DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13917 and AgaP_AGAP003645

DIOPT Version :9

Sequence 1:	NP_001189017.1	Gene:	CG13917 / 38186	FlyBaseID:	FBgn0035237	Length:	2019	Species:	Drosophila melanogaster
Sequence 2:	XP_562507.4	Gene:	AgaP_AGAP003645 / 1274312	VectorBaseID:	AGAP003645	Length:	1014	Species:	Anopheles gambiae

Alignment Length:	1095	Identity:	199/1095 - (18%)
Similarity:	341/1095 - (31%)	Gaps:	375/1095 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1092 ASSFSRSGMDESSLSCRQPRRLGEDLLKMFL---QEIATDMLVEVHGRRIRAHKCILRSRCQYFA 1153
            ||:.:.:..|...::...|....|.|..||:   ..:.||:.:||......|||.:|.:...||.
Mosquito    86 ASNAATAREDLGDMAFYMPNYSREVLKMMFMMRSHHMLTDVTLEVEQETFHAHKVVLSAASPYFK 150

  Fly  1154 AMLAG---HGSQSVVSLQGYSYAAVHFALCHIYSGASHPPDGISLMELAALADLLGLEGLKEVTA 1215
            ||..|   ....:.|.|||....|:...|..:|:|.....: :::.:|...|.:..:..:.:...
Mosquito   151 AMFTGGLKECEMARVKLQGVCPTAMTRILFFMYTGQIRVTE-LTVCQLLPAATMFQVPNVIDACC 214

  Fly  1216 HALK-----TNYCHNFHKPCSGCSDGILQVLPVALNHALDDLYRKCLRWTCRHYLKVWPTRQFAQ 1275
            ..|:     ||               .:.:...|..|..:.|.:|..::..|::.::....:|.|
Mosquito   215 DFLERQLDPTN---------------AIGIANFAEQHGCESLRQKANQFIERNFTQICREEEFLQ 264

  Fly  1276 LPPDILGRCRQQIVAYMTSDTVLDTVLDCDHLLAQLSAYRWGHVCEQLVREILEAAYAYVGDHFA 1340
            |..       .|::..:..|              :|:.        |..|::.:|...:|
Mosquito   265 LSV-------MQLICLIRKD--------------ELNV--------QGERDVYDAVLKWV----- 295

  Fly  1341 SLIASDSFLSLGHDRSRHIPRLETLLLHTAAE-LTP----EQ-----------ACRSYQRVTRLN 1389
                       .:|.....|::|::|.....: |||    ||           .||.|
Mosquito   296 -----------KYDEDNRYPKMESILSAVRCQLLTPSFLKEQMKNCAVLRRAPGCREY------- 342

  Fly  1390 TVLQAKVIHMPASLGQSELARELQ-----------GLQEEQLDWQPEYIRLVGALVYAVEQCLIR 1443
               .||:.| ..:|.:....||.:           |..:..||      .|.|   |.|:.
Mosquito   343 ---LAKIFH-DLTLHKRPAVRERKPNTTRMIFVAGGYYKHSLD------MLEG---YNVDD---- 390

  Fly  1444 QCSRAMRVTAWQRMDLELRKKIQTLARLTEPLDMKRQNGKPVGKAFSFG------------GSTR 1496
                    ..|           .||.:||.|     ::|  :|.||..|            ||:.
Mosquito   391 --------KVW-----------LTLPKLTVP-----RSG--LGAAFLKGTFYAVGGRNNSPGSSY 429

  Fly  1497 SQDLVQ------------IKLAIQAQTKRANAQETLMYKATQTQDAAGGAG----H--------- 1536
            ..|.|.            ..:::..........:.|:|       |.||:.    |
Mosquito   430 DSDWVDRYNPVTERWRPCSPMSVPRNRVGVAVMDELLY-------AVGGSSGSDYHNTVEYYDPE 487

  Fly  1537 ---------VQTADRGVQANHESR--------EGGSKLL-------KSNSRAYVP----HRASSQ 1573
                     :|:...||.....:|        :|.::|.       ::|:...||    .|:.:.
Mosquito   488 TDRWTLVQPMQSKRLGVGVAVVNRLLYAIGGFDGKTRLASVECYHPENNAWTLVPPMRYGRSGAG 552

