Protein Alignment CG7879 and Rbm12

DIOPT Version :10

• Sequence 1: NP_647626.1
• Gene: CG7879 / 38184
• FlyBaseID: FBgn0035235
• Length: 985
• Species: Drosophila melanogaster
• Sequence 2: NP_001032746.1
• Gene: Rbm12 / 652928
• RGDID: 1594333
• Length: 1032
• Species: Rattus norvegicus
• Alignment Length: 1222
• Identity: 246/1222 - (20%)
• Similarity: 389/1222 - (31%)
• Gaps: 433/1222 - (35%)

  Fly     1 MSVIIRLQNLPWTANARDIRNFFSGLSIPEGGVHIIGGEMGDAFIAFSTDEDARCAMLKDREKLM 65
            |:|:||||.||..|...|||:|||||:||:|||||:|||:|:|||.|:||||||..|::....:.
  Rat     1 MAVVIRLQGLPIVAGTMDIRHFFSGLTIPDGGVHIVGGELGEAFIVFATDEDARLGMMRTGGTIK 65

  Fly    66 EIQVRLLLSSRAEMQKVIETARKAASAQAPVSVPVPMPVVVPVTAAKVAGPAAPLPPIIGGLNTF 130
            ..:|.|||||:.|||.:||.:|:.... |.:.:|       |..|::..      ||...|:::.
  Rat    66 GSKVTLLLSSKTEMQNMIELSRRRFET-ANLDIP-------PANASRSG------PPPSSGMSSR 116

  Fly   131 LGQGQVKGVATGTVPSFLTYQQQAGITLSDVTGRRSRSRSSSSDDSDRERERDRQRERERGRKRR 195
            :.       ...|||||   ...:...::..|.....::|..:..:..............|....
  Rat   117 VN-------LPATVPSF---NNPSPSVVTATTSVHESNKSIQTFSTASVGTAPPSMGTSFGSPTF 171

  Fly   196 SDRLDKSQE----------------RELKMVAGGGALPSPWAQPPQNQLPAVGLGLNMGLNLNLP 244
            |..:..:..                ..|..:.....:|.|   ||...||.|.         .:|
  Rat   172 SSTIPSTASPMNTVPPPPIPPIPSMPSLPPLPSIPPIPVP---PPVPTLPPVP---------PVP 224

  Fly   245 QIPSLQSYTTSTTTTNVTNNYNLEPSATSVQLLTALQQVSSGSAAPAQPSKSESEPIAFASVNPY 309
            .||.:.|....||...::....|.|...: .|.|.:    :||.||.. ..:...|:....:||
  Rat   225 PIPPVPSVPPMTTLPPISGMPPLNPPPVA-PLPTGM----NGSGAPIS-LNNNLNPVFLGPLNP- 282

  Fly   310 AQMYPQLFQQQQMLLQQQQTQAKVSPTMGGSPGGGSTPQVVADTCYIRMSGMCQNTSYSDIRKYF 374
                                   |:|....|.....:..:..|..|:.:.||..:...:|:|::|
  Rat   283 -----------------------VNPIQMNSQSSVKSLPINPDDLYVSVHGMPFSAMENDVREFF 324

  Fly   375 QGMYIPHNGIKIMMVN-GSRTGVAYVEFSRVSSAQKAVQRNNTMFRDRLIQIVPVGDDEFEMA-- 436
            .|:.:  :.:.::..: |...|...|:|.......:|::||..:...|.:::.|..:.::..|
  Rat   325 HGLRV--DAVHLLKDHVGRNNGNGLVKFLSPQDTFEALKRNRMLMIQRYVEVSPATERQWVAAGG 387

  Fly   437 ---------------------EERASRQGQDGSRSHGNHNGGDRGERGGGAPVPVPRPVTNVLYI 480
                                 ....|..||..|||...|..|                  ..:|:
  Rat   388 HITFKQSMGPSGQAHPPPQTLPRSKSPSGQKRSRSRSPHEAG------------------FCVYL 434

  Fly   481 EDLPQTTTEQDIMKMFSASYTVVD-ILLSPSPKNRRESVAFVLFAREAEADSALQDTSKHYIGFR 544
            :.||.....:.::..|.....|.| |.::..|..:.....||.|..:|:..:|| ...|.|:|.|
  Rat   435 KGLPFEAENKHVIDFFKKLDIVEDSIYIAYGPNGKATGEGFVEFRNDADYKAAL-CRHKQYMGNR 498

