DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13917 and klhl21

DIOPT Version :9

Sequence 1:	NP_001189017.1	Gene:	CG13917 / 38186	FlyBaseID:	FBgn0035237	Length:	2019	Species:	Drosophila melanogaster
Sequence 2:	XP_002933898.2	Gene:	klhl21 / 100495738	XenbaseID:	XB-GENE-5802687	Length:	615	Species:	Xenopus tropicalis

Alignment Length:	663	Identity:	122/663 - (18%)
Similarity:	211/663 - (31%)	Gaps:	224/663 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1088 DSSLASSFSRSGMDESSLS-----CRQPRRLGEDLLKMFLQEIATDMLVEVHGRRIRAHKCILRS 1147
            |:.:.:|.|.:|:..|..|     ......|...:.::..::...||.|...|:....|:.:|.:
Frog     2 DTPINTSPSSAGIPASEASLPFYDASHALHLLRGINELRAEQKFFDMTVSAGGQDFPCHRTVLAA 66

  Fly  1148 RCQYFAAMLAGHGSQS---------------------------VVSLQG----------YSYAAV 1175
            ...||.||.||...:|                           .|:|:.          :.:.:|
Frog    67 ASNYFRAMFAGRLRESHVDRVELHDVTGPILSLLLDFCYTGRVTVTLENVEPLLQAADLFQFPSV 131

  Fly  1176 HFALCHIYSGASHPPDGISLMELAALADLLGLEGLKEVT-----AHALKTNYCH-----NFHKPC 1230
            ..|.|   :......|..:.:|:...|:....:||.|.|     ||..:....|     .|.:..
Frog   132 KEACC---AYLEQQLDVSNCLEIQDFAEAYACQGLAESTKRFILAHMAQLAQAHEVERLTFKRML 193

  Fly  1231 SGCSDGILQV------LPVALNHALDDLYRKCLRW-TCRHYLKVWPTRQFAQLPPDILGRCRQQI 1288
            ...||..|.|      ..:||.....|...:..|| ....||::...|:|             .:
Frog   194 EYISDDRLCVDKEEAAFQIALQWVKADPKHRQYRWPELFQYLRLPFIRRF-------------YL 245

  Fly  1289 VAYMTSDTVLDTVLDCDHLLAQLSAYR--------W-----------------------GHVCEQ 1322
            :||:.||.::.....|..|:.:..|::        |                       ...|::
Frog   246 LAYVESDPLVYRSPYCLQLIREARAFQSSEYDRHDWPCHRMKPRPSTGLAEILVVVGGCDQDCDE 310

  Fly  1323 LV------------REILEAAYAYVGDHFASLIASDSFLSLGHDRSR---HIPRLETLLLHTAAE 1372
            ||            |.:.|......|.:..:.:.:|.:::.|.|.||   .:.|..: .::...|
Frog   311 LVTVDCYNAQTGQWRYLAEFPDHLGGGYSITALGNDIYVTGGSDGSRLYDCVWRYNS-SVNEWTE 374

  Fly  1373 LTPEQACRSYQRVTRLNTVLQAKVIHMPASLGQSELARELQGLQEEQLD-WQPEYIRLVGALVYA 1436
            ::|....|.|...|.||.:|..             :|.:.....:..:| |  |.:|   .::|.
Frog   375 VSPMLKAREYHSSTVLNGLLYV-------------IASDSTERYDPTMDTW--ESLR---PMLYP 421

  Fly  1437 VEQCLIRQCSRAMRVTAWQRMDLELRKKIQTLARLTEPLDMKRQNGKP---------VGK--AFS 1490
            ::.|....|                |||:..:..|.....|..|...|         .|:  .:|
Frog   422 MDNCSTTSC----------------RKKLYAIGSLEGKESMVMQCYNPDTNLWSMVNCGQLPPWS 470

  Fly  1491 FGGSTRSQDLVQIKLAIQAQTKRANAQETLMYKATQTQ----------------DAAGG-----A 1534
            |...|       :.|.......|.::.|..:|..::.:                .|.||     .
Frog   471 FAPKT-------VTLNGLIYFVRDDSAEVDVYSPSKNEWDKIPPMIQVHVGGSLAALGGKLYVSG 528

  Fly  1535 GHVQTADRG--VQA-NHESR--------------EGGSKLLKSNSRAYVPHRASS-------QVA 1575
            |:..|.:..  |:| :.|:|              .|...:.    |.::|....|       .|.
Frog   529 GYDNTFELSDVVEAFDPETRLWSLVGRLPQPTFWHGSVSIF----RQFMPQTQYSLDGVPLDNVN 589

  Fly  1576 TERNSLNLHRRTQ 1588
            .|||.:||:||.|
Frog   590 NERNVINLNRRRQ 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13917	NP_001189017.1	BTB	1117..>1185	CDD:279045	18/104 (17%)
		BTB	1128..>1191	CDD:197585	18/99 (18%)
		BACK	1238..>1281	CDD:197943	11/49 (22%)
klhl21	XP_002933898.2	BTB_POZ_KLHL21	25..148	CDD:349559	20/125 (16%)
		PHA03098	43..557	CDD:222983	102/571 (18%)
		BACK_KLHL21	143..243	CDD:350535	23/99 (23%)
		KELCH repeat	336..378	CDD:276965	8/42 (19%)
		KELCH repeat	382..419	CDD:276965	11/54 (20%)
		KELCH repeat	422..461	CDD:276965	9/54 (17%)
		KELCH repeat	512..558	CDD:276965	9/45 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910