DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7879 and RBM12B

DIOPT Version :9

Sequence 1:	NP_647626.1	Gene:	CG7879 / 38184	FlyBaseID:	FBgn0035235	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	NP_001364889.1	Gene:	RBM12B / 389677	HGNCID:	32310	Length:	1001	Species:	Homo sapiens

Alignment Length:	1163	Identity:	235/1163 - (20%)
Similarity:	392/1163 - (33%)	Gaps:	340/1163 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSVIIRLQNLPWTANARDIRNFFSGLSIPEGGVHIIGGEMGDAFIAFSTDEDARCAMLKDREKLM 65
            |:|:|||..||:.|...|||:||:||:||:|||||||||:|:|||.|:||||||.|:.:....:.
Human     1 MAVVIRLLGLPFIAGPVDIRHFFTGLTIPDGGVHIIGGEIGEAFIIFATDEDARRAISRSGGFIK 65

  Fly    66 EIQVRLLLSSRAEMQKVIETARKAASAQAPVSVPVPMPVVVPVTAAKVAGPAAPLPPIIGGLNTF 130
            :..|.|.|||:|||||.||..|                                        ...
Human    66 DSSVELFLSSKAEMQKTIEMKR----------------------------------------TDR 90

  Fly   131 LGQGQVKGVATGTVPSFLTYQQQAGITLSDVTGRRSRSRSSSSDDSDRE-RERDRQRERERGRKR 194
            :|:|: .|..|..|.|...:       :..|....|.|...||.:.|.. ..........|.||.
Human    91 VGRGR-PGSGTSGVDSLSNF-------IESVKEEASNSGYGSSINQDAGFHTNGTGHGNLRPRKT 147

  Fly   195 RSDRLDKS-----------QERELKMVAGGGALPSPWAQPPQNQLPAVGL-------GLNMGLNL 241
            |..:.:..           .|.::::...|              |...|:       |.|.|
Human   148 RPLKAENPYLFLRGLPYLVNEDDVRVFFSG--------------LCVDGVIFLKHHDGRNNG--- 195

  Fly   242 NLPQIPSLQSYTTSTTTTNVTNNYNLEPSATSVQLLTALQQ--VSSGSAAPAQPS---KSESEPI 301
                 .::..:.:....:.....:.....:..::::...:|  :..|..|..:..   :||..
Human   196 -----DAIVKFASCVDASGGLKCHRSFMGSRFIEVMQGSEQQWIEFGGNAVKEGDVLRRSEEH-- 253

  Fly   302 AFASVNPYAQMYPQLFQQQQMLLQQQQTQAKVSPTMGGSPGGGSTPQVVADTCYIRMSGMCQNTS 366
                 :|...:..:.|:::......::|:::       ||.|          .|:.:..:..:..
Human   254 -----SPPRGINDRHFRKRSHSKSPRRTRSR-------SPLG----------FYVHLKNLSLSID 296

  Fly   367 YSDIRKYFQGMYIPHNGIKIMMVNGSRTGVAYVEFSRVSSAQKAVQRNNTMFRDRLIQIVPVGDD 431
            ..|:|.:|:|..:....|:.:..:.:||..|:|.|..:.....|:..:.|:.:.|.:.|.|:...
Human   297 ERDLRNFFRGTDLTDEQIRFLYKDENRTRYAFVMFKTLKDYNTALSLHKTVLQYRPVHIDPISRK 361

  Fly   432 E-------FEMAEERASRQGQDGSRSHGNHNGGDRGERGGGAPVPVPRPVTNVLYIEDLPQTTTE 489
            :       :|.....:..:.:.|..|......|:.|::             ..:||.:.|...|:
Human   362 QMLKFIARYEKKRSGSLERDRPGHVSQKYSQEGNSGQK-------------LCIYIRNFPFDVTK 413

  Fly   490 QDIMKMFSASYTVV--DILLSPSPKNRRESVAFVLFAREAEADSALQDTSKHYIG---------- 542
            .::.|.| |.:.:.  ||.|....|......|.|.|..|.:|..|.:...:.::|
Human   414 VEVQKFF-ADFLLAEDDIYLLYDDKGVGLGEALVKFKSEEQAMKAERLNRRRFLGTEVLLRLISE 477

  Fly   543 --FRQLRVRSS--SEEDMQNAKEKQRRANEQLLKEEAD--------------QREEL-----LKD 584
              .::..|..|  |.|.||...:.:.|.:...|.:..|              |.|:|     .|.
Human   478 AQIQEFGVNFSVMSSEKMQARSQSRERGDHSHLFDSKDPPIYSVGAFENFRHQLEDLRQLDNFKH 542

