DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13917 and KLHL18

DIOPT Version :9

Sequence 1:	NP_001189017.1	Gene:	CG13917 / 38186	FlyBaseID:	FBgn0035237	Length:	2019	Species:	Drosophila melanogaster
Sequence 2:	XP_005265058.2	Gene:	KLHL18 / 23276	HGNCID:	29120	Length:	584	Species:	Homo sapiens

Alignment Length:	364	Identity:	68/364 - (18%)
Similarity:	121/364 - (33%)	Gaps:	121/364 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1115 EDLLKMFLQEIAT----------------DMLVEVHGRRIRAHKCILRSRCQYFAAMLAG---HG 1160
            |||:...:.|:.:                |:.:::...:..||:.:|.:...||.||...   ..
Human    10 EDLVHFSVSELPSRGYGVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMEC 74

  Fly  1161 SQSVVSLQGYSYAAVHFALCHIYSGASHPPDGISLMELAALADLLGLEGLKEVTAHALKTNYCHN 1225
            .|..:.:||...:|:...:...|:| :...|..::..|...|..|.|:.:|:.....|:    ..
Human    75 KQDEIVMQGMDPSALEALINFAYNG-NLAIDQQNVQSLLMGASFLQLQSIKDACCTFLR----ER 134

  Fly  1226 FH-KPCSGCSDGILQVLPVALNHALDDLYRKCLRWTCRHYLKVWPTRQFAQLPPDILGRCRQQIV 1289
            .| |.|.|... ..:.:..|:      ||.....:..:|:::|..:.:|..||
Human   135 LHPKNCLGVRQ-FAETMMCAV------LYDAANSFIHQHFVEVSMSEEFLALP------------ 180

  Fly  1290 AYMTSDTVLDTVLDC---DHLLAQLSAYRWGHVCEQLVREILEAAYAYVGDHFASLIASDSFLSL 1351
                    |:.||:.   |.|..:..            .::.|||.|:|
Human   181 --------LEDVLELVSRDELNVKSE------------EQVFEAALAWV---------------- 209

  Fly  1352 GHDRSRHIPRLETLLLHTAAELTPEQACRSYQRVTRLNTVLQAKVIHMPASLGQSELAR---ELQ 1413
            .:||.:..|.|..||.:....|     ||......|:.               |.:|.|   :.:
Human   210 RYDREQRGPYLPELLSNIRLPL-----CRPQFLSDRVQ---------------QDDLVRCCHKCR 254

  Fly  1414 GLQEEQLDW---------------QPEYIRLVGALVYAV 1437
            .|.:|..|:               :|.....:..|:|||
Human   255 DLVDEAKDYHLMPERRPHLPAFRTRPRCCTSIAGLIYAV 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13917	NP_001189017.1	BTB	1117..>1185	CDD:279045	15/86 (17%)
		BTB	1128..>1191	CDD:197585	14/65 (22%)
		BACK	1238..>1281	CDD:197943	8/42 (19%)
KLHL18	XP_005265058.2	BTB	28..131	CDD:279045	20/103 (19%)
		PHA03098	34..562	CDD:222983	64/340 (19%)
		BACK	140..242	CDD:285009	30/161 (19%)
		KELCH repeat	282..327	CDD:276965	4/12 (33%)
		Kelch	289..341	CDD:128874	4/5 (80%)
		Kelch_1	330..375	CDD:279660
		KELCH repeat	331..374	CDD:276965
		KELCH repeat	378..427	CDD:276965
		Kelch	394..440	CDD:128874
		KELCH repeat	430..474	CDD:276965
		Kelch	441..486	CDD:128874
		KELCH repeat	477..521	CDD:276965
		Kelch_1	477..520	CDD:279660
		Kelch_1	523..567	CDD:279660
		KELCH repeat	524..567	CDD:276965
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910