Protein Alignment Pex10 and RNF145

DIOPT Version :10

• Sequence 1: NP_647624.1
• Gene: Pex10 / 38182
• FlyBaseID: FBgn0035233
• Length: 299
• Species: Drosophila melanogaster
• Sequence 2: NP_001186309.1
• Gene: RNF145 / 153830
• HGNCID: 20853
• Length: 693
• Species: Homo sapiens
• Alignment Length: 182
• Identity: 42/182 - (23%)
• Similarity: 80/182 - (43%)
• Gaps: 36/182 - (19%)

  Fly   135 IIQRLRQSP--------SYVKALHKSLFYLDASKYQLSKRTTGINYVLIRHWLQPEFSLYGYKIL 191
            :::..|:.|        .||...::.|.:|.|    |.....|::..:...|     ::.|..|:
Human   465 MVEEFRKEPVENMDDVIYYVNGTYRLLEFLVA----LCVVAYGVSETIFGEW-----TVMGSMII 520

  Fly   192 GVITFLQVSVSLAISGWDAW--REHKRQQLESIKQAGKNFLQRSSSTKDVDPNTPQCILCLEPRS 254
            .:.::..|.:...: ||.::  |.....:::|:..|.|..|::.:   |:      |.:|.:...
Human   521 FIHSYYNVWLRAQL-GWKSFLLRRDAVNKIKSLPIATKEQLEKHN---DI------CAICYQDMK 575

  Fly   255 DSSLTPCGHIFCWSCLLEWLEERDECPLCRESLKKSQVI-------LLQNYA 299
            .:.:|||.|.|...||.:||..::.||||...||.|..:       :||.:|
Human   576 SAVITPCSHFFHAGCLKKWLYVQETCPLCHCHLKNSSQLPGLGTEPVLQPHA 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pex10	NP_647624.1	Pex2_Pex12	20..>173	CDD:398431	9/45 (20%)
		HRD1	<183..>287	CDD:227568	26/105 (25%)
		RING-HC_PEX10	244..295	CDD:438190	18/57 (32%)
RNF145	NP_001186309.1	TRC8_N	38..536	CDD:463960	13/80 (16%)
		HRD1	<550..>655	CDD:227568	26/87 (30%)
		RING-H2_RNF145	563..605	CDD:319598	15/50 (30%)