  Fly   585 QQRRQKQ----------QQQENENIQANRFAADP---RRRQAEDQQQ----------QQQMNMGP 626
            .||..:|          ...|:.......|...|   ||.:.||.::          ::.....|
Human   543 PQRDFRQPDRHPPEDFRHSSEDFRFPPEDFRHSPEDFRRPREEDFRRPSEEDFRRPWEEDFRRPP 607

  Fly   627 --NFNSNMSPNMMAPFVNGGNMP--------------------FHMPP------LQQNGVNNFP- 662
              :|......:...|.......|                    |..||      |.:......|
Human   608 EDDFRHPREEDWRRPLEEDWRRPLEEDFRRSPTEDFRQLPEEDFRQPPEEDLRWLPEEDFRRPPE 672

  Fly   663 --FNMNNNYNYNGNSNGNGPNYPNDNGGAGVIQRPRQEDVFVRVHNCEYATRANDLGELF---SL 722
              :......::.....|.....|.|:     .:||.:||.   .|:.|...|.:. .|.|   ..
Human   673 EDWRRPPEEDFRRPLQGEWRRPPEDD-----FRRPPEEDF---RHSPEEDFRQSP-QEHFRRPPQ 728

  Fly   723 EHLR---IEHIEQLFNERNQSSGEFIVEFSDPASCKLAIREFHNRR-----FRGRGLRVVAITPQ 779
            ||.|   .||..:...|..:...........|...:....| |.||     ||..........||
Human   729 EHFRRPPPEHFRRPPPEHFRRPPPEHFRRPPPEHFRRPPPE-HFRRPPPEHFRRPPQEHFRRPPQ 792

  Fly   780 EIADRMKKPFMDYLPGGN--GPRKAETNNANDGAGGNKASAQPSRRRGPSRFDKPQEQ----PSQ 838
            |...|.::....:.|..:  ||...:..:..|                 ..|..|||:    ||.
Human   793 EHFRRSREEDFRHPPDEDFRGPPDEDFRHPPD-----------------EDFRSPQEEDFRCPSD 840

  Fly   839 QQDRPLSLE------REDNSSTSSNAPVKQHF----------NPFAR------------------ 869
            :..|.|..|      .||.....:..|..:.|          .||..
Human   841 EDFRQLPEEDLREAPEEDPRLPDNFRPPGEDFRSPPDDFRSHRPFVNFGRPEGGKFDFGKHNMGS 905

  Fly   870 -------PDPPLSSSSLSPSNQGQVKPTSPVPVPTSIIPDKFNRPGCVVAMRNVPFKAELKDIMR 927
                   |||.::..|      |:|.|                     :.:.|:||||.:.:|:.
Human   906 FPEGRFMPDPKINCGS------GRVTP---------------------IKIMNLPFKANVNEILD 943

  Fly   928 FFSDYKLSPDDIIRRFNDEGKPTGDTRVAFESPSEARSAFESRRKKQIFNRTVYLDII 985
            ||..|::.||.:..::|::|.|||:..||..:.:||.:|.:....:.:..|.|.|.::
Human   944 FFHGYRIIPDSVSIQYNEQGLPTGEAIVAMINYNEAMAAIKDLNDRPVGPRKVKLTLL 1001

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7879	NP_647626.1	RRM1_RBM12_like	2..75	CDD:240954	40/72 (56%)
		RRM_hnRNPH_ESRPs_RBM12_like	355..425	CDD:240700	14/69 (20%)
		RRM	<364..551	CDD:223796	39/207 (19%)
		RRM_SF	478..549	CDD:240668	18/84 (21%)
		RRM_SF	702..773	CDD:240668	18/81 (22%)
		RRM_hnRNPH_ESRPs_RBM12_like	910..982	CDD:240700	23/71 (32%)
RBM12B	NP_001364889.1	RRM1_RBM12B	2..80	CDD:410139	44/77 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	119..147		6/27 (22%)
		RRM2_RBM12B	153..238	CDD:410140	8/106 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	247..278		5/37 (14%)
		RRM3_RBM12B	284..363	CDD:409935	16/78 (21%)
		RRM4_RBM12B	400..475	CDD:410142	18/75 (24%)
		PTZ00121	<449..680	CDD:173412	36/230 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	544..587		9/42 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	631..882		51/277 (18%)
		PHA03321	<689..915	CDD:223041	49/252 (19%)
		RRM5_RBM12B	925..1001	CDD:410144	25/96 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	200	1.000	Inparanoid score	I3782
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132643at33208
OrthoFinder	1	1.000	-	-		FOG0001433
OrthoInspector	1	1.000	-	-		otm40887
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13976
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R11245
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	8.050