DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13917 and Btbd8

DIOPT Version :9

Sequence 1:	NP_001189017.1	Gene:	CG13917 / 38186	FlyBaseID:	FBgn0035237	Length:	2019	Species:	Drosophila melanogaster
Sequence 2:	NP_001365195.1	Gene:	Btbd8 / 100503185	MGIID:	3646208	Length:	1751	Species:	Mus musculus

Alignment Length:	1144	Identity:	268/1144 - (23%)
Similarity:	445/1144 - (38%)	Gaps:	265/1144 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   999 KSVGNNHR-----SSQLGQ---RLYRDE-----------NRARPH-SWAMTRSTG-------NTL 1036
            |..|...|     |.||.:   ||.|:|           :..:.| :..:.|:.|       :|.
Mouse    28 KGPGERRRLKAAVSEQLSRDVLRLLREEIHTDTILSVSGSLFKVHKAVLLARAPGFHSHIIEHTS 92

  Fly  1037 QNFTNS---VDNIR------------SLSRLFPNFSKEFSNSLPNGMTLEQVQGQQVDYIQTDLS 1086
            .:.||.   ||.:.            |.::...|:.:|....|..|..:.: :|..|.:.:...|
Mouse    93 SDLTNELVPVDGVEASEFKAFLQIVYSSNKNIKNYEEEIVKKLKVGSLMPE-KGPDVSFPRYRTS 156

  Fly  1087 ADSSLASS-------------FSRSGMDESSLSCRQPRRLGEDLLKMFLQEIATDMLVEVHGRRI 1138
            :|..|...             .|::..|....|     .||.||||::|.:...|:.:.|.||..
Mouse   157 SDCFLGKGEIPEDITGGGDCFISKADSDLEPAS-----ELGGDLLKLYLSQHYPDIDICVDGRSF 216

  Fly  1139 RAHKCILRSRCQYFAAMLAG---HGSQSVVSLQGYSYAAVHFALCHIYSGASHPPDGISLMELAA 1200
            |||:.||.:|..||||||:|   ..||..::|||.::..::..:..||.|....|:..::.::..
Mouse   217 RAHRAILSARSSYFAAMLSGCWAESSQECITLQGITHVEMNVMMHFIYGGTLDFPEKANVGQILN 281

  Fly  1201 LADLLGLEGLKEVTAHALKTNYCHNFHKPCSGCSDGILQVLPVALNHALDDLYRKCLRWTCRHYL 1265
            :||:.|||||:||..:.|:.:||:.|.||.......||:.|.:|.:..::.|:..|:.....|:.
Mouse   282 VADMYGLEGLREVAIYVLRRDYCNFFQKPVPRTWASILECLIIAHSVGVESLFADCMNCIISHFA 346

  Fly  1266 KVWPTRQFAQLPPDILGRCRQQIVAYMTSDTVLDTVLDCDHLLAQLSAYRWGHVCEQLVREILEA 1330
            :.|..|.||.:||:|...|....:..:........:::.|.|:..|...:|......:..::.|.
Mouse   347 RFWSERSFANVPPEIQKTCLSMQIQSLNHGNAAFLLMESDRLIMGLPRVKWTEAALSMASQLQEE 411

  Fly  1331 AYAYVGDHFASLIASDSFLSLGHDRSRHIPRLETLLLHTAA-----------------ELTPEQA 1378
            ...::.::|:.:|.|::|               ||||.:.|                 .:|.|.:
Mouse   412 CVTFIVENFSQIIESENF---------------TLLLQSQAMSSTAHLLDKIFKAIEDNITAENS 461

  Fly  1379 CRSYQRVTRLNTVLQAKVIHMPASLGQSELARELQGLQEEQLDWQPEYIRLVGALVYAVEQCLIR 1443
            |   ..:..|:|:|            .||..:|: |....        |:.|...::|    .:.
Mouse   462 C---SLLMALDTLL------------NSESTKEM-GFTCR--------IQAVRGKLWA----FLV 498

  Fly  1444 QCSRAMRVT-AWQRMDLELRKKIQTLARLTEPLDMKRQNGKPVGKAFSFGGSTRSQ------DLV 1501
            |...|:|.| :|:.|.|:.::|||..|  .:..|.:|...|||        .|.||      |:.
Mouse   499 QSFYAVRHTGSWKLMHLDDQQKIQVAA--LDKGDDRRLGRKPV--------LTSSQQRRQGSDVD 553

