DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7879 and Hnrnpf

DIOPT Version :9

Sequence 1:	NP_647626.1	Gene:	CG7879 / 38184	FlyBaseID:	FBgn0035235	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	NP_001032362.1	Gene:	Hnrnpf / 64200	RGDID:	620366	Length:	415	Species:	Rattus norvegicus

Alignment Length:	461	Identity:	89/461 - (19%)
Similarity:	159/461 - (34%)	Gaps:	152/461 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IIRLQNLPWTANARDIRNFFSGLSIPEG--GVHII----GGEMGDAFIAFSTDEDARCAMLKDRE 62
            :::|:.|||:.:..|::||.|..:|.:|  |||.|    |.:.|:||:...:::|.:.|:.||||
  Rat    12 VVKLRGLPWSCSIEDVQNFLSDCTIHDGVAGVHFIYTREGRQSGEAFVELESEDDVKLALKKDRE 76

  Fly    63 KLMEIQVRLLLSSRAEMQKVIETA--RKAASAQAPVSVPVPMPV---------------VVPVTA 110
            .:....:.:..|.|.||..|::.:  ..|.||.........:|.               :||
  Rat    77 SMGHRYIEVFKSHRTEMDWVLKHSGPNSADSANDGFVRLRGLPFGCTKEEIVQFFSGLEIVP--- 138

  Fly   111 AKVAGPAAPLPPIIGGLNTFLGQGQVKGVATGTVPSFLTYQQQAGITLSDVTGRRSRSRSSSSDD 175
               .|...|:.|          :|::.|.|      |:.:..|
  Rat   139 ---NGITLPVDP----------EGKITGEA------FVQFASQ---------------------- 162

  Fly   176 SDRERERDRQRERERGRKRRSDRLDKSQER-------ELKMVAGGGALPSPWAQPPQNQLPAVGL 233
              ...|:...:.:||...|..:....|||.       .||.::  ...|.|:.:|...: ..:|:
  Rat   163 --ELAEKALGKHKERIGHRYIEVFKSSQEEVRSYSDPPLKFMS--VQRPGPYDRPGTAR-RYIGI 222

  Fly   234 GLNMGLNLNLPQIPSLQS------YTTSTTTTNVTNNYNLEPSATSVQLLTALQQVSSGSAAPAQ 292
            ....||:       .::|      |......:.:::.|..........|...|    ||
  Rat   223 VKQAGLD-------RMRSGAYSAGYGGYEEYSGLSDGYGFTTDLFGRDLSYCL----SG------ 270

  Fly   293 PSKSESEPIAFASVNPYAQMYPQLFQQQQMLLQQQQTQAKVSPTMGGSPGGGSTPQVVADTCYIR 357
                               ||...:...:..:|.         |.|              .| :.
  Rat   271 -------------------MYDHRYGDSEFTVQS---------TTG--------------HC-VH 292

  Fly   358 MSGMCQNTSYSDIRKYFQGMYIPHNGIKIMM---VNGSRTGVAYVEFSRVSSAQKAVQRNNTMFR 419
            |.|:....:.:||..:|.    |.|.:::.:   .:|..||.|.|||:....|..|:.::....:
  Rat   293 MRGLPYKATENDIYNFFS----PLNPVRVHIEIGPDGRVTGEADVEFATHEEAVAAMSKDRANMQ 353

  Fly   420 DRLIQI 425
            .|.|::
  Rat   354 HRYIEL 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7879	NP_647626.1	RRM1_RBM12_like	2..75	CDD:240954	24/76 (32%)
		RRM_hnRNPH_ESRPs_RBM12_like	355..425	CDD:240700	18/72 (25%)
		RRM	<364..551	CDD:223796	16/65 (25%)
		RRM_SF	478..549	CDD:240668
		RRM_SF	702..773	CDD:240668
		RRM_hnRNPH_ESRPs_RBM12_like	910..982	CDD:240700
Hnrnpf	NP_001032362.1	RRM1_hnRNPH_hnRNPH2_hnRNPF	10..88	CDD:410128	24/75 (32%)
		Interaction with RNA. /evidence=ECO:0000250	81..86		0/4 (0%)
		RRM2_hnRNPH_hnRNPH2_hnRNPF	103..192	CDD:410130	21/134 (16%)
		Interaction with RNA. /evidence=ECO:0000250	179..184		1/4 (25%)
		zf-RNPHF	255..290	CDD:369688	9/86 (10%)
		RRM3_hnRNPH_CRSF1_like	289..363	CDD:409929	19/76 (25%)
		Interaction with RNA. /evidence=ECO:0000250	355..360		2/5 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910