DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13917 and klhl6

DIOPT Version :9

Sequence 1:	NP_001189017.1	Gene:	CG13917 / 38186	FlyBaseID:	FBgn0035237	Length:	2019	Species:	Drosophila melanogaster
Sequence 2:	XP_002933397.2	Gene:	klhl6 / 100486936	XenbaseID:	XB-GENE-983196	Length:	610	Species:	Xenopus tropicalis

Alignment Length:	596	Identity:	104/596 - (17%)
Similarity:	190/596 - (31%)	Gaps:	196/596 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1104 SLSCRQPRRLGE-----------------------DLLKMFLQEIATDMLVEVHGRRIRAHKCIL 1145
            ||:...|:.|||                       .|..:.|:...||:::.|..:....|:.:|
Frog    15 SLNSECPKELGELIENSSGDNRKFDDTGFTLALQSGLENLRLENSLTDVVLCVGDKVFPCHRVVL 79

  Fly  1146 RSRCQYFAAMLAG---HGSQSVVSLQGYSYAAVHFALCHIYSG--ASHPPDGISLMELAALADLL 1205
            .:...||.||...   ...:..:.:||.....:...|.:.|:.  .....:...::|.|:|...|
Frog    80 AAASNYFRAMFCNDLKEKYEEKIIIQGVEPETMQIILDYTYTSKVVITKLNVQKILEAASLFQFL 144

  Fly  1206 GL-EGLKEVTAHALKTNYCHNFHKPCSGCSDGILQVLPVALNHALDDLYRKCLRWTCRHYLKVWP 1269
            .: :........||....|              :.:|.:|..|:|:.|..:...:..:::.:|..
Frog   145 RMVDACSSFLTEALHPENC--------------VGILRLADAHSLESLKVQVQNYIIQNFSQVLN 195

  Fly  1270 TRQFAQLPPDILGRCRQQIVAYMTSDT-------------------VLDTVLDCDHLLAQLSAYR 1315
            ...|.:||.:||....:....|:|.:.                   :|..:::|..|......|.
Frog   196 QEDFFELPFEILFHMLKSDDLYVTEEAQVFETVINWVEYKKSERLELLPKIMECVRLPLLDPWYL 260

  Fly  1316 WGHV-CEQLVRE------ILEAAYAYVGDHFASLIASDSFLSLGHDRSRHIPRL-----ETLLLH 1368
            .|:| ..:|:|:      :::.|..|       .:|.:..:|   :|::  ||:     |..::.
Frog   261 VGNVEANELIRQCPDVFPLMQEARIY-------YMAGNEVIS---ERTK--PRIHEFQSEVFMII 313

  Fly  1369 TAA----ELTPEQACRSYQRVTRLNTVLQAKVIHMPASLGQSELARELQGLQEEQLDWQPEYIRL 1429
            ...    :...|..|....|.:||      :|..:|.|..::|         .|...|
Frog   314 GGCTKDEKFVTEVTCLDPLRRSRL------EVAKLPVSDHENE---------SENKKW------- 356

  Fly  1430 VGALVYAVEQCLIR-------QCSRAMRVTAWQRMDLELRKKIQTLARLTEPLDMKRQNGKPV-- 1485
                   ||...|.       ...:..:...| :.:..:.|.||     .|.|::.|...|..
Frog   357 -------VEFACITFKNEVYISGGKDTQQEVW-KYNSSINKWIQ-----IEYLNVGRWRHKMAAL 408

  Fly  1486 -GKAFSFGGSTRSQDLVQIK--------------LAIQAQTKRANAQETLMYKATQTQDAAGGAG 1535
             ||.::.||...||.:..::              |.|.|.:..|...:..:|       ..||..
Frog   409 CGKVYAIGGFDGSQRIYSVEVYDPFHNGWTEVAPLLISASSFAAACHQKKLY-------VIGGGP 466

  Fly  1536 HVQTADRGVQANHESREGGSKLLKSNSRAYVPHRASSQVATERNSLNLHRRTQSEAPPVTHKKPI 1600
            :                  .||....::.|.|         |.|...|             |.|:
Frog   467 N------------------GKLATDKTQCYDP---------ETNKWCL-------------KSPM 491

  Fly  1601 TVAASTVESKS 1611
            .|.|..:.:.|
Frog   492 PVEAKCINAVS 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13917	NP_001189017.1	BTB	1117..>1185	CDD:279045	15/70 (21%)
		BTB	1128..>1191	CDD:197585	12/67 (18%)
		BACK	1238..>1281	CDD:197943	9/42 (21%)
klhl6	XP_002933397.2	BTB_POZ_KLHL6	37..165	CDD:349545	22/141 (16%)
		PHA03098	63..554	CDD:222983	94/548 (17%)
		BACK_KLHL6	158..265	CDD:350521	20/120 (17%)
		KELCH repeat	359..396	CDD:276965	6/42 (14%)
		KELCH repeat	400..444	CDD:276965	8/43 (19%)
		KELCH repeat	447..493	CDD:276965	14/92 (15%)
		KELCH repeat	495..531	CDD:276965	2/8 (25%)
		KELCH repeat	537..581	CDD:276965
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910