DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pns and dennd3a

DIOPT Version :9

Sequence 1:	NP_647620.1	Gene:	pns / 38178	FlyBaseID:	FBgn0035229	Length:	1449	Species:	Drosophila melanogaster
Sequence 2:	XP_021323902.1	Gene:	dennd3a / 797970	ZFINID:	ZDB-GENE-091230-6	Length:	1285	Species:	Danio rerio

Alignment Length:	1552	Identity:	278/1552 - (17%)
Similarity:	473/1552 - (30%)	Gaps:	630/1552 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 PGEQSQSQSELNQLKRDADPQFSRFADYFVICGLDLDTGLEPDRFAGDNLHCS--------PLDR 104
            ||:.:....|...|:..|.|..::...    |...:|.|:.| .|:......|        |:..
Zfish    28 PGKDADVLVEAEVLQVHAPPFITKDRS----CNGGVDQGVAP-AFSRVQKRRSFKKKKRERPVST 87

  Fly   105 AYKSKPLAHYPE-NVPWNPFDAHGICMLSLPQGLRFRTQKHCIEPRFHSFATTREDGKRCYGFSL 168
            ...|...:...| :||.| .|...:..|..|.|||...:             :|||.   |.| |
Zfish    88 LSNSSQASESEELSVPQN-IDLIALPQLCFPDGLRITNE-------------SREDS---YHF-L 134

  Fly   169 VFYEEIRNR------NICGAIHTLQSMFITELSNGQQTHSLSRVKQDGPVSRSLPRHFKVAGQAP 227
            ||.:...|:      ..|..:...|...|  .:||.:|:...|
Zfish   135 VFTDVFGNQTHGVVAQYCRPVQFQQDNVI--YANGHRTNEHKR---------------------- 175

  Fly   228 QSAQSYYDINKDKLYVAKSITLICQAPYAFAAQMFLKNLYRCLPRQPGAGISLESYVYNILYEVM 292
                         ||...||.:|.:.||..|    |::...|...|      :::...:...|.:
Zfish   176 -------------LYTTFSICVISKYPYYNA----LRDCLSCFLFQ------MKTSRVSDFDEQV 217

  Fly   293 LPQPGKSIRVYLPPTEP-----HLPPIALILQRPLLATELPLLDFPLRLLFKYLGVECVIQLLTC 352
            .....|...|.:||:.|     :|.|:.:.|. ..|..:.|::|..|.|.|.....:.::|:::.
Zfish   218 KEFSAKLALVPIPPSGPLHVVFNLRPLQIELP-SRLDVDRPVMDLDLHLPFLCFKPKQILQIISS 281

  Fly   353 VLLENQVLLRSTDYQRLMIVGECITSLLFPFVWPHVYAPILPAALHHFLDAPVPFVMGLHAE--C 415
            :|:|.:|:..|||:.:|.:|.||....:.|..|.|.:.|:|...:..|:.||..::||.|..  .
Zfish   282 ILMEQRVVFLSTDWAKLTLVSECFMIFIHPLRWQHPFVPVLSRQMLDFIMAPTAYLMGCHTYHFQ 346

  Fly   416 EAAHKIGSEATLCFVDIDKKHIQLPEELPVFPHKVDFMAEIGSVLDKFEIERDRDQEPSFRNGYV 480
            |.|.:|   ..|..:|||:
Zfish   347 EVAEEI---EDLVLIDIDQ---------------------------------------------- 362

  Fly   481 GRGAGGGVSGSGSSGSGGVDAMISSCTLPTGLQAARRSKERFQQMQETVYTLSGSPGGGVVDYQP 545
                 |.||.|.|                          :||.
Zfish   363 -----GTVSSSTS--------------------------DRFD---------------------- 374

  Fly   546 LIAHPSRIDHVPRIAD--FLRRKGGIRGAGSPVGSPTVSLSSSPVGIYHDVDAVDAT--MPVSTR 606
                   :..||..|.  |:.|.||::                   :::|:|...::  ..|:..
Zfish   375 -------LPDVPLAARDCFIFRCGGLQ-------------------LHYDLDVCGSSSQTDVNDL 413

  Fly   607 RAEKQKLSPVDQYYQDLRINNSVREIFLNRFVHMFHAYEYFVIYPNQARDEWISNRETLQNFDKS 671
            ||.::        ....::|:|:..|.:...|::|.....|:.|.::.             |:..
Zfish   414 RAHRR--------LWQRKLNSSILNISMELIVNIFSEVCDFLNYEHRV-------------FNSE 457

  Fly   672 SFLSDQPEHHRAFLSRFLESQMFATLIDNKILAMWESQPDEQLQLFDQ--RVKLL---------- 724
            .||..:.....||..:.|::.:|.:.:..::....::....||.:..:  |:|::
Zfish   458 EFLRSRDSTDSAFYRKVLDTHIFHSFLRERLNRKNDAFTRMQLNIRSETRRLKIMTESPRRPTME 522

  Fly   725 ---RRRHGENMIAATSYEPCVLSQDSQQGFEKRLNCIDIEVTPPSEILANRAAYFRSFPLLEKGV 786
               |:...||                  |..|||.     ::.|:  ||:..:.  :.|:.:..:
Zfish   523 EINRKHRAEN------------------GLNKRLG-----MSMPN--LADSRSL--TVPIRQMSM 560

