Protein Alignment CG13917 and IBTK

DIOPT Version :9

• Sequence 1: NP_001189017.1
• Gene: CG13917 / 38186
• FlyBaseID: FBgn0035237
• Length: 2019
• Species: Drosophila melanogaster
• Sequence 2: XP_006715516.1
• Gene: IBTK / 25998
• HGNCID: 17853
• Length: 1394
• Species: Homo sapiens
• Alignment Length: 1287
• Identity: 233/1287 - (18%)
• Similarity: 394/1287 - (30%)
• Gaps: 473/1287 - (36%)

  Fly   678 SSSLSSSASRRGDTEVMKSSASSTETLMAKSANLKDVSAGAGESKSLDYRCNLE-------PPLT 735
            |...:...:.|||..::  :....:.:.:|..|||.|....|.   ::|:.:.|       ..:.
Human   348 SDGATVCVTTRGDIYLL--ADYQCKKMASKQLNLKKVLVSGGH---MEYKVDPEHLKENGGQKIC 407

  Fly   736 VAALRRLSQQH--RQQSDPSKRHSWGSNGQPEQA-----------------SGSG---------- 771
            :.|:....:..  |..:...|:..|   ..|.|.                 .|.|
Human   408 ILAMDGAGRVFCWRSVNSSLKQCRW---AYPRQVFISDIALNRNEILFVTQDGEGFRGRWFEEKR 469

  Fly   772 TGNDCKRSISLTANGATDSG--AGLMSI-----IDKLPIISKASSLSIDSSVSPYDDFSGSN--- 826
            ..::.|..:|...|.::|..  :.:.|:     ::||....:|.|:|.|.        ||.|
Human   470 KSSEKKEILSNLHNSSSDVSYVSDINSVYERIRLEKLTFAHRAVSVSTDP--------SGCNFAI 526

  Fly   827 ------------PGISSCS-EEEQGQVQGRIKKRRRDVQINETYDKSSLASVTEGILSKDLSPA- 877
                        |.:||.| .||.|::            :.|..:..|:..||..:.:: |.||
Human   527 LQSDPKTSLYEIPAVSSSSFFEEFGKL------------LREADEMDSIHDVTFQVGNR-LFPAH 578

  Fly   878 ----------------SNTDTDDLT--FQQDEQLA--------KEQAELVSVPLQL--TSSSNRT 914
                            |:.:|.:.|  :|:||..|        |...::....||.  |.:.:..
Human   579 KYILAVHSDFFQKLFLSDGNTSEFTDIYQKDEDSAGCHLFVVEKVHPDMFEYLLQFIYTDTCDFL 643

  Fly   915 SSVMETIIEAKETASPKKQVTLSNGHTMESLHATIEKQKQLLETVNEHGEQT-TQQPSQIPSSFV 978
            :...:..|...:  :|::.....|.|..:......:.||...|....:..|| :::....|.|..
Human   644 THGFKPRIHLNK--NPEEYQGTLNSHLNKVNFHEDDNQKSAFEVYKSNQAQTVSERQKSKPKSCK 706

  Fly   979 KLSDMDKPVKHDLQSPDSMSKSVGNNHRSSQLGQRL--YRDENRARPHSWAMTRSTGNTLQNFTN 1041
            |    .|.::.|  .|..|.::|......|.|..||  .|.||....   .:.::|||.|:
Human   707 K----GKNIRED--DPVRMLQTVAKKFDFSNLSSRLDGVRFENEKIN---VIAKNTGNKLK---- 758

  Fly  1042 SVDNIRSLSRLFPNFSKEFSNSLPNGMTLEQVQGQQVDYIQTDLSADSSLASSFSRSGMDESSLS 1106
                   ||:      |:.|
Human   759 -------LSQ------KKCS--------------------------------------------- 765

  Fly  1107 CRQPRRLGEDLLKMFLQEIATDMLVEVHGRRIRAHKCILRSRCQYFAAMLAGHGSQSVVSLQGYS 1171
                          ||.::.   :..|.|:....|||:|.:|.:||.:||:...      ::..|
Human   766 --------------FLCDVT---MKSVDGKEFPCHKCVLCARLEYFHSMLSSSW------IEASS 807

  Fly  1172 YAA----VHFALCHIYSGASHPPDGISLME---------LAALADLLGLEGLKEVTAHALKTNYC 1223
            .||    :|..:..:.....:..:.:.:.|         :..:||.|.:..|||:...||....
Human   808 CAALEMPIHSDILKVILDYLYTDEAVVIKESQNVDFICSVLVVADQLLITRLKEICEVALTEKL- 871

  Fly  1224 HNFHKPCSGCSDGILQVLPVALNHALDDLYRKCLRWTCRHYLKVWPTRQFAQLPPDILGRCRQQI 1288
                     .......:|..|..::...|...||              ||..|....|...|.
Human   872 ---------TLKNAAMLLEFAAMYSAKQLKLSCL--------------QFIGLNMAALLEARS-- 911

