DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7879 and RBM12

DIOPT Version :9

Sequence 1:	NP_647626.1	Gene:	CG7879 / 38184	FlyBaseID:	FBgn0035235	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	NP_001185767.1	Gene:	RBM12 / 10137	HGNCID:	9898	Length:	932	Species:	Homo sapiens

Alignment Length:	1133	Identity:	239/1133 - (21%)
Similarity:	386/1133 - (34%)	Gaps:	355/1133 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSVIIRLQNLPWTANARDIRNFFSGLSIPEGGVHIIGGEMGDAFIAFSTDEDARCAMLKDREKLM 65
            |:|:||||.||..|...|||:|||||:||:|||||:|||:|:|||.|:||||||..|::....:.
Human     1 MAVVIRLQGLPIVAGTMDIRHFFSGLTIPDGGVHIVGGELGEAFIVFATDEDARLGMMRTGGTIK 65

  Fly    66 EIQVRLLLSSRAEMQKVIETARK-------------AASAQAPVSVPVPMPVVVPVTAAKVAGPA 117
            ..:|.|||||:.|||.:||.:|:             |:.:..|.|..:...|.:|.|.:....|:
Human    66 GSKVTLLLSSKTEMQNMIELSRRRFETANLDIPPANASRSGPPPSSGMSSRVNLPTTVSNFNNPS 130

  Fly   118 APLPPIIGGLNTFLGQGQVKGVATGTVPSFLTYQQQAGITLSDVTGRRSRSRSSSSDDSDRERER 182
                |.:....|.:.:.. |.:.|.:..|..|.....|.:....|...:...::|.
Human   131 ----PSVVTATTSVHESN-KNIQTFSTASVGTAPPNMGASFGSPTFSSTVPSTASP--------- 181

  Fly   183 DRQRERERGRKRRSDRLDKSQERELKMVAGGGALPSPW-------AQPPQNQLPAVGLGLNMGLN 240
                            ::......:..:....:|| |.       ..||...||.|.
Human   182 ----------------MNTVPPPPIPPIPAMPSLP-PMPSIPPIPVPPPVPTLPPVP-------- 221

  Fly   241 LNLPQIPSLQSYTTSTTTTNVTNNYNLEPSATSVQLLTALQQVSSGSAAPAQPSKSESEPIAFAS 305
             .:|.||.:.|....|....::....|.|..     :..|....:||.||.. ..:...|:....
Human   222 -PVPPIPPVPSVPPMTPLPPMSGMPPLNPPP-----VAPLPAGMNGSGAPMN-LNNNLNPMFLGP 279

  Fly   306 VNPYAQMYPQLFQQQQMLLQQQQTQAKVSPTMGGSPGGGSTPQVVADTCYIRMSGMCQNTSYSDI 370
            :||...:             |..:|:.|.|.           .:..|..|:.:.||..:...:|:
Human   280 LNPVNPI-------------QMNSQSSVKPL-----------PINPDDLYVSVHGMPFSAMENDV 320

  Fly   371 RKYFQGMYIPHNGIKIMMVN-GSRTGVAYVEFSRVSSAQKAVQRNNTMFRDRLIQIVPVGDDEFE 434
            |.:|.|:.:  :.:.::..: |...|...|:|.......:|::||..:...|.:::.|..:.::.
Human   321 RDFFHGLRV--DAVHLLKDHVGRNNGNGLVKFLSPQDTFEALKRNRMLMIQRYVEVSPATERQWV 383

  Fly   435 MA-----------------------EERASRQGQDGSRSHGNHNGGDRGERGGGAPVPVPRPVTN 476
            .|                       ....|..||..|||...|..|                  .
Human   384 AAGGHITFKQNMGPSGQTHPPPQTLPRSKSPSGQKRSRSRSPHEAG------------------F 430

  Fly   477 VLYIEDLPQTTTEQDIMKMFSASYTVVD-ILLSPSPKNRRESVAFVLFAREAEADSALQDTSKHY 540
            .:|::.||.....:.::..|.....|.| |.::..|..:.....||.|..||:..:|| ...|.|
Human   431 CVYLKGLPFEAENKHVIDFFKKLDIVEDSIYIAYGPNGKATGEGFVEFRNEADYKAAL-CRHKQY 494

  Fly   541 IGFRQLRVRSSSEEDMQNAKEKQRRANEQLLKEEADQREELLKDQQRRQKQQQQENENIQANRFA 605
            :|.|.::|...:::.|   .||.....::|.....||||.:|..:
Human   495 MGNRFIQVHPITKKGM---LEKIDMIRKRLQNFSYDQREMILNPE-------------------- 536

