DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13917 and abtb1

DIOPT Version :9

Sequence 1:	NP_001189017.1	Gene:	CG13917 / 38186	FlyBaseID:	FBgn0035237	Length:	2019	Species:	Drosophila melanogaster
Sequence 2:	XP_003199099.1	Gene:	abtb1 / 100536189	ZFINID:	ZDB-GENE-141212-241	Length:	476	Species:	Danio rerio

Alignment Length:	448	Identity:	87/448 - (19%)
Similarity:	156/448 - (34%)	Gaps:	137/448 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1064 LPNGMTLE--QVQGQQVDYIQTDLSADSSLASSFSRSGMDESSLSCRQPRRLGEDLLKMFLQEIA 1126
            |.||...|  ...|::..|        .:|:.:..|...:...::.:..:|   |....|||.:.
Zfish    56 LANGAKCEANTFDGERCLY--------GALSDAIRRLLKEYKRITAKAMQR---DYYDQFLQTLL 109

  Fly  1127 -----TDMLVEVHGRRIRAHKCILRSRCQYFAAML--AGHGSQSVV------------SLQGYSY 1172
                 :|:...|||...:||:|||.:|.:|||.||  ...|..::.            ::..|.|
Zfish   110 EQGNYSDVTFVVHGEMFKAHRCILSARSEYFAHMLETKWKGKSAIALKHPLVNPAAFGAIMQYFY 174

  Fly  1173 AA-----VHF---------------------ALC-HIYSGASHPP-----------------DGI 1193
            ..     |::                     ..| .:|...|:.|                 ||:
Zfish   175 TGRLDIDVNYVEDCKRLAKQCKIGELIEELEVKCKQVYEFVSNKPGTCVKVLTLDPHDFQLQDGM 239

  Fly  1194 SLMELAAL-ADL----------------------LGLEGLKEVTAHALKTNYC--HNFHKPC--S 1231
            :|:..:|| |:|                      ..:||. :...|  |..:|  .::.|..  .
Zfish   240 ALLADSALPAELRVGYGQLPFDLTDSFPSYPDICFRVEGY-DFLCH--KAFFCGRSDYFKALLED 301

  Fly  1232 GCSDG-ILQVLP----VALNHALDDLYRKCLRW-----TCRHYLKVWPTRQFAQ--LPPDILGRC 1284
            ..|:| .||..|    :.|:....||:.:.|.:     |...:..|:.....|.  |.|.:...|
Zfish   302 HFSEGETLQTHPSIPVITLHDVSHDLFTRILYYIYSDNTQLSHENVYEVLCVADMYLLPGLKRLC 366

  Fly  1285 RQQIVAYMTSDTVLDTVLDCDHLLAQLSAYRWGHV---CEQLVREILEAAYAYVGDHFASLIASD 1346
            .:.:.|.:..:.||       |:......:|...:   |.:.:.:|:|....  ...||.:|..|
Zfish   367 GRTLAALLNEENVL-------HMWRTAKLFRLSRLEDQCTEHMAKIIERLVE--RPEFADMIRED 422

  Fly  1347 SFLSLGHDRSRHIPRLETLLLHTAAELTPEQACRSYQRVTRLNTVLQAKVIHMPASLG 1404
            :........:..||.::.:..|.|:.:      ::|..:...|..|.|..: :.||:|
Zfish   423 AGNVAARQETDSIPLVDEIRFHIASNV------QTYSAIEEANQKLSALEL-LLASIG 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13917	NP_001189017.1	BTB	1117..>1185	CDD:279045	24/113 (21%)
		BTB	1128..>1191	CDD:197585	23/120 (19%)
		BACK	1238..>1281	CDD:197943	12/53 (23%)
abtb1	XP_003199099.1	Ank_2	6..94	CDD:289560	8/45 (18%)
		ANK	6..94	CDD:238125	8/45 (18%)
		ANK repeat	35..66	CDD:293786	4/9 (44%)
		BTB	105..209	CDD:279045	21/103 (20%)
		BTB	116..210	CDD:197585	20/93 (22%)
		BTB	268..370	CDD:279045	21/104 (20%)
		BTB	271..370	CDD:197585	21/101 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910