DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pns and dennd4c

DIOPT Version :9

Sequence 1:	NP_647620.1	Gene:	pns / 38178	FlyBaseID:	FBgn0035229	Length:	1449	Species:	Drosophila melanogaster
Sequence 2:	XP_005166610.1	Gene:	dennd4c / 558626	ZFINID:	ZDB-GENE-120727-13	Length:	1943	Species:	Danio rerio

Alignment Length:	1622	Identity:	300/1622 - (18%)
Similarity:	503/1622 - (31%)	Gaps:	564/1622 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 ICGLDLDTGLEPDRF---AGDNLHC----------------SPLDRAYKSKPLAHYPENVPWNPF 123
            ||.:..:.|..|...   ...||:|                |....|||:..:..|||. .:..|
Zfish   158 ICVIITNKGETPPHTFCKVDKNLNCGMWGSSVFLCYKKSVSSSNSIAYKAGLIFRYPEE-DYESF 221

  Fly   124 D-AHGICMLSLPQGLRFRTQKHCIEPR-------FHSFATTREDGKRCYGFSLVFYEEIRNRNIC 180
            . :..:.:..||.|.:.    .|..|.       |.:|..|..:|::.||..:.|||...
Zfish   222 PLSESVPLFCLPMGAKI----ECWAPNTRYPLPVFSTFVLTNSNGEKVYGAGIQFYEPYP----- 277

  Fly   181 GAIHTLQSMFITELSNGQQTHSLSRVKQDGPVS----RSLPRHFKVAGQAPQSAQSYYDINKDKL 241
                      :..||..|:.       |.|.||    :.||..               .:|.:
Zfish   278 ----------VDGLSEKQKI-------QLGLVSAVDKKVLPNR---------------TVNTN-- 308

  Fly   242 YVAKSITLICQAPYAFAAQMFLKNLYRCLPRQPGAGISLESYVYNILYEVMLPQPGK-SIRVYLP 305
               |.|.|:.:.|:..|.:.||..||: |.....:.:.:|.::.:.::.|..|.|.: .|.|.|.
Zfish   309 ---KCICLLSRWPFFEAFRKFLMFLYK-LSANGVSPLPIEKHISHFMHNVSFPSPQRPRILVQLS 369

  Fly   306 PTEPHLPPIALILQRPLLATELPLLDFPLRLLFKYLGVECVIQLLTCVLLENQVLLRSTDYQRLM 370
            ..:      .|||.:| :.|.|||.......|...||.|....||..||||:::||.|.....|.
Zfish   370 AHD------TLILSQP-VCTPLPLSGADYSTLLMNLGPENCATLLHFVLLESKILLHSLRPAVLT 427

  Fly   371 IVGECITSLLFPFVWPHVYAPILPAALHHFLDAPVPFVMGLHAECEAAHKIGSEATLCFVDIDKK 435
            .|.|.:.:::|||.|...|.|:.|.:|...|:||.||::|:.:.....:....: .:| ||:|..
Zfish   428 GVAEAVVAMIFPFQWQCPYIPLCPLSLAGVLNAPCPFIVGVDSRYFDLYDPPPD-VVC-VDLDTN 490

  Fly   436 HIQLPEE--------LPVFPHK--VDFMAEIGSVLDKFEIERDRDQEPSFRNGYVGRGAGGGVSG 490
            .|.|.:|        ||..|.|  :.|:..:...|                 ..|.|.|..|::
Zfish   491 TIYLSDEKRHSNWKNLPKKPSKSLISFLGSLHHQL-----------------ATVRRTATEGLA- 537

  Fly   491 SGSSGSGGVDAMISSCTLPTGLQAARRSKERFQQMQETVYTLSGSPGGGVVDYQPLIAHPSRIDH 555
                                                                          ::.
Zfish   538 --------------------------------------------------------------VEM 540

