DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pex10 and Rnf4

DIOPT Version :9

Sequence 1:NP_001261265.1 Gene:Pex10 / 38182 FlyBaseID:FBgn0035233 Length:299 Species:Drosophila melanogaster
Sequence 2:NP_001291198.1 Gene:Rnf4 / 19822 MGIID:1201691 Length:194 Species:Mus musculus


Alignment Length:66 Identity:21/66 - (31%)
Similarity:32/66 - (48%) Gaps:13/66 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   235 STKDVDPNTPQ------CILCLEPRSD-------SSLTPCGHIFCWSCLLEWLEERDECPLCRES 286
            ||||.....|:      |.:|::..|:       ...|.|||:||..||.:.|:..:.||.||:.
Mouse   119 STKDDGATGPRPSGTVSCPICMDGYSEIVQNGRLIVSTECGHVFCSQCLRDSLKNANTCPTCRKK 183

  Fly   287 L 287
            :
Mouse   184 I 184

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pex10NP_001261265.1 Pex2_Pex12 20..>173 CDD:282595
zf-RING_2 244..284 CDD:290367 15/52 (29%)
Rnf4NP_001291198.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..39
Required for ubiquitination activity 1..20
Mediates interaction with TRPS1. /evidence=ECO:0000269|PubMed:12885770 6..65
SUMO interaction motif 1, mediates the binding to polysumoylated substrates. /evidence=ECO:0000250|UniProtKB:P78317 40..43
SUMO interaction motif 2, mediates the binding to polysumoylated substrates. /evidence=ECO:0000250|UniProtKB:P78317 50..53
SUMO interaction motif 3, mediates the binding to polysumoylated substrates. /evidence=ECO:0000250|UniProtKB:P78317 61..63
SUMO interaction motif 4, mediates the binding to polysumoylated substrates. /evidence=ECO:0000250|UniProtKB:P78317 71..74
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 110..130 5/10 (50%)
zf-RING_2 135..181 CDD:290367 14/45 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R146
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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