DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pns and Sbf1

DIOPT Version :9

Sequence 1:	NP_647620.1	Gene:	pns / 38178	FlyBaseID:	FBgn0035229	Length:	1449	Species:	Drosophila melanogaster
Sequence 2:	XP_006521601.1	Gene:	Sbf1 / 77980	MGIID:	1925230	Length:	1901	Species:	Mus musculus

Alignment Length:	1360	Identity:	272/1360 - (20%)
Similarity:	455/1360 - (33%)	Gaps:	414/1360 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 SRFADYFVICGLDLDTGLEPDRFAGDNLHCSPLDRAYKSKPLAHYPENVPW--NPFDAHGICMLS 132
            :|.|||||:...    |..| |.:|:.          :.:.|..:||. .|  ||| ..||.:..
Mouse     2 ARLADYFVLVAF----GPHP-RGSGEG----------QGQILQRFPEK-DWEDNPF-PQGIELFC 49

  Fly   133 LPQGLRFRTQKHCIEPRFHSFATTREDGKRCYGFSLVFYEEIRNRNICGAIHTLQSMFITELSNG 197
            .|.|.:...:::  .|.|.....|..:.:|.|...|.|:|         .:.:.|.:..|:.:..
Mouse    50 QPSGWQLCPERN--PPTFFVAVLTDINSERHYCACLTFWE---------PVESTQEVVCTDNATE 103

  Fly   198 QQTHSLSRVKQDGPVSRSLPRHFKVAGQAPQSAQSYYDINKDKLYVAKSITLICQAPYAFAAQMF 262
            ::..:      ||            .|||..|:.:  .....:|:..|::.|:.:..:|...:..
Mouse   104 KEEEA------DG------------GGQARLSSTA--PAQPGQLFAPKTLVLVSRLDHAEVFRNS 148

  Fly   263 LKNLYRCLPRQPGAGISLESYVYNILYEVMLPQPGKSIRVYLPPTEPHLPPIAL------ILQRP 321
            |..:|..  ...|..:|||:.:.|:| ...:|..|.|   .|...|.....|:|      ::|.|
Mouse   149 LGLIYAI--HVEGLNVSLENVIGNLL-TCTVPLAGGS---QLDSVEEGARTISLGAGDRQVIQTP 207

  Fly   322 LLATELPLLDFPLRLLFKYLGVECVIQLLTCVLLENQVLLRSTDYQRLMIVGECITSLLFPFVWP 386
            |: ..||:....:.|||:.||:..|:.|....|.|::||..|..||||......:.:||||..:.
Mouse   208 LV-DSLPVSRCSVALLFRQLGITNVLSLFCAALTEHKVLFLSRSYQRLADACRGLLALLFPLRYS 271

  Fly   387 HVYAPILPAALHHFLDAPVPFVMGLHAECEAAHKIGSEATLCFVDIDKKHIQLPEELPVFPHKVD 451
            ..|.|||||.|...|..|.||::|::|.
Mouse   272 FTYVPILPAQLLEVLSTPTPFIIGVNAA------------------------------------- 299

  Fly   452 FMAEIGSVLDKFEIERDRDQEPSFRNGYVGRGAGGGVSGSGSSGSGGVDAMISSCTLPTGLQAAR 516
            |.||...:||....:.|                ||.|:             :..|.
Mouse   300 FQAETQELLDVIVADLD----------------GGTVT-------------VPECV--------- 326

  Fly   517 RSKERFQQMQETVYTLSGSPGGGVVDYQPLIAHPSRIDHVPRIADFLRRKGGIRGAGSPVGSPT- 580
                                                  |:|.:.:             |:.|.|
Mouse   327 --------------------------------------HIPPLPE-------------PLQSQTH 340

  Fly   581 --VSLSSSPVGIYHDVDAVDATMPVSTRRAEKQKLSPVDQYYQDLRINNSVREIFLNRFVHMFHA 643
              :|:...|     :::..|...|..|..|...|:       ||    ..:|.:||..|..:...
Mouse   341 NVLSMVLDP-----ELELADLAFPPPTTSASSLKM-------QD----KELRAVFLRLFAQLLQG 389

  Fly   644 YEYFV----IYPNQARDEWISNRETLQNFDKSSFLSDQPEHHRAFLSRFLESQMFATLIDNKILA 704
            |.:.:    |:|           |.:..|.|::||..:......||.:.||...||..:..:
Mouse   390 YRWCLHIVRIHP-----------EPVIRFHKAAFLGQRGLVEDDFLMKVLEGMAFAGFVSER--- 440

  Fly   705 MWESQPDEQLQLFDQRV--KLLRRRHGENMIAATSYEPCVLS--QDSQQGFEKRLNCIDI----E 761
               ..|.....|||:.|  ::.|.|..|      |:...||.  |:..:...|..|....    :
Mouse   441 ---GVPYRATDLFDELVAHEVARMRADE------SHPHRVLRHVQELAEQLYKNENPYPAVAMHK 496

