DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7879 and Rbm12

DIOPT Version :9

Sequence 1:	NP_647626.1	Gene:	CG7879 / 38184	FlyBaseID:	FBgn0035235	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	NP_083673.3	Gene:	Rbm12 / 75710	MGIID:	1922960	Length:	992	Species:	Mus musculus

Alignment Length:	1159	Identity:	248/1159 - (21%)
Similarity:	398/1159 - (34%)	Gaps:	347/1159 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSVIIRLQNLPWTANARDIRNFFSGLSIPEGGVHIIGGEMGDAFIAFSTDEDARCAMLKDREKLM 65
            |:|:||||.||..|...|||:|||||:||:|||||:|||:|:|||.|:||||||..|::....:.
Mouse     1 MAVVIRLQGLPIVAGTMDIRHFFSGLTIPDGGVHIVGGELGEAFIVFATDEDARLGMMRTGGTIK 65

  Fly    66 EIQVRLLLSSRAEMQKVIETARKAASAQAPVSVPVPMPVVVPVTAAKVAGPAAP-------LPPI 123
            ..:|.|||||:.|||.:||.:|:.... |.:.:|       |..|::...|.:.       ||.|
Mouse    66 GSKVTLLLSSKTEMQNMIELSRRRFET-ANLDIP-------PANASRSGPPPSSGMSSRVNLPAI 122

  Fly   124 IGGLN----------TFLGQGQVKGVATGTVPSFLTYQQQAGITLSDVTGRRSRSRSSSSDDSDR 178
            :...|          |.:.:.. |.:.|.:..|..|.....|.:....|...:...::|.
Mouse   123 VPNFNNPSPSVVTATTSVHESN-KNIQTFSTASVGTAPPSMGTSFGSPTFSSTIPSTASP----- 181

  Fly   179 ERERDRQRERERGRKRRSDRLDKSQERELKMVAGGGALPS-------PWAQPPQNQLPAVGLGLN 236
                                ::......:..:....:||.       | ..||...||.|.
Mouse   182 --------------------MNTVPPPPIPPIPAMPSLPPLPSIPPIP-VPPPVPTLPPVP---- 221

  Fly   237 MGLNLNLPQIPSLQSYTTSTTTTNVTNNYNLEPSATSVQLLTALQQVSSGSAAPAQPSKSESEPI 301
                 .:|.||.:.|....||...::....|.|..     :..|....:||.||. ...:...|:
Mouse   222 -----PVPPIPPVPSVPPMTTLPPMSGMPPLNPPP-----VAPLPAGMNGSGAPI-GLNNNMNPV 275

  Fly   302 AFASVNPYAQMYPQLFQQQQMLLQQQQTQAKVSPTMGGSPGGGSTPQVVADTCYIRMSGMCQNTS 366
            ....:||...:        ||..|.......::|                |..|:.:.||..:..
Mouse   276 FLGPLNPVNSI--------QMNSQSSVKSLPINP----------------DDLYVSVHGMPFSAM 316

  Fly   367 YSDIRKYFQGMYIPHNGIKIMMVN-GSRTGVAYVEFSRVSSAQKAVQRNNTMFRDRLIQIVPVGD 430
            .:|:|::|.|:.:  :.:.::..: |...|...|:|.......:|::||..:...|.:::.|..:
Mouse   317 ENDVREFFHGLRV--DAVHLLKDHVGRNNGNGLVKFLSPQDTFEALKRNRMLMIQRYVEVSPATE 379

  Fly   431 DEFEMA-----------------------EERASRQGQDGSRSHGNHNGGDRGERGGGAPVPVPR 472
            .::..|                       ....|..||..|||...|..|
Mouse   380 RQWVAAGGHITFKQSMGPSGQAHPPPQTLPRSKSPSGQKRSRSRSPHEAG--------------- 429

  Fly   473 PVTNVLYIEDLPQTTTEQDIMKMFSASYTVVD-ILLSPSPKNRRESVAFVLFAREAEADSALQDT 536
               ..:|::.||.....:.::..|.....|.| |.::..|..:.....||.|..:|:..:|| ..
Mouse   430 ---FCVYLKGLPFEAENKHVIDFFKKLDIVEDSIYIAYGPNGKATGEGFVEFRNDADYKAAL-CR 490

  Fly   537 SKHYIGFRQLRVRSSSEEDMQNAKEKQRRANEQLLKEEADQREELLKDQQRRQKQQQQENENIQA 601
            .|.|:|.|.::|...:::.|   .||.....::|.....||||.:|
Mouse   491 HKQYMGNRFIQVHPITKKGM---LEKIDMIRKRLQNFSYDQRELVL------------------- 533

