DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7879 and hnrnph1

DIOPT Version :9

Sequence 1:	NP_647626.1	Gene:	CG7879 / 38184	FlyBaseID:	FBgn0035235	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	NP_991247.1	Gene:	hnrnph1 / 402984	ZFINID:	ZDB-GENE-040426-1856	Length:	403	Species:	Danio rerio

Alignment Length:	431	Identity:	93/431 - (21%)
Similarity:	157/431 - (36%)	Gaps:	118/431 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IIRLQNLPWTANARDIRNFFSGLSIPEGG--VHII----GGEMGDAFIAFSTDEDARCAMLKDRE 62
            ::|::.|||:.:..:::.|||...|...|  :|..    |...|:||:.|.::||.:.|:.||||
Zfish     8 VVRVRGLPWSCSVDEVQRFFSECKIASNGTSIHFTYTREGRPSGEAFVEFESEEDLKIAVKKDRE 72

  Fly    63 KLMEIQVRLLLSSRAEMQKVIETARKAASAQAPVSVPVPMPVVVPVTAAKVAGPAAPLPPIIGGL 127
            .:....|.:..|:..||..|:                            |..||..   |..||.
Zfish    73 TMGHRYVEVFKSNSVEMDWVL----------------------------KHTGPNC---PETGGD 106

  Fly   128 NTFLGQGQVKGVATGTVPSFLTYQQ--QAGITLS-DVTGRRSRS---RSSSSDDSDRERERDRQR 186
            .....:|...|.:...:..|....:  ..||||. |..||.:..   :.:|.|.:::..::.::|
Zfish   107 GLVRLRGLPFGCSKEEIVQFFAGLEIVPNGITLPVDFQGRSTGEAFVQFASQDIAEKALKKHKER 171

  Fly   187 ERERGRK-RRSDRLDKSQERELKMVAGGGALPSPWAQPPQNQLPAVGLGLN-MGLNLNLPQI--- 246
            ...|..: .:|.|.:.....|.:....|...|||:.:      |..|.|.| ||..::..::
Zfish   172 IGHRYIEIFKSSRAEVRTHYEPQRKVMGMQRPSPYDR------PGGGRGYNSMGRGVSFERMRRG 230

  Fly   247 ------------PSLQSYT----------TSTTTTNVTNNYN-LEPSATSVQL-----LTALQQV 283
                        .|.||.|          ...|.|::.|.:: |.|....:::     :|....|
Zfish   231 GYGGDGRYGDSGSSFQSTTGHCVHMRGLPYRATETDIYNFFSPLNPVRVHLEIGPDGRVTGEADV 295

  Fly   284 SSGSAAPAQPSKSESEPIAFASVNPYAQM---YPQLFQQQ-----------QML--LQQQQTQAK 332
            ...:...|..:.|:.:          |.|   |.:||...           ||:  :..|.:...
Zfish   296 EFATHEDAVAAMSKDK----------ANMQHRYVELFLNSTAGGGSGGYGGQMMGGMGNQSSYGH 350

  Fly   333 VSPTMGGSPGGGSTPQVVADTCYIRMSGMCQNTSYSDIRKY 373
            .|..||...|||          |...|||...:.||:.:.:
Zfish   351 SSQQMGSGYGGG----------YANQSGMGGYSDYSECQLF 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7879	NP_647626.1	RRM1_RBM12_like	2..75	CDD:240954	23/76 (30%)
		RRM_hnRNPH_ESRPs_RBM12_like	355..425	CDD:240700	6/19 (32%)
		RRM	<364..551	CDD:223796	2/10 (20%)
		RRM_SF	478..549	CDD:240668
		RRM_SF	702..773	CDD:240668
		RRM_hnRNPH_ESRPs_RBM12_like	910..982	CDD:240700
hnrnph1	NP_991247.1	RRM	<5..>74	CDD:223796	22/65 (34%)
		RRM1_hnRNPH_hnRNPH2_hnRNPF	6..84	CDD:241173	23/75 (31%)
		RRM	<57..>168	CDD:223796	31/141 (22%)
		RRM_SF	89..184	CDD:302621	23/125 (18%)
		RRM3_hnRNPH_hnRNPH2_hnRNPF	251..326	CDD:241178	14/84 (17%)
		RRM	<251..>307	CDD:223796	8/55 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910