  Fly   787 LNQECASRGNSLRRVKNGNKWRAREISLDQKPGSNAINRLSANLTTADVSPALIAQANWTFVERL 851
            ::.....:..|...:|....::..|.                        |..:|   :.:|:..
Zfish   561 MSVRMPLQMGSWSPIKPVKTFKLPEF------------------------PPPLA---YHYVQNY 598

  Fly   852 LKDIKSKTKRMLLEKMGNEAVALGLKGDGIEENTLIASMCDLLEKIWSHGLQNKQGKSALWAHLQ 916
            ..|:..:..|             .:.....:::.|:|      ...:..||.|    |....|:.
Zfish   599 YHDLIGQLDR-------------SISSASPDDSALLA------RYYYLRGLVN----SVTGRHVD 640

  Fly   917 AYLEMQEARGAGDSSGTEQTPPVSSSPGGKMTIATASPALAWNAMRKRMDYLSTFQTDFDSPPSP 981
                                                  |||        |:.|.::||.:..|:
Zfish   641 --------------------------------------ALA--------DFQSLYKTDMEIFPA- 658

  Fly   982 NRSRSRDRNKFVGLEQLCPLPESLEFDVKNVLAMADIKTHIGYTRAWVRLSLEKKLLSRHFRTLL 1046
                          :.|..|.|:|..:.|.:   |:.:|.:            |:|:||..|...
Zfish   659 --------------QLLNTLVEALPVEEKRI---AERRTDL------------KRLMSRVRRENE 694

  Fly  1047 SDEALL-------------RSLYKRSAFLRCEE-------EKEQFLYHLLTLNTVD--------- 1082
            .|.|.|             :.|.|.....|.:|       |..:.|:..|||...|
Zfish   695 KDRARLVDGGTVKRFELPKKHLQKEDFVRRVQESGIVKDLETIKRLFEALTLGVEDSCRSVFYLE 759

  Fly  1083 ------------YFSFTNIYPTTKLPYRVVIFPS-------------RKYGSYHTSSNVWIMVSG 1122
                        :..|.|.:..|:...:.|..|:             :...|..||..|     |
Zfish   760 LDGQVKQVDPETFRFFYNFWKETEAAAQDVDLPAVVLEHLENDECVYKVSSSVKTSHGV-----G 819

  Fly  1123 TMNETQRVPVPKGSLEFIFHYKNLGLLTTMRIGH-------------DNSGPSHKWLVEQVVMRN 1174
            .:..|||               .|.|||..|.|:             .:|.|.....:..:.:|.
Zfish   820 KIAMTQR---------------RLFLLTEGRPGYVEITKFRDIEDVRISSAPFLLLRIPSLKIRT 869

  Fly  1175 EVTGHTY----KFPCG--------RWLGRGVDDDSTERLLVGQRVLTNAKNAELVPGS------- 1220
            .:...::    |..|.        .|.||.:.|...:...: ::.||||...:.|.||
Zfish   870 SLRRESFEANLKSECDLWHLMIKEMWAGRKMADQHKDPQFM-EQALTNALLMDAVVGSLQSQKAI 933

  Fly  1221 ------------DTRTP---PRTRSPSVQRQETLAPSEIQHQLGNCVNVLVKWHYKPSR----DR 1266
                        .:..|   |:|.|.:::.:  :.|| :.......|:||:   |.|.:    |.
Zfish   934 YAATKLAYFDKMKSEVPMMVPKTTSDTLKHK--INPS-LDQTSPQAVDVLL---YTPGQLGVSDV 992

  Fly  1267 DVGTLTNLLCG-DDG----------------------LVKCL----EQVFLCGFRSARFFGRNLY 1304
            |.|....|.|. .||                      .:.|:    ||....|.:
Zfish   993 DGGGNPKLWCALSDGKLLVFDAASWSMQHNSVQVGTSRLTCMLAVNEQQLWIGSK---------- 1047

  Fly  1305 IWDYFTKI---------KELFEHNLQ---MELEDSSSSLDSSFSNGSGSGGN-------SLQ-RR 1349
              |.|..|         |:|.||..:   :.||:.:.....:.:.......|       ||| ||
Zfish  1048 --DSFIYIINPRSVSCNKQLTEHRCELTGLALEERADKFSQTVAYSCSEDCNVIVWDVSSLQVRR 1110

  Fly  1350 EIS-SIWRLYVQLMDEINGT--ALGKDGKFQLLIC-------------LSLREHLLT 1390
            :.. |..||  |.|...||.  ..|:|       |             :||.:|||:
Zfish  1111 QFRVSCGRL--QSMHVHNGMLWCCGRD-------CVLEVRRNGSVHRRISLPDHLLS 1158

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pns	NP_647620.1	uDENN	70..171	CDD:214824	25/109 (23%)
		DENN	243..435	CDD:214823	53/198 (27%)
		dDENN	626..701	CDD:129037	14/74 (19%)
		RUN	<989..1083	CDD:295434	25/134 (19%)
		PLAT_RAB6IP1	1095..1203	CDD:238855	25/145 (17%)
		RUN	1376..1436	CDD:214736	6/28 (21%)
dennd3a	XP_021323902.1	DENN	177..363	CDD:307995	54/250 (22%)
		dDENN	425..487	CDD:129037	14/74 (19%)
		WD40	997..1283	CDD:330360	38/183 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2127
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900