  Fly   556 VPRIADFLRRKGGIRGAGSPVGSPTVSLSSSPVGIYHDVDAVDATMPVSTRRAEKQKLSPVDQYY 620
            .|..|||...|                                       ::.|
Zfish   541 TPIEADFTWHK---------------------------------------KKTE----------- 555

  Fly   621 QDLRINNSVREIFLNRFVHMFHAYEYFVIYPNQARDEWISNRETLQNFDKSSFLSDQPEHHRAFL 685
                :...::|:||.....:...|..::....||..|..:..::|  :|...||..:...|:.|.
Zfish   556 ----LEMEIQEVFLRFMASILKGYRTYLKPITQAPSEKATAADSL--YDLQGFLKSRDRAHQKFY 614

  Fly   686 SRFLESQMFATLIDNKILAMWESQPDEQLQLFDQRVKLL-----RRRHGENMIAATSYEPCVLSQ 745
            |:..::|:|...::.   ..:.|..|..|..||..::.|     ....|..:...:|.:..::..
Zfish   615 SQLTKTQIFIRFVEE---CTFVSDKDTGLAFFDDCIRKLFPSDKGTDKGTKVEGESSEDTRLMEL 676

  Fly   746 DSQQGFEKRLNCIDIEVTPPSEILAN------RAAYFRSFPLLEKGVLNQECASR--------GN 796
            |..|..|.     .:.|.||...|.:      :.:| ::||.|...:.::....|        |:
Zfish   677 DESQKSEH-----TVFVMPPEPPLEDGPDPPPKYSY-KNFPSLRLELFDRPLELRPALSTRAAGS 735

  Fly   797 SL--------RRVK---------------NGNKWR----------------AREISLDQKPGS-- 820
            |:        :|.|               |..:|.                ||..:...||.:
Zfish   736 SVSSSPALLAKRTKQEIKMAYKLAKRFYSNPPQWAKCLCSHCYSLWFICLPARMRTAQSKPRAMQ 800

  Fly   821 NAIN-----------------------------------RLSANLTTADVSPALIAQA------- 843
            .|.|                                   |:...:..|.|.|..|...
Zfish   801 QAFNVLLKMRSSEVEVLDEVCYRVVMQLCGLWEMPVMAVRVLMEMKKAGVEPNAITYGYYNKAVL 865

  Fly   844 -------------NWTFVERLLKDIKSKTKRML---LEKMGNE--------AVALGLKG------ 878
                         .||.:..|::.: .:.||.|   ..::|:.        :.|:|..|
Zfish   866 ESPWPSRNRSGLFMWTKMRNLVRGV-VQFKRALRGTTLQIGSSLKSTDLSASTAVGADGDRLSHG 929

  Fly   879 --DGIEENTLIASMCDLLEKIWSHGLQNKQGKSALWAHLQAYLEMQEARGAGDSSGTEQT-PPVS 940
              |||.|..::.|...|:|.:             :.:|.....:..:..|:.|....|.| .||:
Zfish   930 SVDGIVEEHILFSHSILVEDV-------------IDSHYSTAAQSDQGYGSKDELPQEHTEEPVT 981

  Fly   941 SSPGGKMTIATASPALAWNAMRKR-MDYLSTFQT--DFDSPPSPNRSRSRDRNKFVGLEQLCPLP 1002
            |.|     ::|.....:.....|. .|..|:..:  ....||||              .::.|..
Zfish   982 SPP-----LSTNHTCSSKETNTKNGQDIASSVDSVVAVTEPPSP--------------AEIAPCV 1027

  Fly  1003 ESLEFDVKNVLAMADIKTHIGYTRA-------------WVRLSLEKKLLSRHFRTLLSDEALLRS 1054
            .|:      |....||..|...|..             ..|...|...||....|::.|..|.:|
Zfish  1028 ASI------VKPSTDIPVHFDSTAGRGETAGVCTGKLFMSRKKSEDVALSVEDATVIPDSQLPQS 1086