  Fly   602 NRFAADPRRRQAEDQQQQQQMNMGPNFNSNMSPNMMAPFVNGGNMPFHMP-----------PLQQ 655
                                     |....:|...:...:.  |:||.:.           |:.:
Mouse   534 -------------------------NPEGEVSSAKVCAHIT--NIPFSITKMDVLQFLEGIPVDE 571

  Fly   656 NGVNNFPFNMNNNYNYNGNSNGNGPNYPNDNGGAGVIQRPRQEDVFVRVHNCEYATRANDLGELF 720
            :.|:....|           ||.|.       |..::|...::|    .|..|:..|....|...
Mouse   572 SAVHVLVDN-----------NGQGL-------GQALVQFKTEDD----AHKSEHLHRKKLNGREA 614

  Fly   721 SLEHLRIEHIEQLFNERN-QSSGEFIVEFSDPA--------SCKLAIREFHNRRFRGRGLRVVAI 776
            .:..:.:|.:.::  |:| .:.|:..::.|.|.        |..:...........|.||....:
Mouse   615 FVHIVTLEDMREI--EKNPPAQGKKGLKISVPGNPAVPVIPSAGMPAAGIPTAGIPGAGLPSAGM 677

  Fly   777 T----------------------------------------------PQEIADRMKKPFM--DYL 793
            .                                              |......|..|.|  ..:
Mouse   678 PGAGMPSSGMPGPGMPGPGIPGAGIPGPAMPGPAMPGPAMPGPAMPGPAMPGPAMPGPAMPGPAM 742

  Fly   794 PGGNGPRKAETNNANDGAG--------------GNKASAQ------PSRRRGPSRFDKPQEQP-- 836
            ||...|..|....|..|||              |:|.:..      |....||:.|..|...|
Mouse   743 PGPAIPGPAIPGPAIPGAGIPSAGGEEHVFLTVGSKEANNGPPFNFPGNFGGPNAFGPPLPPPGL 807

  Fly   837 --SQQQDRP------------LSLE-------REDNSSTSSNAPVKQHF--NPFARPDPPLSSSS 878
              :....||            |.||       ..:.|..|....:.|:|  .|.:...||...|
Mouse   808 GGAFGDVRPVMPSVGNSGLPGLGLEVPGFGGAPNNISGPSGFGGIPQNFGNGPGSLNAPPGFGS- 871

  Fly   879 LSPSNQGQV------KPT---SPVPVPTSI-IPDKF----NRPG-CVVAMRNVPFKAELKDIMRF 928
             .|...|.|      .|.   .|.|.|..| .|..|    .:|| .::.::|:||...:.:|:.|
Mouse   872 -GPPGLGSVPGHLSGPPAFGPGPGPGPIHIGGPPGFGASSGKPGPTIIKVQNMPFTVSIDEILDF 935

  Fly   929 FSDYKLSPDDIIRRFNDEGKPTGDTRVAFESPSEARSAFESRRKKQIFNRTVYL 982
            |..|::.|..:..::|::|.|||:..|||||..||.:|......:.|.:|.|.|
Mouse   936 FYGYQVIPGSVCLKYNEKGMPTGEAMVAFESRDEATAAVIDLNDRPIGSRKVKL 989

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7879	NP_647626.1	RRM1_RBM12_like	2..75	CDD:240954	42/72 (58%)
		RRM_hnRNPH_ESRPs_RBM12_like	355..425	CDD:240700	15/70 (21%)
		RRM	<364..551	CDD:223796	41/211 (19%)
		RRM_SF	478..549	CDD:240668	18/71 (25%)
		RRM_SF	702..773	CDD:240668	14/79 (18%)
		RRM_hnRNPH_ESRPs_RBM12_like	910..982	CDD:240700	24/71 (34%)
Rbm12	NP_083673.3	RRM1_RBM12	1..92	CDD:241189	51/90 (57%)
		RRM2_RBM12	303..377	CDD:241191	15/75 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	393..424		6/30 (20%)
		RRM	<401..610	CDD:223796	53/298 (18%)
		RRM3_RBM12	421..521	CDD:240956	26/121 (21%)
		RRM4_RBM12	545..632	CDD:241193	19/112 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	849..913		16/65 (25%)
		RRM5_RBM12	915..989	CDD:241195	24/73 (33%)
		RRM	<915..>988	CDD:223796	23/72 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	212	1.000	Inparanoid score	I3636
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001433
OrthoInspector	1	1.000	-	-		otm42960
orthoMCL	1	0.900	-	-		OOG6_112833
Panther	1	1.100	-	-	O	PTHR13976
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R11245
SonicParanoid	1	1.000	-	-		X6068
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.940