DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7879 and Rbm12b1

DIOPT Version :9

Sequence 1:	NP_647626.1	Gene:	CG7879 / 38184	FlyBaseID:	FBgn0035235	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	NP_082502.2	Gene:	Rbm12b1 / 72397	MGIID:	1919647	Length:	836	Species:	Mus musculus

Alignment Length:	1071	Identity:	234/1071 - (21%)
Similarity:	371/1071 - (34%)	Gaps:	321/1071 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSVIIRLQNLPWTANARDIRNFFSGLSIPEGGVHIIGGEMGDAFIAFSTDEDARCAMLKDREKLM 65
            |:|:|||..||:.|...|||:||.||:||:||||||||::|:|||.|:||||||.|:.:....:.
Mouse     1 MAVVIRLLGLPFIAGPVDIRHFFKGLTIPDGGVHIIGGKVGEAFIIFATDEDARRAISRSGGFIK 65

  Fly    66 EIQVRLLLSSRAEMQKVIETARKAASAQAPVSVPVPMPVVVPVTAAKVAGPAAPLPPIIGGLNTF 130
            :..|.|.|||:.||||.||..|.|.                       .|...|
Mouse    66 DSSVELFLSSKVEMQKTIEMKRTAR-----------------------VGRGRP----------- 96

  Fly   131 LGQGQVKGVATGTVPSFLTYQQQAGITLSD-VTGRRSRSRSSSSDDSDRERERDRQRERERGRKR 194
             |.| ..||  |.|..|           || :....|.|...||.:.|.....:......|.||.
Mouse    97 -GSG-ASGV--GNVYHF-----------SDALKEEESYSGYGSSVNRDAGFHTNGTGLDLRPRKT 146

  Fly   195 RSDRLDKS-----------QERELKMVAGGGALPSPWAQPPQNQLPAVGL-------GLNMGLNL 241
            |..:.:..           .|.::::...|              |...|:       |.|.|
Mouse   147 RPLKAENPYLFLRGLPYLVNEDDVRVFFSG--------------LCVDGVILLKHHDGRNNG--- 194

  Fly   242 NLPQIPSLQSYTTSTTTTNVTNNYNLEPSATSVQLLTALQQ--------VSSGSAAPAQPSKSES 298
                 .::..:.:....:.....:.....:..::::...:|        .:.|...|...|:..|
Mouse   195 -----DAIVKFASCVDASGGLKCHRSFMGSRFIEVMQGSEQQWIEFGGTATEGGDTPRMRSEEHS 254

  Fly   299 EPIAFASVNPYAQMYPQLFQQQQMLLQQQQTQAKVSPTMGGSPGGGSTPQVVADTCYIRMSGMCQ 363
                     |..::..:.|        ::::.:|.......||.|          .|:.:..:..
Mouse   255 ---------PSRRINGRHF--------RKRSHSKSPRARSRSPLG----------FYVHLKNLSL 292

  Fly   364 NTSYSDIRKYFQGMYIPHNGIKIMMVNGSRTGVAYVEFSRVSSAQKAVQRNNTMFRDRLIQIVPV 428
            ||:..|:|..|:...:.::.||.:..:..||..|:|.|........|:..:.|:.:.|.:.|.||
Mouse   293 NTNKRDLRNLFRDTDLTNDQIKFVYKDERRTRYAFVMFKNQKDYNTALGLHKTVLQYRPVLIDPV 357

  Fly   429 GDDEF-------------EMAEERASRQGQDGSRSHGNHNGGDRGERGGGAPVPVPRPVTNVLYI 480
            ...|.             .:.:||..|..|..|:         .|..|.|..:        .:||
Mouse   358 SRKEMVRIIECYEKKRPESLEKERPGRVSQKYSQ---------EGFSGSGQKL--------CIYI 405

  Fly   481 EDLPQTTTEQDIMKMFSASYTVV--DILLSPSPKNRRESVAFVLFAREAEADSALQDTSKHYIGF 543
            .:||...|:.::.|.| |.:::|  ||.|....|......|.|.|..|.:|..|.:...:.::|.
Mouse   406 RNLPFDVTKGEVQKFF-ADFSLVEDDIYLLCDDKGVGLGEALVRFKSEEQAMKAERLNRQRFLGI 469