  Fly   545 QLRVRSSSEEDMQNAKEKQRRANEQLLKEEADQREELLKDQQRRQKQQQQENENIQANRFAADPR 609
            .::|...:::.|   .||.....::|.....||||.:|
  Rat   499 FIQVHPITKKGM---LEKIDMIRKRLQNFSYDQREMVL--------------------------- 533

  Fly   610 RRQAEDQQQQQQMNMGPNFNSNMSPNMMAPFVNGGNMPFHMP-----------PLQQNGVNNFPF 663
                             |....:|...:...:.  |:||.:.           |:.:|.|:....
  Rat   534 -----------------NPEGEVSSAKVCAHIT--NIPFSITKMDVLQFLEGIPVDENAVHVLVD 579

  Fly   664 NMNNNYNYNGNSNGNGPNYPNDNGGAGVIQRPRQEDVFVRVHNCEYATRANDLG-ELFSLEHLRI 727
            |           ||.|.       |..::|...::|    .|..|:..|....| |.|
  Rat   580 N-----------NGQGL-------GQALVQFKTEDD----AHKSEHLHRKKLNGREAF------- 615

  Fly   728 EHIEQLFNERNQSSGEFIVEFSDPASCKLAIREFHNRRFRGRGLRV-------VAITPQEIADRM 785
            .||..|.:.|.       :|.:.||..|             :||::       |.:.|.......
  Rat   616 VHIVTLEDMRE-------IEKNPPAQGK-------------KGLKIPVPGNPAVPVIPSAGMPAA 660

  Fly   786 KKPFMDY-----------------------------LPGGNGPRKAETNNANDGAG--------- 812
            ..|....                             |||...|......:...|.|
  Rat   661 GIPSAGIPSAGIPSAGMPSAGMPSAGLPAAGLPAAGLPGSGMPGSGMPGSGIPGPGIPGPGIPGP 725

  Fly   813 GNKASAQPS--------------------------RRRGPSRFDKPQEQPSQQQDRPL------- 844
            |......|.                          ...|||       .|......|.
  Rat   726 GIPGPGMPGPGIPGPGIPGPGIPGAGIPGPPMPGPAMPGPS-------MPGPAMPGPAMPGPAMP 783

  Fly   845 --------------------SLEREDN------SSTSSNAPVKQHFNPFARPD---PPLSSSSLS 880
                                |...|::      |..::|.|.......|..|:   |||....|.
  Rat   784 GPAIPGPALPGPAIPGPGIPSAGGEEHVFLTVGSKEANNGPPFNFPGNFGGPNAFGPPLPPPGLG 848

  Fly   881 PSNQGQVKPTSP-------------VP----VPTSI--------IPDKF-NRPG----------- 908
            .: .|.|:|..|             ||    .|.:|        ||..| |.||
  Rat   849 GA-FGDVRPVMPSVGNSGLPGLGLEVPGFGGAPNNISGPSGFGGIPQNFGNGPGSLNAPPGFGNG 912

  Fly   909 -------------------------------------------CVVAMRNVPFKAELKDIMRFFS 930
                                                       .::.::|:||...:.:|:.||.
  Rat   913 PPGLGSVPSHLSGPPAFGPGPGPGPIHIGGPPGFGASSGKPGPTIIKVQNMPFTVSIDEILDFFY 977

  Fly   931 DYKLSPDDIIRRFNDEGKPTGDTRVAFESPSEARSAFESRRKKQIFNRTVYL 982
            .|::.|..:..::|::|.|||:..|||||..||.:|......:.|.:|.|.|
  Rat   978 GYQVIPGSVCLKYNEKGMPTGEAMVAFESRDEATAAVIDLNDRPIGSRKVKL 1029

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7879	NP_647626.1	RRM1_RBM12_like	2..75	CDD:409932	42/72 (58%)
		RRM_hnRNPH_ESRPs_RBM12_like	355..425	CDD:409699	15/70 (21%)
		RRM_SF	478..549	CDD:409669	18/71 (25%)
		RRM_SF	700..773	CDD:409669	16/73 (22%)
		RRM5_RBM12_like	909..983	CDD:409937	25/74 (34%)
Rbm12	NP_001032746.1	PHA03377	<642..>701	CDD:177614	6/58 (10%)
		PRK15313	<770..>822	CDD:237940	4/51 (8%)
		RRM5_RBM12	955..1030	CDD:410145	25/75 (33%)
		RRM1_RBM12	1..92	CDD:241189	51/90 (57%)
		RRM2_RBM12	303..377	CDD:410141	15/75 (20%)
		RRM3_RBM12	421..521	CDD:409934	26/121 (21%)
		RRM4_RBM12	545..632	CDD:410143	24/124 (19%)