  Fly  1289 VAYMTSDTVLDTVLDCDHLLAQLSAYRWGHVCEQLVREILEAAYAYV------GDHFASLIASDS 1347
                     ||.:  .|.:|..||         :..|:::.|....|      |...:.|...|.
Human   912 ---------LDVL--SDGVLKDLS---------EFYRKMIPAMDRRVITPYQDGPDISYLEVEDG 956

  Fly  1348 FLSLGHDRSRHIPRLETLL--LHTAAELTPEQACRS---YQRVTRLNTVLQAKVIHMPASLG--Q 1405
            .:.|..:.:......||:.  ..|.|:..|.:...|   |    .|:.::|:     |:|.|  :
Human   957 DIFLKEEINMEQNHSETMFKKAKTKAKKKPRKRSDSSGGY----NLSDIIQS-----PSSTGLLK 1012

  Fly  1406 SELARELQGLQEEQLDWQPEYIRLVGALVYAVEQCLIRQCSRAMRVTAWQRMDLE---------- 1460
            |.....::.|.|                       |:...|...........||:
Human  1013 SGKTNSVESLPE-----------------------LLTSDSEGSYAGVGSPRDLQSPDFTTGFHS 1054

  Fly  1461 --LRKKIQTLARLTEPL----DMKRQNGKPVGK---------------------AFSFGGSTRSQ 1498
              :..|::.....|.|:    |:|.....|:.|                     |.||  |..|.
Human  1055 DKIEAKVKPYVNGTSPVYSREDLKPWEKSPILKISAPQPIPSNRIDTTSSASWVAGSF--SPVSP 1117

  Fly  1499 DLVQIKLAIQAQTKRANAQETLMYKATQTQDAAGGAGHV-QTADRGVQANHESREGGSKLLKSNS 1562
            .:|.::..::.:..|...             .|....|: :|...||:.:.:.|:..:...|.|:
Human  1118 PVVDLRTIMEIEESRQKC-------------GATPKSHLGKTVSHGVKLSQKQRKMIALTTKENN 1169

  Fly  1563 RAYVPHRASSQVATERNSLNLHRRTQSEAPPVTHKKPITVAASTVESKSAQGKPNAAAAKLGEVR 1627
                         :..||:.....|.|:||     ||:...||::.|.|::           ..|
Human  1170 -------------SGMNSMETVLFTPSKAP-----KPVNAWASSLHSVSSK-----------SFR 1205

  Fly  1628 PRYLEPRKPRAMAPSATNGHGAGP-VRSAT------------------------------SSSIP 1661
            ...||.:|       :...|.:|. |:..:                              ||..|
Human  1206 DFLLEEKK-------SVTSHSSGDHVKKVSFKGIENSQAPKIVRWSFVLVAQAGVQWLDLSSPQP 1263

  Fly  1662 ANGGRKAPAKNLHISSSD--SSRNSSPAARRVQNGTRLGNKSSNLSMDSLASPARRAKSSSRGPQ 1724
            ...|.|..:...|.||.|  .|.:.:|...        ||..|:|.:  |.||.....||...|
Human  1264 LPPGFKRFSCLRHPSSWDYRCSTHGTPGPE--------GNHISDLPL--LDSPNPWLSSSVTAP- 1317

  Fly  1725 ERYSSDQNSLAESMKSSVITNKTISHESLSGSSKLAR-------IQQINGHS 1769
                        ||.:.| |..:|..|.|...:.|.|       :.||..|:
Human  1318 ------------SMVAPV-TFASIVEEELQQEAALIRSREKPLALIQIEEHA 1356

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG13917	NP_001189017.1	BTB	1117..>1185	CDD:279045	17/71 (24%)
		BTB	1128..>1191	CDD:197585	15/66 (23%)
		BACK	1238..>1281	CDD:197943	8/42 (19%)
IBTK	XP_006715516.1	ANK	25..135	CDD:238125
		Ank_2	25..116	CDD:289560
		ANK repeat	51..82	CDD:293786
		ANK repeat	84..116	CDD:293786
		RCC1	143..192	CDD:278826
		RCC1	195..244	CDD:278826
		ATS1	227..>458	CDD:227511	18/117 (15%)
		RCC1	247..299	CDD:278826
		BTB	554..>642	CDD:279045	18/88 (20%)
		BTB	565..>639	CDD:197585	16/74 (22%)
		BTB	761..867	CDD:279045	26/179 (15%)
		BTB	769..867	CDD:197585	22/106 (21%)
		SPOP_C_like	871..931	CDD:269810	17/105 (16%)
		GVQW	1248..>1284	CDD:290611	9/35 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910