DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12099 and Rnf10

DIOPT Version :9

Sequence 1:	NP_647623.1	Gene:	CG12099 / 38181	FlyBaseID:	FBgn0035232	Length:	708	Species:	Drosophila melanogaster
Sequence 2:	NP_001289377.1	Gene:	Rnf10 / 50849	MGIID:	1859162	Length:	805	Species:	Mus musculus

Alignment Length:	836	Identity:	257/836 - (30%)
Similarity:	388/836 - (46%)	Gaps:	181/836 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDSNNSSNSKKQPQSSHHG----KSSSA----ESQRKSSELHTNSNKQRHSRRRNQVPTPRNDQQ 57
            ||.|:.|||......|..|    :|:||    ||:.||...::|.:|:.:.:|....|...|...
Mouse    15 MDKNSGSNSSSASSGSSKGQQPPRSASAGPAGESKPKSDGKNSNGSKRYNRKREPSYPKNENFSN 79

  Fly    58 QQPQQPAKLRPNVDKRPKARGFGGGYDFPSPRG---QDGASGSSRLAYSATGYSRSGDFDHELNS 119
            |..:..::.....:|.|..||.|....|.|...   :|..:.:.|..:|...:|
Mouse    80 QSRRSNSQKSKTFNKMPPQRGGGSSKPFSSSSNGGRRDEVAEAQRAEFSPAQFS----------- 133

  Fly   120 VYTQGSKKQNLNHLLNFHCVPRELERGHHHQAQQHHGLSGRKQR-----YNKEQFLQANFQFVIR 179
                |.||.||||||||...||. :.||...:  .||..|::.:     :|||.|||||.|||:.
Mouse   134 ----GPKKINLNHLLNFTFEPRG-QAGHFEGS--GHGGWGKRNKWGHKPFNKELFLQANCQFVVS 191

  Fly   180 SGAKAQVN-GSPDALIDWSYIEQINIQTTEELQCPICLYPPVAAKLTRCGHAYCWPCLLHYLSLS 243
            .......: ..||.|::|.::||:.|.:.|...||||||||.|||:|||||.:||.|:|||||||
Mouse   192 EDQDYAAHFADPDTLVNWDFVEQVRICSHEVPSCPICLYPPTAAKITRCGHIFCWACILHYLSLS 256

  Fly   244 DKTWRKCPICYDAIHAGDLKSCTIEQLRDLQVGEKITFQLMRRRKG-------SMYIE-NHVAGL 300
            :|||.||||||.::|..||||....:.|...||:.||.|||:|.||       |.::. :|...|
Mouse   257 EKTWSKCPICYSSVHKKDLKSVVATESRQYAVGDTITMQLMKREKGVLVALPKSKWVNVDHPINL 321

  Fly   301 GETIERFPFVSAGEEAKRYSKFLIAKRMDVA-AIIERERNEL---LAESDVSCPEDVFIQQALVM 361
            |:           |:..:|||.|:|.:..|. .::..|:..|   ||| :...||..||:.|:..
Mouse   322 GD-----------EQLSQYSKLLLASKEQVLHRVVLEEKGALEQQLAE-EKHTPESCFIEAAIQE 374

  Fly   362 LQERVEKL------------------------------------------------------GVE 372
            ::.|.|.|                                                      .::
Mouse   375 VKIREEALSGVAGGGGEVTGVVAALEHLVLMAPLATESAFQPRKQGVLEYLSAFDDEAAQVCSLD 439

  Fly   373 KPDP------KEDEEETAPVLCLETETKIDIEKSDDASISSGEASSSLSYSS----------NHN 421
            .|.|      :|:|..:.|..|      .|.|.:|| |:..|.....:|...          :.:
Mouse   440 PPGPLALPLVEEEEAVSEPEAC------EDAEVADD-SLGEGTVGPEMSQEEPITKPGFTQLSSS 497

  Fly   422 KYYYFYQSNDGQNIYLHPLNVKMLQACYGTLDLGPLLIEAQIVQMEQHSMDEEHRRKFTCLGHLP 486
            ..|||||:.|||:::|||:||:.|...||:|:..|..|.|.:|::..:||.|:.|::...|.|||
Mouse   498 PCYYFYQAEDGQHMFLHPVNVRCLVREYGSLEQSPEKISATVVEIAGYSMSEDVRQRHRYLSHLP 562

  Fly   487 LTCQFSVVEVELQPPVVTGGILKLFKEDILHRKKERQRRDREERKREQHINEINDRQMGKLIASA 551
            |||:||:.|:.||||||:...|::|.:||..||::||::.||||:||:.|....:::.|:.  ..
Mouse   563 LTCEFSICELALQPPVVSKETLEMFSDDIEKRKRQRQKKAREERRRERRIEMEENKRQGRY--PE 625

  Fly   552 ANLDLSSSHEFP-----TCGFEEALPAPS----GSVPMNISNQDPGSRYS--------SVTLGSP 599
            .::.|.:..:||     ||..:.||...|    |::.::..::.|||...        :.:.|||
Mouse   626 VHIPLENLQQFPAFNSYTCPSDSALGPTSTEGHGALSLSPLSRSPGSHADFLLTPLSPTASQGSP 690

  Fly   600 KQEMWPTIGS---NSPGGGGAPLDVQVG-----AWGRSAP-PPPRAVMVPRTSDEDFEQRSVGHW 655
            ..    .:||   :||....|.: ::||     .|.::|| ....:::.|...|.|.|..:
Mouse   691 SF----CVGSLEDDSPFLSFAQM-LRVGKAKADGWPKTAPKKDDNSLVPPAPVDSDGESDN---- 746

  Fly   656 GLGELLVGALDQK-KQKVGAAKSNGAAPA------ESKKQKKAKGKKMVPLFATGM 704
             ...:.|.:.... .|.:.||......||      |.:..||.|.:|...||:|.:
Mouse   747 -SDRVPVPSFQNSFSQAIEAAFMKLDTPATSDPLSEDRGGKKRKRQKQKLLFSTSV 801

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12099	NP_647623.1	zf-C3HC4_2	212..253	CDD:290634	32/40 (80%)
Rnf10	NP_001289377.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..134		32/133 (24%)
		zf-C3HC4_2	225..266	CDD:290634	32/40 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	590..612		12/21 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	647..666		4/18 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	716..805		21/91 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839926
Domainoid	1	1.000	154	1.000	Domainoid score	I4265
eggNOG	1	0.900	-	-		E1_KOG2164
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40990
Inparanoid	1	1.050	319	1.000	Inparanoid score	I2512
Isobase	1	0.950	-	0	Normalized mean entropy	S5724
OMA	1	1.010	-	-		QHG51969
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005735
OrthoInspector	1	1.000	-	-		oto94766
orthoMCL	1	0.900	-	-		OOG6_102933
Panther	1	1.100	-	-	LDO	PTHR12983
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1987
SonicParanoid	1	1.000	-	-		X4131
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740