DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12004 and TMEM184A

DIOPT Version :9

Sequence 1:	NP_001097474.1	Gene:	CG12004 / 38185	FlyBaseID:	FBgn0035236	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_001091089.1	Gene:	TMEM184A / 202915	HGNCID:	28797	Length:	413	Species:	Homo sapiens

Alignment Length:	473	Identity:	245/473 - (51%)
Similarity:	311/473 - (65%)	Gaps:	73/473 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 ATTAGSLEATGKPNYVVQVK----NTPMSTPLDPLL-HVGDG------IFLQTKTAQVLAGVCVW 75
            :..:|.||..|.|  :|...    :.|.:.|..|.: |:|:.      :||.:..|:.::|:.||
Human     2 SNVSGILETAGVP--LVSANWPQPSPPPAVPAGPQMDHMGNSSQGAPWLFLTSALARGVSGIFVW 64

  Fly    76 AALFITCQQIYQHLRWYTNPQEQRWIVRILFIVPIYATYSWISLLFFNSDNVYIYFFTVRDCYEA 140
            .||.:||.|||.|||.||.|||||:|:|:|.||||||..||:|||.......|:||.:|||||||
Human    65 TALVLTCHQIYLHLRSYTVPQEQRYIIRLLLIVPIYAFDSWLSLLLLGDHQYYVYFDSVRDCYEA 129

  Fly   141 FVIYNFLSLCYEYLGGEGNIMSEIRGKPIKTSCLYGTCCLKGKTYTIGFLRFCKQATLQFCLVKP 205
            ||||:|||||::||||||.||:||||||||:|||||||||:|.||:|||||||||||||||||||
Human   130 FVIYSFLSLCFQYLGGEGAIMAEIRGKPIKSSCLYGTCCLRGMTYSIGFLRFCKQATLQFCLVKP 194

  Fly   206 LVAFIIIFLQAFGHYHDGDWSADGGYIYITIIYNISVSLALYGLYLFYFATRDLLTPFEPVLKFC 270
            ::|...|.|||||.|||||::...||:|:|:|||.|||||||.|:||||.||:||.||:|||||.
Human   195 VMAVTTIILQAFGKYHDGDFNVRSGYLYVTLIYNASVSLALYALFLFYFTTRELLRPFQPVLKFL 259

  Fly   271 TIKSVIFLSFWQGVGLAILEKANVISPIVDSAGTVTVEPGTVSAGYQNFFICIEMLFAAIALRYA 335
            |||:|||||||||:.|||||:..|| |.|:::|...:..||::||||||.||:|||||::|||||
Human   260 TIKAVIFLSFWQGLLLAILERCGVI-PEVETSGGNKLGAGTLAAGYQNFIICVEMLFASVALRYA 323

  Fly   336 FPYQVYARSCISDGHGRSVTMQSISSSLKETMNPKDIMTDAIHNFHPQYQQYTQYSSGGKNSRGI 400
            ||.||||.. ..:.......||||||.::||::|:||:.||||||.|.||.|||.::
Human   324 FPCQVYAEK-KENSPAPPAPMQSISSGIRETVSPQDIVQDAIHNFSPAYQHYTQQAT-------- 379

  Fly   401 RVSSYDPDDPSSGAAAGGMQASQPTSGGYDAVATGPGSGGNGGSNCMASKTLGNQRKFQPGGQRV 465
                              .:|.:|        .|.| |||:|||.  .|::|
Human   380 ------------------HEAPRP--------GTHP-SGGSGGSR--KSRSL------------- 402

  Fly   466 ATISQNYNEKTMLLSSDD 483
                    ||.||:.|:|
Human   403 --------EKRMLIPSED 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12004	NP_001097474.1	Solute_trans_a	66..339	CDD:397604	187/272 (69%)
TMEM184A	NP_001091089.1	Solute_trans_a	55..325	CDD:281602	185/270 (69%)
TMEM184A	NP_001091089.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	372..413		22/99 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	402	1.000	Domainoid score	I733
eggNOG	1	0.900	-	-		E1_KOG2641
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	473	1.000	Inparanoid score	I1514
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55062
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000529
OrthoInspector	1	1.000	-	-		otm41643
orthoMCL	1	0.900	-	-		OOG6_100407
Panther	1	1.100	-	-	LDO	PTHR23423
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1529
SonicParanoid	1	1.000	-	-		X1310
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.860