DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12099 and RNF10

DIOPT Version :9

Sequence 1:	NP_647623.1	Gene:	CG12099 / 38181	FlyBaseID:	FBgn0035232	Length:	708	Species:	Drosophila melanogaster
Sequence 2:	NP_001317403.1	Gene:	RNF10 / 9921	HGNCID:	10055	Length:	816	Species:	Homo sapiens

Alignment Length:	854	Identity:	264/854 - (30%)
Similarity:	395/854 - (46%)	Gaps:	206/854 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDSNNSSNSKKQPQSSHHG----KSSSA----ESQRKSSELHTNSNKQRHSRRRNQVPTPRND-- 55
            ||.|:.|||......|..|    :|:||    ||:.||...:::.:| |::|:| ::..|:|:
Human    15 MDKNSGSNSSSASSGSSKGQQPPRSASAGPAGESKPKSDGKNSSGSK-RYNRKR-ELSYPKNESF 77

  Fly    56 QQQQPQQPAKLRPNVDKRPKARGFGGGYDFPSPRG---QDGASGSSRLAYSATGYSRSGDFDHEL 117
            ..|..:..::.....:|.|..||.|....|.|...   :|..:.:.|..:|...:|
Human    78 NNQSRRSSSQKSKTFNKMPPQRGGGSSKLFSSSFNGGRRDEVAEAQRAEFSPAQFS--------- 133

  Fly   118 NSVYTQGSKKQNLNHLLNFHCVPRELERGHHHQAQQHHGLSGRKQR-----YNKEQFLQANFQFV 177
                  |.||.||||||||...||. :.||...:  .||..|::.:     :|||.|||||.|||
Human   134 ------GPKKINLNHLLNFTFEPRG-QTGHFEGS--GHGSWGKRNKWGHKPFNKELFLQANCQFV 189

  Fly   178 IRSGAKAQVN-GSPDALIDWSYIEQINIQTTEELQCPICLYPPVAAKLTRCGHAYCWPCLLHYLS 241
            :........: ..||.|::|.::||:.|.:.|...||||||||.|||:|||||.:||.|:|||||
Human   190 VSEDQDYTAHFADPDTLVNWDFVEQVRICSHEVPSCPICLYPPTAAKITRCGHIFCWACILHYLS 254

  Fly   242 LSDKTWRKCPICYDAIHAGDLKSCTIEQLRDLQVGEKITFQLMRRRKG-------SMYIE-NHVA 298
            ||:|||.||||||.::|..||||....:.....||:.||.|||:|.||       |.::. :|..
Human   255 LSEKTWSKCPICYSSVHKKDLKSVVATESHQYVVGDTITMQLMKREKGVLVALPKSKWMNVDHPI 319

  Fly   299 GLGETIERFPFVSAGEEAKRYSKFLIAKRMDV--AAIIERE--RNELLAESDVSCPEDVFIQQAL 359
            .||:           |:..:|||.|:|.:..|  ..::|.:  ..:.||| :...||..||:.|:
Human   320 HLGD-----------EQHSQYSKLLLASKEQVLHRVVLEEKVALEQQLAE-EKHTPESCFIEAAI 372

  Fly   360 VMLQER--------------------VEKLGVEKPDPKED--------------------EEETA 384
            ..|:.|                    :|:|.:..|..||.                    :|||.
Human   373 QELKTREEALSGLAGSRREVTGVVAALEQLVLMAPLAKESVFQPRKSLLQQGVLEYLSAFDEETT 437

  Fly   385 PVLCLET-------------------------ETKIDIEKSDDASISSGEASSSLSYSS------ 418
            .|..|:|                         |...|:|.:|| ::..|...:..|...
Human   438 EVCSLDTPSRPLALPLVEEEEAVSEPEPEGLPEACDDLELADD-NLKEGTICTESSQQEPITKSG 501

  Fly   419 ----NHNKYYYFYQSNDGQNIYLHPLNVKMLQACYGTLDLGPLLIEAQIVQMEQHSMDEEHRRKF 479
                :.:..|||||:.|||:::|||:||:.|...||:|:..|..|.|.:|::..:||.|:.|::.
Human   502 FTRLSSSPCYYFYQAEDGQHMFLHPVNVRCLVREYGSLERSPEKISATVVEIAGYSMSEDVRQRH 566

  Fly   480 TCLGHLPLTCQFSVVEVELQPPVVTGGILKLFKEDILHRKKERQRRDREERKREQHINEINDRQM 544
            ..|.||||||:||:.|:.||||||:...|::|.:||..||::||::.||||:||:.|....:::.
Human   567 RYLSHLPLTCEFSICELALQPPVVSKETLEMFSDDIEKRKRQRQKKAREERRRERRIEIEENKKQ 631

  Fly   545 GKLIASAANLDLSSSHEFP-----TCGFEEALPAPS----GSVPMNISNQDPGSRYS-------- 592
            ||.  ...::.|.:..:||     ||..:.||...|    |::.::..::.|||...
Human   632 GKY--PEVHIPLENLQQFPAFNSYTCSSDSALGPTSTEGHGALSISPLSRSPGSHADFLLTPLSP 694

  Fly   593 SVTLGSPKQEMWPTIGS---NSPGGGGAPLDVQVG-----AWGRSAPPPPRAVMVPRTS-DEDFE 648
            :.:.|||..    .:||   :||....|.: ::||     .|.::||......:||... |.|.|
Human   695 TASQGSPSF----CVGSLEEDSPFPSFAQM-LRVGKAKADVWPKTAPKKDENSLVPPAPVDSDGE 754

  Fly   649 ------------QRSVGHWGLGELLVGALDQKKQKVGAAKSNGAAPA------ESKKQKKAKGKK 695
                        |.|.                .|.:.||......||      |.|..||.|.:|
Human   755 SDNSDRVPVPSFQNSF----------------SQAIEAAFMKLDTPATSDPLSEEKGGKKRKKQK 803

  Fly   696 MVPLFATGM 704
            ...||:|.:
Human   804 QKLLFSTSV 812

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12099	NP_647623.1	zf-C3HC4_2	212..253	CDD:290634	32/40 (80%)
RNF10	NP_001317403.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..119		30/105 (29%)
		Interaction with MEOX2. /evidence=ECO:0000269\|PubMed:16335786	101..185		31/101 (31%)
		zf-C3HC4_2	225..266	CDD:290634	32/40 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	658..677		4/18 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	729..766		8/36 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	781..816		11/32 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149881
Domainoid	1	1.000	156	1.000	Domainoid score	I4195
eggNOG	1	0.900	-	-		E1_KOG2164
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40990
Inparanoid	1	1.050	317	1.000	Inparanoid score	I2550
Isobase	1	0.950	-	0	Normalized mean entropy	S5724
OMA	1	1.010	-	-		QHG51969
OrthoDB	1	1.010	-	-		D1373540at2759
OrthoFinder	1	1.000	-	-		FOG0005735
OrthoInspector	1	1.000	-	-		oto91183
orthoMCL	1	0.900	-	-		OOG6_102933
Panther	1	1.100	-	-	LDO	PTHR12983
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1987
SonicParanoid	1	1.000	-	-		X4131
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750