DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12004 and tmem184b

DIOPT Version :9

Sequence 1:	NP_001097474.1	Gene:	CG12004 / 38185	FlyBaseID:	FBgn0035236	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_001039137.2	Gene:	tmem184b / 733961	XenbaseID:	XB-GENE-489974	Length:	425	Species:	Xenopus tropicalis

Alignment Length:	485	Identity:	266/485 - (54%)
Similarity:	321/485 - (66%)	Gaps:	80/485 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 EAALNASSGNATATTAGSLEATGKPNYVVQVKNTPMSTPLDPLLHVGDGIFLQTKTAQVLAGVCV 74
            ||.:::...:||.|  |:: .|..||:...::..|.:        :...:||.|.|||.::|..|
Frog    12 EAGMDSRDPSATIT--GTV-TTSSPNFSRALEEQPFT--------LEQPMFLMTTTAQAISGFFV 65

  Fly    75 WAALFITCQQIYQHLRWYTNPQEQRWIVRILFIVPIYATYSWISLLFFNSDNVYIYFFTVRDCYE 139
            |.||.|||.|||.|||.|:.|.|||.||||||||||||..||:|||||.:|..|:||.|||||||
Frog    66 WTALLITCHQIYMHLRSYSCPNEQRHIVRILFIVPIYAFDSWLSLLFFTNDQYYVYFDTVRDCYE 130

  Fly   140 AFVIYNFLSLCYEYLGGEGNIMSEIRGKPIKTSCLYGTCCLKGKTYTIGFLRFCKQATLQFCLVK 204
            ||||||||||||||||||.|||:|||||||::||:||||||.||||:|||||||||||||||:||
Frog   131 AFVIYNFLSLCYEYLGGESNIMTEIRGKPIESSCMYGTCCLWGKTYSIGFLRFCKQATLQFCVVK 195

  Fly   205 PLVAFIIIFLQAFGHYHDGDWSADGGYIYITIIYNISVSLALYGLYLFYFATRDLLTPFEPVLKF 269
            ||:|.:.:.|||||.|.|||::...||:|:|||||||||||||.|:|||||||:||:|:.|||||
Frog   196 PLMAAVTVILQAFGKYRDGDFNVASGYLYVTIIYNISVSLALYALFLFYFATRELLSPYSPVLKF 260

  Fly   270 CTIKSVIFLSFWQGVGLAILEKANVISPIVDSAGTVTVEPGTVSAGYQNFFICIEMLFAAIALRY 334
            ..:|||||||||||:.|||:||...| |.:||| .|:|..|||:||||||.||:||.||||||||
Frog   261 FMVKSVIFLSFWQGMLLAIMEKCGAI-PKIDSA-EVSVGEGTVAAGYQNFIICVEMFFAAIALRY 323

  Fly   335 AFPYQVY------ARSCISDG-HGRSVTMQSISSSLKETMNPKDIMTDAIHNFHPQYQQYTQYSS 392
            ||.|:||      |::..:.| :||...|:||||||||||||.||:.||||||.|.||||||.|:
Frog   324 AFTYKVYLDKRLDAQAVPTYGPYGRCAPMKSISSSLKETMNPHDIVQDAIHNFSPAYQQYTQQST 388

  Fly   393 --GGKNSRGIRVSSYDPDDPSSGAAAGGMQASQPTSGGYDAVATGPGSGGNGGSNCMASKTLGNQ 455
              .|.:.|..::.|                .||..||..|
Frog   389 LEQGSSWRNGQIIS----------------RSQSVSGARD------------------------- 412

  Fly   456 RKFQPGGQRVATISQNYNEKTMLLSSDDEY 485
                             .|||:|||||||:
Frog   413 -----------------TEKTLLLSSDDEF 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12004	NP_001097474.1	Solute_trans_a	66..339	CDD:397604	198/272 (73%)
tmem184b	NP_001039137.2	Solute_trans_a	57..328	CDD:367581	198/272 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	411	1.000	Domainoid score	I674
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6396
Inparanoid	1	1.050	480	1.000	Inparanoid score	I1431
OMA	1	1.010	-	-		QHG55062
OrthoDB	1	1.010	-	-		D411703at33208
OrthoFinder	1	1.000	-	-		FOG0000529
OrthoInspector	1	1.000	-	-		otm48860
Panther	1	1.100	-	-	O	PTHR23423
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1529
SonicParanoid	1	1.000	-	-		X1310
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110