  Fly   606 ADPRRRQAEDQQQQQQMNMGPNFNSNMSPNMMAPFVNGGNMPFHMPPLQQNGVNNFPFNMNNNYN 670
            .|                                 ||...:..|        :.|.||::.
Human   537 GD---------------------------------VNSAKVCAH--------ITNIPFSIT---- 556

  Fly   671 YNGNSNGNGPNYPNDNGGAGVIQRPRQEDVFVRVHNCEYATRANDLGELFSLEHLRIEH--IEQL 733
                                      :.||                  |..||.:.::.  :..|
Human   557 --------------------------KMDV------------------LQFLEGIPVDENAVHVL 577

  Fly   734 FNERNQSSGEFIVEFSDPASCKLAIREFHNRRFRGRGLRVVAITPQEIAD-------------RM 785
            .:...|..|:.:|:|.:....:.:.| .|.::..||...|..:|.:::.:             :|
Human   578 VDNNGQGLGQALVQFKNEDDARKSER-LHRKKLNGREAFVHVVTLEDMREIEKNPPAQGKKGLKM 641

  Fly   786 KKPFMDYLPG-----------------GNG------PRKAETNNANDGAG--------------- 812
            ..|....:||                 |.|      |..|.|:....|||
Human   642 PVPGNPAVPGMPNAGLPGVGLPSAGLPGAGLPSTGLPGSAITSAGLPGAGMPSAGIPSAGGEEHA 706

  Fly   813 ----GNKASAQ------PSRRRGPSRFDKPQEQP-----SQQQDRP------------LSLE--- 847
                |:|.:..      |....|.:.|..|...|     :....||            |.|:
Human   707 FLTVGSKEANNGPPFNFPGNFGGSNAFGPPIPPPGLGGGAFGDARPGMPSVGNSGLPGLGLDVPG 771

  Fly   848 ---REDNSSTSS----------NAPVKQHFNP-FARPDPPLSSSS---LSPSNQGQVKPTSPVPV 895
               ..:|.|..|          |.|......| |....|.|.|:.   ..|...|......|.|.
Human   772 FGGGPNNLSGPSGFGGGPQNFGNGPGSLGGPPGFGSGPPGLGSAPGHLGGPPAFGPGPGPGPGPG 836

  Fly   896 PTSI-----IPDKFNRPG-CVVAMRNVPFKAELKDIMRFFSDYKLSPDDIIRRFNDEGKPTGDTR 954
            |..|     ......:|| .|:.::|:||...:.:|:.||..|::.|..:..::|::|.|||:..
Human   837 PIHIGGPPGFASSSGKPGPTVIKVQNMPFTVSIDEILDFFYGYQVIPGSVCLKYNEKGMPTGEAM 901

  Fly   955 VAFESPSEARSAFESRRKKQIFNRTVYL 982
            |||||..||.:|......:.|.:|.|.|
Human   902 VAFESRDEATAAVIDLNDRPIGSRKVKL 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7879	NP_647626.1	RRM1_RBM12_like	2..75	CDD:240954	42/72 (58%)
		RRM_hnRNPH_ESRPs_RBM12_like	355..425	CDD:240700	15/70 (21%)
		RRM	<364..551	CDD:223796	42/211 (20%)
		RRM_SF	478..549	CDD:240668	19/71 (27%)
		RRM_SF	702..773	CDD:240668	12/72 (17%)
		RRM_hnRNPH_ESRPs_RBM12_like	910..982	CDD:240700	25/71 (35%)
RBM12	NP_001185767.1	RRM1_RBM12	1..92	CDD:241189	51/90 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	96..116		3/19 (16%)
		RRM2_RBM12	303..377	CDD:241191	15/75 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	392..424		6/31 (19%)
		RRM3_RBM12	421..521	CDD:240956	27/121 (22%)
		RRM4_RBM12	545..632	CDD:241193	20/143 (14%)
		Sporozoite_P67	<633..>764	CDD:253298	21/130 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	717..853		25/135 (19%)
		RRM5_RBM12	855..929	CDD:241195	25/73 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	200	1.000	Inparanoid score	I3782
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001433
OrthoInspector	1	1.000	-	-		otm40887
orthoMCL	1	0.900	-	-		OOG6_112833
Panther	1	1.100	-	-	O	PTHR13976
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6068
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.910