  Fly   762 VTPPSEILANRAAYFRSFPLLEKG----VLNQECASRGNSLRRVKNGNKWRAREISLDQKPGSNA 822
            |..|.|....|..: |.||.|::|    :::|..|....:...||     ..|..::...|...|
Mouse   497 VQRPGEASHLRRTH-RPFPRLDEGTIQWIVDQAAAKMQGAPPAVK-----AERRSTVPSGPPMTA 555

  Fly   823 I-NRLSA-NLTTADVSPALIAQANWTFVERLLKDIKSKTKRMLLEKMGNEAVALGLKGDGIEENT 885
            | .|.|. ::.:|.....:....::.|..::|     :.|::|      .||...|||..
Mouse   556 ILERCSGPHINSARRLEVVRNCISYVFEGKML-----EAKKLL------PAVLRALKGRA----- 604

  Fly   886 LIASMCDLLEKIWSHGLQNKQGKSALWAHLQAYLE-------MQEARGAGDSSGTEQT--PPVSS 941
              |..| |..::..|..||:    |:..|.|....       :|:.... |..|....  |.|::
Mouse   605 --ARRC-LAHELHLHVQQNR----AVLDHQQFDFVVRMMNCCLQDCTSL-DEHGIASALLPLVTA 661

  Fly   942 -----SPGGKMT----------IATASPALAWNAMRKRMDYLSTFQTDFDS---PPSPNRSRSRD 988
                 |||  :|          :..::|.. |.||     :....||...:   .||...|.:::
Mouse   662 FCRKLSPG--VTQFAYSCVQEHVVWSTPQF-WEAM-----FYGDVQTHIRALYLEPSDGVSPTQE 718

  Fly   989 RNKFVGLEQLCPLPESLEFDVKNVLAMADIKTHIGYTRAWVRLSLEK--KLLSRHFRTLLSDEAL 1051
            ..:           ...:.|.::.|.:|..:     .|.|..||.||  :|:.:...|:.| :|:
Mouse   719 TGE-----------AQSQDDERSALDVASEQ-----RRLWPTLSREKQQELVQKEESTVFS-QAI 766

  Fly  1052 LRSLYKRSAFLRCEEEKEQFLYHLLTLNTVDYFSFTNIYPTTKLPYRVVIFPSRKYGSYHTSSNV 1116
            ..:.......|..:..|.:.|.....|.  |..|.:|...|..:...|.       .||.|.|.
Mouse   767 HYANRMSYLLLPLDSSKSRLLRERAGLG--DLESASNSLVTNSMAGSVA-------ESYDTESG- 821

  Fly  1117 WIMVSGTMNETQRVPVPKGSLEFIFHYKNLGLLTTMRIGHDNSGPSHKWLVEQVVMRNEVTGHTY 1181
                   ..:.:...|....:.||..:                       |::|...:.||....
Mouse   822 -------FEDAETCDVAGAVVRFINRF-----------------------VDKVCTESGVTSDHL 856

  Fly  1182 KFPCGRWLGRGVDDDSTERLLVGQRVLTNAKNAELVPGSDTRTPPRTRSPSVQRQETLAPSEIQH 1246
            |         |:      .::|...|..:.:..|.|.....|.||      :|:.:.|.|..:..
Mouse   857 K---------GL------HVMVPDIVQMHIETLEAVHRESKRLPP------IQKPKLLRPRLLPG 900

  Fly  1247 QLGNCVNVLVKWHYKP-SRDRDVGTLTN---LLCGDDGLVKCLEQVFLCGFRSARFFGRNLYIWD 1307
            :  .||...::.:..| .|:..||....   ||..:..:.....:|...|..:....|..:.:..
Mouse   901 E--ECVLDGLRVYLLPDGREEGVGGSGGGPALLPAEGAVFLTTYRVIFTGMPTDPLVGEQVVVRS 963

  Fly  1308 Y-------------FTKIKELFEHNLQMELEDSSSSLDSSFSNGSGSGGNSLQRREISSI 1354
            :             .|.:.:|.:..||:. ..:...|..:|....||....|.|:::..:
Mouse   964 FPVAALTKEKRISVQTPVDQLLQDGLQLR-SCTFQLLKMAFDEEVGSDSAELFRKQLHKL 1022

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pns	NP_647620.1	uDENN	70..171	CDD:214824	27/102 (26%)
		DENN	243..435	CDD:214823	56/197 (28%)
		dDENN	626..701	CDD:129037	18/78 (23%)
		RUN	<989..1083	CDD:295434	17/95 (18%)
		PLAT_RAB6IP1	1095..1203	CDD:238855	14/107 (13%)
		RUN	1376..1436	CDD:214736
Sbf1	XP_006521601.1	uDENN	1..86	CDD:214824	27/102 (26%)
		DENN	129..318	CDD:214823	62/248 (25%)
		dDENN	372..440	CDD:129037	19/82 (23%)
		SBF2	551..772	CDD:372054	55/269 (20%)
		PH-like	901..1019	CDD:388408	21/120 (18%)
		PTP_DSP_cys	1158..1530	CDD:391942
		PH_Sbf1_hMTMR5	1794..1899	CDD:269941
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2127
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900