  Fly   544 RQLRVRSSSEEDMQNAKEKQRRANEQLLKEEADQREELLKDQQRRQKQQQQENENIQANRFAADP 608
            ..| :|..|||.||                |...:...|.:::.:...:..:.::........||
Mouse   470 EVL-LRLISEEQMQ----------------EFGVKSSWLSNERTQACSRSHDGDDCSCLFDLKDP 517

  Fly   609 RRRQAEDQQQQQQMNMGPNFNSNMSPNMMAPFVNGGNMPFHMPPLQQNGVNNFPFNMNNNYNYNG 673
                                 |:.|      |....::.:|...|::.|      :..:...|..
Mouse   518 ---------------------SSCS------FGQSESLRYHPKDLRKMG------HFKHPQGYFR 549

  Fly   674 NSNGNGP----NYPNDNGGAGVIQRP----------------------RQEDVFVRVHNCEYATR 712
            .|:...|    :.|.|      .:.|                      .|||.|.:.|..:....
Mouse   550 QSDRRSPEDFRHSPED------YRHPWEEHTSHSREEDWRLPLEDWKWSQEDDFRQCHEKDRRQL 608

  Fly   713 ANDLGELF---SLEHLR---IEHIEQLFNERNQSSGEFIVEFSDPASCKLAIREFHNRRFRGRGL 771
            .:...|.|   |.||.|   .|||.|                  |.       |.|.||.|....
Mouse   609 RSPWEEDFRRPSQEHFRRSYQEHIRQ------------------PP-------EEHFRRSREEDF 648

  Fly   772 RVVAITP-QEIAD---RMKKPFMDYLPGGNGPRKAETNNANDGAGGNKASAQPSR-RRGPSRFDK 831
            |.||... ::.:|   |..:..:.| |.....|:....:..:         .|.: .|.|..|..
Mouse   649 RHVADEDFRQASDEDFRTSQEDLRY-PTDEDFRRVSVEDLRE---------VPEKDLRLPKNFRS 703

  Fly   832 PQEQ----PSQQQDRPLSLEREDNSSTSSNAPVKQHFNPFARPDPPLSSSSLSPSNQGQVKPTSP 892
            |.|:    |..:...|..  ..|:.........|..|..|  ||               .|.||.
Mouse   704 PGEEFWTPPDFRGQHPFG--NFDHLQGGKFDFEKYKFGSF--PD---------------AKVTSD 749

  Fly   893 VP---VPTSIIPDKFNRPGCVVAMRNVPFKAELKDIMRFFSDYKLSPDDIIRRFNDEGKPTGDTR 954
            :.   |...|||         |.:.|:||||...:|:.||..||:.||.:..::|::|.|.|:..
Mouse   750 LNLNCVSDKIIP---------VKISNLPFKANASEILDFFHGYKVIPDSVSLQYNEQGLPIGEAI 805

  Fly   955 VAFESPSEARSAFESRRKKQIFNRTVYLDII 985
            ||..:.:||.:|.:....:.:..|.|.|.::
Mouse   806 VAMTNYNEALAAVKDLSGRPVGPRKVKLSLL 836

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7879	NP_647626.1	RRM1_RBM12_like	2..75	CDD:240954	39/72 (54%)
		RRM_hnRNPH_ESRPs_RBM12_like	355..425	CDD:240700	16/69 (23%)
		RRM	<364..551	CDD:223796	49/201 (24%)
		RRM_SF	478..549	CDD:240668	21/72 (29%)
		RRM_SF	702..773	CDD:240668	17/76 (22%)
		RRM_hnRNPH_ESRPs_RBM12_like	910..982	CDD:240700	24/71 (34%)
Rbm12b1	NP_082502.2	RRM_SF	2..80	CDD:418427	42/77 (55%)
		RRM2_RBM12B	152..237	CDD:410140	8/106 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	237..277		7/56 (13%)
		RRM_SF	283..362	CDD:418427	19/78 (24%)
		RRM	<367..559	CDD:223796	48/259 (19%)
		RRM4_RBM12B	401..476	CDD:410142	22/84 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	539..572		7/44 (16%)
		PTZ00465	<601..708	CDD:185644	31/141 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	620..644		13/48 (27%)
		RRM_SF	760..836	CDD:418427	27/84 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	212	1.000	Inparanoid score	I3636
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132643at33208
OrthoFinder	1	1.000	-	-		FOG0001433
OrthoInspector	1	1.000	-	-		otm42960
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13976
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R11245
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	8.050