  Fly  1574 VATERNSLNLHR------------------RTQSEAPPVTHKKPITVAASTVESKSAQGKPNAAA 1620
            ||.      ||:                  |..:|........|:.:|.|.:......|:..|..
Mosquito   553 VAA------LHQYIYVVGGFDGTRQLASVERYDTEQQCWEMVAPVRIARSALSLTVLDGRLYAIG 611

  Fly  1621 AKLGEVRPRYLEPRKPRAMAPSATNGHGAGPVRSATSSSIPANGGRKAPA--------------K 1671
            ...|:.....:|.               ..|||.......|...||...|              :
Mosquito   612 GYDGQDFLTIVEV---------------YDPVRDVWDEGTPLTSGRSGHASAVIYTPSCISSYME 661

  Fly  1672 NLHISSSDSSRNSSPAARRVQNGTRLGN-------KSSNLSMDSLASPARRAKSSSRGPQERYSS 1729
            .|::...:..|:.|      .:|...|.       .||:.|....::||..:.|||.      ||
Mosquito   662 GLNLGGGEEKRSDS------GDGGGTGQPQQPPPPPSSSSSSQQASAPAPPSSSSSS------SS 714

  Fly  1730 DQNSLAESMKSSVITNKTISHESLSGSSKLARIQQINGHSKGAATGKIKA----TQRGSTVGNKS 1790
            ...|...:..:...:..|.|.|.::..|        .|...||:.|.::|    |:.........
Mosquito   715 SAPSCTSASGTHASSRPTDSGEEMTAGS--------GGGGGGASDGPMEAQVVETEEEPFAMETD 771

  Fly  1791 TRQLKQQHNAMASNGSSPSSVHTTKSAASRLSS---------VSSTLSTRE---LFKQRSISVPA 1843
            :.|.:...:...|:|....|     |||..|..         |:.:|:..|   :.:...:.:|:
Mosquito   772 SSQEECDKDVTVSDGDGIRS-----SAAVPLEGAPPPDIPPPVALSLAVVERCPVVRSADLLLPS 831

  Fly  1844 GGTDGAPNKGRHSFLSAKSREILAKRAEKNKLQQQQQQQKQTEAPVEERGSVQLRSSAGPLRSSS 1908
                           |..:|.||:.|            |:......:||.|    |:|.|..|..
Mosquito   832 ---------------SRLTRRILSCR------------QRSKRCSGKERSS----SAASPSPSRC 865

  Fly  1909 HSAVSSMLQQHNLRNSLPSNIPTRRPNTLHLKKTTAATNGVGGG--PTKTTTNGMSNGTYKSAQA 1971
            ....||...::.|     :..||.|      |:..:.:.|.|||  ..:....|.:...:.....
Mosquito   866 PKRSSSSAARYTL-----TLAPTSR------KEAPSGSAGAGGGCKSKRKAAGGTATDDHCPLVR 919

  Fly  1972 VKQKLDLLIDAQM---------ESVVPRERVESKLERSSTFCKDSADLDISELQI 2017
            :|:::..|:.|.:         .:.:|........|.|||...:|...|.:...|
Mosquito   920 LKKRITCLVSAIVSPTSSSSCSSAALPSPPALLSEESSSTTATNSNSSDSNSANI 974

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13917	NP_001189017.1	BTB	1117..>1185	CDD:279045	23/73 (32%)
		BTB	1128..>1191	CDD:197585	20/65 (31%)
		BACK	1238..>1281	CDD:197943	8/42 (19%)
AgaP_AGAP003645	XP_562507.4	PHA03098	112..633	CDD:222983	115/659 (17%)
		BTB	114..217	CDD:279045	25/103 (24%)
		BACK	226..328	CDD:285009	24/146 (16%)
		Kelch	369..413	CDD:128874	17/82 (21%)
		KELCH repeat	403..450	CDD:276965	9/48 (19%)
		Kelch	416..464	CDD:128874	4/47 (9%)
		KELCH repeat	454..497	CDD:276965	6/49 (12%)
		Kelch	465..510	CDD:128874	9/51 (18%)
		KELCH repeat	501..545	CDD:276965	8/43 (19%)
		Kelch	512..557	CDD:128874	8/50 (16%)
		KELCH repeat	548..590	CDD:276965	7/47 (15%)
		Kelch	560..605	CDD:128874	5/44 (11%)
		KELCH repeat	595..638	CDD:276965	8/57 (14%)
		Kelch	606..650	CDD:128874	10/58 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910