  Fly  1055 LYKR--SAFLR--CE---EEKEQFLYHLLTLN-TVDY-----------FS-------FTNIYPTT 1093
            ..::  .||:.  |.   |.|...|....:|. :.|:           ||       |.:|.|..
Zfish  1087 GQQQRVKAFMERSCSFSAESKAGMLQKKSSLELSADHMGADAKILAAVFSGSQTPPPFASIAPFK 1151

  Fly  1094 KLPYRVVIFPS-----------RKYGSYHTSSNVWIMVS-------GTMNETQRVPVPKGSLEFI 1140
            :......:.|:           .|:.|: ||:...:..|       ...|.::||....||
Zfish  1152 EFKVEATLSPALQEEEQEEKQETKHESF-TSAAEGVEKSIKRDNAAAESNSSERVGRTTGS---- 1211

  Fly  1141 FHYKNLGLLTTMRIGHDN----SGPSHKWLVEQVVMRNEVTG-----HTYKFPCGRWLGRGVDDD 1196
                  .:.::..:..:|    :.|...:..|    ..:.|.     .|..||  ..:.|.:.|:
Zfish  1212 ------AVSSSKAVERENVEMGADPLSLFASE----TEDTTSIQSQESTRTFP--PLVSRNLADE 1264

  Fly  1197 STERLLVGQRVLTNAKNAELVPGSDTRT-----PPRTR-------------------------SP 1231
            ....:.:...:...:.:.||..||:..:     .|..:                         ||
Zfish  1265 IEMYMSLQSPLTARSPSMELQQGSNPESINCPDSPAVKQSLERRSSLPIGPVKVASSTEHPKPSP 1329

  Fly  1232 SVQRQETLAPSEIQ-----HQLGNCVNVLVKWHYKPSRDRDVGTLTNLLCG---DDGLVKCLEQV 1288
            :|.|.:|.|....:     .|..:.:..||    |.|::..:|::.|.:.|   |..||.....:
Zfish  1330 AVTRSKTFAVKSPKTPGSAGQRSSSLTALV----KSSQNSSLGSVINSISGIKMDSLLVGPKVDM 1390

  Fly  1289 FLCGFRSARFFGRNLYIWD-----YFTKIKELFEHNLQMELEDSSSSLDSSFSNGSGSGGNSLQR 1348
            ...|.:.|......:  ||     |.....|  |.||:.:. ...:.|:....:|.|...|:|.|
Zfish  1391 LKSGMKQAANVASKM--WDAVASAYSYSDDE--EDNLKPQY-SFPARLEEQLLSGEGDTENTLPR 1450

  Fly  1349 REISSIWRLYVQLMDEINGTALGKDGKFQLLICLSLREHLLTRLIKPMALTKVTHEMYEEES 1410
            ..:.|:....:...:...|::.|.....|        .||.|.|....::.....|..|..|
Zfish  1451 GLMPSLGSNGLAHSNTSLGSSSGSSDTGQ--------AHLSTPLTPGRSMRGADSERSEHSS 1504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pns	NP_647620.1	uDENN	70..171	CDD:214824	26/119 (22%)
		DENN	243..435	CDD:214823	59/192 (31%)
		dDENN	626..701	CDD:129037	16/74 (22%)
		RUN	<989..1083	CDD:295434	22/114 (19%)
		PLAT_RAB6IP1	1095..1203	CDD:238855	20/134 (15%)
		RUN	1376..1436	CDD:214736	8/35 (23%)
dennd4c	XP_005166610.1	DUF2464	40..>205	CDD:287242	8/46 (17%)
		uDENN	190..273	CDD:214824	19/87 (22%)
		DENN	307..490	CDD:280329	59/197 (30%)
		dDENN	557..630	CDD:129037	16/77 (21%)
		PPR_2	818..857	CDD:289786	5/38 (13%)
		PPR repeat	819..848	CDD:276811	1/28 (4%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910