLLQSQAMSSTADLLDTILKAIEENITTENSC---SLLMALDTLLNSD------STKEMGF 483

  Fly  1409 ARELQGLQEEQLDWQPEYIRLVGALVYAVEQCLIRQCSRAMRVTAWQRMDLELRKKIQTLARLTE 1473
            ..::|.|:::.      :|.||.:. |||.           ...:|:.|..:.::|||..|  .:
Human   484 TCKIQALRDKL------WIFLVQSF-YAVR-----------HTESWKLMSTDDQQKIQAAA--FD 528

  Fly  1474 PLDMKRQNGKPVGKAFSFGGSTRSQDLVQIKLAIQAQTKRA-NAQETLMYKATQTQ---DAAGGA 1534
            ..|.:|...||:   ||   |::.:..|.....|:.::.|. |.:|...|.:|..:   |..|.:
Human   529 KGDDRRLGKKPI---FS---SSQQRKQVSDSGDIKIKSWRGNNKKECWSYLSTNKKMKSDGLGAS 587

  Fly  1535 GHVQTADRGVQANHESREGGSKLLKSNSRAYVPHRASSQVATERNSLNLHRRTQSEAPPVTHKKP 1599
            ||         ::..:|...:|.||.:.   |..:..:::|::     :.:..::....|: .||
Human   588 GH---------SSSTNRNSINKTLKQDD---VKEKDGTKIASK-----ITKELKTGGKNVS-GKP 634

  Fly  1600 ITVAASTVESKSAQGKPNAAAAKLGEVRPRYLEPRKPRAMAPSAT------NGHGA----GPVRS 1654
            .||..|..|        |...|:|..:.||.:..|...| |.:||      ||.|.    |.:..
Human   635 KTVTKSKTE--------NGDKARLENMSPRQVVERSATA-AAAATGQKNLLNGKGVRNQEGQISG 690

  Fly  1655 ATSSSIPANGGRKAPAKNLHISSSDSS---RNSSPAARRVQNGTRLGNKSSNLSMDSLASPARRA 1716
            |....:..|...:|.||.|..::...|   ..:.|::|...:....     ::|.:.|..|....
Human   691 ARPKVLTGNLNVQAKAKPLKKATGKDSPCLSIAGPSSRSTDSSMEF-----SISTECLDEPKENG 750

  Fly  1717 KSSSRGPQERYSSDQNSLAESMKSSV--ITNKTISHES------LSGSSKLARIQQ----ING-- 1767
            .:....|.....|..:|..:.||:||  :.|.|::.:|      .:|:|....|.:    :|.
Human   751 STEEEKPSGHKLSFCDSPGQMMKNSVDSVKNSTVAIKSRPVSRVTNGTSNKKSIHEQDTNVNNSV 815

  Fly  1768 ----HSKGA------ATGKIKATQRGSTVGNKSTRQLKQQ-HNAMASNGSSPSSVHTTKSAASRL 1821
                ..||.      |..|.:.|..|.|...:.|:..... .....|.|.||:||.::.|:....
Human   816 LKKVSGKGCSEPVPQAILKKRGTSNGCTAAQQRTKSTPSNLTKTQGSQGESPNSVKSSVSSRQSD 880

  Fly  1822 SSVS----STLSTRELFKQRSISVPAGGTDGAPNKGRHSFLSAKSREILAKRAEKNKLQQ----Q 1878
            .:|:    :|.:.::..|::.:            |..|:.|...:.:|:|.....|:.::    .
Human   881 ENVAKLDHNTTTEKQAPKRKMV------------KQVHTALPKVNAKIVAMPKNLNQSKKGETLN 933

  Fly  1879 QQQQKQTEAPVEERGSVQLRSSAGPLRSSSHSAVSSMLQQHNLR-NSLPSNIPTRRPN------T 1936
            .:..||...|.:.....| .||..||:..:.:...||.  |::| |:...::..::|:      .
Human   934 NKDSKQKMPPGQVISKTQ-PSSQRPLKHETSTVQKSMF--HDVRDNNNKDSVSEQKPHKPLINLA 995

  Fly  1937 LHLKKTTAATNGVGGGPTKTTTNGMSNGTYKSAQAVK----QKLDLLIDAQMES-VVPRERVESK 1996
            ..:....|..:.....|.|..     |...|...|::    .|||..:..::|| .:..::.|:|
Human   996 SEISDAEALQSSCRPDPQKPL-----NDQEKEKLALECQNISKLDKSLKHELESKQICLDKSETK 1055

  Fly  1997 LERSSTFCKDSADLDISEL 2015
            ....    |::.|.|.:.:
Human  1056 FPNH----KETDDCDAANI 1070

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG13917	NP_001189017.1	BTB	1117..>1185	CDD:279045	28/70 (40%)
		BTB	1128..>1191	CDD:197585	26/65 (40%)
		BACK	1238..>1281	CDD:197943	13/42 (31%)
BTBD8	NP_001363060.1	BTB1_POZ_BTBD8	43..147	CDD:349594	19/103 (18%)
		BTB2_POZ_BTBD8	189..309	CDD:349595	48/119 (40%)
		BACK_BTBD8	316..378	CDD:350565	16/61 (26%)
		BACK	396..>451	CDD:391941	12/54 (22%)
		DUF4596	1749..1792	CDD:373786

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I9199
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007444
OrthoInspector	1	1.000	-	-		oto89252
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5772
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.940