  Fly  1502 QIKLAIQAQTKRANAQETLMYKATQTQDAAGGAGHVQTADRGVQANHESREGGS-------KLLK 1559
            .:|:....:..:...|.:|........|..|.:||..:.:|. ..|..|:.|.|       |.:|
Mouse   554 VLKIKPWTENNKKPCQTSLSTNQKMRSDGLGASGHASSTNRN-SINKVSKHGDSTKMSKVVKEMK 617

  Fly  1560 SNSRAYVPHRASSQVATERNSLNLHRRTQSEAPPVTHKKPITVAASTVESKSAQGKPNAAAAKLG 1624
            :..: ||..::.:.|..:..:.: |.:.:..:..|..:.....||...:....:|..|......|
Mouse   618 TGGK-YVSGKSKTMVKPQTENSD-HTKIEGLSSTVVGRPSRVTAAGRKDPVHGKGVQNQEVETTG 680

  Fly  1625 EVRPRYLEPRKPRAMAPSATNGHGAGPVRSATSSSIPANGGRKAPAKNLH-ISSSDSSRNSS--P 1686
             .||:.|                             .||...:|.||.|. :...||:..:|  |
Mouse   681 -ARPKVL-----------------------------TANLNVQARAKPLQTLRGKDSTCPASVGP 715

  Fly  1687 AARRVQNGTRL----GNKSSNLSMDSLASPARRAKS-SSRGPQERYSSDQNSLAESMKSSVI--- 1743
            ::|...:.|.|    |:........|:....|..|. .|..|.:..|:...|.| ::||..:
Mouse   716 SSRSTHSSTELLASMGSVDETKENGSVEDKCRDGKPYVSDSPGQMVSNGVMSTA-AVKSRAVARI 779

  Fly  1744 -----TNKTISHESLS-GSSKLARIQQINGHSKGAATGKIKATQRGSTVG-------NKSTRQLK 1795
                 :||:.:||..| |:|.:  |::.:|....|:..:..|.:|||:.|       .||.....
Mouse   780 TNGTASNKSFTHEQDSHGNSSV--IKRGDGKGLSASAPQTAAKKRGSSNGCTAAQPRTKSAPPTL 842

  Fly  1796 QQHNAMASNGSSPSSVHTTKSAASRLSSVSSTLSTRELFKQRSISVPAGGTDGAPNKGR-----H 1855
            .|  |..|.|.||.||.         |||||..|...:.:.|.      |||....|.:     |
Mouse   843 AQ--AQGSQGESPHSVK---------SSVSSRQSDENVTRLRH------GTDKQIPKRKVVKQGH 890

  Fly  1856 SFLSAKSREILAKRAEKNKLQQQ--------QQQQKQTEAPVEERGSVQLRSSAGPLRSSSHSAV 1912
            :.|    :::.||.....|:..|        .:..||...|    |.:.|:|.|....|....|.
Mouse   891 TTL----QKVNAKLVPMPKIPSQPKKGGTVNSKDSKQKVLP----GQIMLQSHASQRPSKPEVAE 947

  Fly  1913 SSMLQQHNL---RNSLPSNIPTRRPNTLHLKKTTAATNGVGGGPTKTTTNGMSNGTYKSAQAVKQ 1974
            .|:|  |.:   ||.:....|...|.||....:....:.:...|...:..|...         |:
Mouse   948 KSVL--HGVSDSRNHVSKQRPHESPCTLACDTSGPEVSQIPCRPQPQSPLGSQE---------KK 1001

  Fly  1975 KLDLLID--AQMESVVPRE-RVE-SKLERSSTFC-KDSA 2008
            :|:|...  :.:...|.|| |.| :.:|:|.|.. |||:
Mouse  1002 RLELACQDRSTLGDSVKRELRSELAGIEQSHTSAYKDSS 1040

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13917	NP_001189017.1	BTB	1117..>1185	CDD:279045	28/70 (40%)
		BTB	1128..>1191	CDD:197585	25/65 (38%)
		BACK	1238..>1281	CDD:197943	12/42 (29%)
Btbd8	NP_001365195.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	13..37		3/8 (38%)
		BTB1_POZ_BTBD8	43..146	CDD:349594	19/103 (18%)
		BTB2_POZ_BTBD8	188..308	CDD:349595	46/124 (37%)
		BACK_BTBD8	316..377	CDD:350565	15/60 (25%)
		BACK	<405..436	CDD:350515	9/45 (20%)
		DUF4596	1707..1751	CDD:405945
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9741
eggNOG	1	0.900	-	-		E1_2CN92
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007444
OrthoInspector	1	1.000	-	-		oto92821
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5772
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.840