DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment pns and dennd4a

DIOPT Version :9

Sequence 1:NP_647620.1 Gene:pns / 38178 FlyBaseID:FBgn0035229 Length:1449 Species:Drosophila melanogaster
Sequence 2:XP_005159157.1 Gene:dennd4a / 558211 ZFINID:ZDB-GENE-060503-285 Length:1724 Species:Danio rerio


Alignment Length:1341 Identity:248/1341 - (18%)
Similarity:404/1341 - (30%) Gaps:544/1341 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   105 AYKSKPLAHYPENVPWNPFDA----HGICMLSLPQGLRFRT----QKHCIEPRFHSFATTREDGK 161
            |:|:..|:.|||    ..:|:    ..:.:..||.|.....    .|:.: |.|.:|..|...|:
Zfish   206 AFKAGLLSRYPE----EDYDSFPLPESVPLFCLPMGASIECWSSHTKYSL-PVFSTFVLTGASGE 265

  Fly   162 RCYGFSLVFYEEIRNRNICGAIHTLQSMFITELSNGQQTHSLSRVKQDGPVSRSLPRHFKVAGQA 226
            :.||.::.|||.....:            :||....|.....:.::.||.::             
Zfish   266 KVYGAAIQFYEPYPEEH------------LTEKQRSQLGLQANGIRPDGSMT------------- 305

  Fly   227 PQSAQSYYDINKDKLYVAKSITLICQAPYAFAAQMFLKNLYRCLPRQPGAGISLESYVYNILYEV 291
                          ::..|||.|:...|:..|.:.||..|||.....|.. :.:|.::.:.:::|
Zfish   306 --------------VHTNKSICLLSHWPFFDAFRNFLTFLYRYSISGPHT-LPIEKHISHFMHKV 355

  Fly   292 MLPQPGK-SIRVYLPPTEPHLPPIALILQRPLLATELPLLDFPLRLLFKYLGVECVIQLLTCVLL 355
            ..|...: .|.|.|.|.:      :|:|.:| :::.|||....|..|...||.:....||...:.
Zfish   356 PFPSSQRPRILVQLSPHD------SLMLSQP-VSSPLPLSGGRLSTLLLNLGPKNAATLLVLAVT 413

  Fly   356 ENQVLLRSTDYQRLMIVGECITSLLFPFVWPHVYAPILPAALHHFLDAPVPFVMGLHAECEAAHK 420
            |:::|:.|.....|..|.|.:.|::|||.||..|.|:.|.||...|.||.||::|:.:.....::
Zfish   414 EHKILVHSLRPAVLTSVTEALVSMIFPFHWPCPYIPLCPLALADVLSAPCPFIVGVDSRYFDLYE 478

  Fly   421 IGSEATLCFVDIDKKHIQLPEE--------LP--VFPHKVDFMAEIGSVLDK-FEIERDRDQEPS 474
            ..::.: | ||:|...|...||        ||  ...|.::.::.:...||: :::.|:..|..:
Zfish   479 PPTDIS-C-VDLDTNTITHKEERRSLTWKILPRKACKHLINTLSNLHQQLDEGYQMSREEGQMEA 541

  Fly   475 FRNGYVGRGAGGGVSGSGSSGSGGVDAMISSCTLPTGLQAARRSKERFQQMQETVYTLSGSPGGG 539
            |.:             ....||||                  :|.|                   
Zfish   542 FMS-------------EREPGSGG------------------KSLE------------------- 556

  Fly   540 VVDYQPLIAHPSRIDHVPRIADFLRRKGGIRGAGSPVGSPTVSLSSSPVGIYHDVDAVDATMPVS 604
                                                    |:.|                     
Zfish   557 ----------------------------------------TLEL--------------------- 560

  Fly   605 TRRAEKQKLSPVDQYYQDLRINNSVREIFLNRFVHMFHAYEYFVIYPNQARDEWISNRETLQNFD 669
                                   .::|.||.....:...|..:::...||..|..::..:|  ||
Zfish   561 -----------------------EIQEAFLRFMAAILKGYRSYLLPITQAPSEKATDASSL--FD 600

  Fly   670 KSSFLSDQPEHHRAFLSRFLESQMFATLIDNKILAMWESQPDEQLQLFDQRV-KLLRRRHGENMI 733
            ...||..:...|:.|.|...::|||...|:.   ..:.|..|..|..||..| ||.....|..: 
Zfish   601 LQGFLKSRDRSHQKFYSLMTKTQMFIRFIEE---CSFVSDKDASLAFFDDCVDKLFGTEKGGKV- 661

  Fly   734 AATSYEPCVLSQDSQQGFEKRLNCID--------IEVTPPSEILANRAAYFRSFPLLEKG----- 785
                        ||.:..:.||..:|        :.::||            ..|.|.:|     
Zfish   662 ------------DSDKPEDTRLIELDKSHRSEHTVFISPP------------ELPALPEGEEPPM 702

  Fly   786 --------VLNQECASRGNSLRRVKNGNKWRAREISLDQKPGSNAINRLSANLTTADVSPALI-- 840
                    .||.:.....:.||..|                .::|:..:|      .:|||.|  
Zfish   703 VYSYSGFPALNAQLCEHQDGLRVPK----------------ATSALRHIS------PISPAAIFR 745

  Fly   841 -AQANWTFVERLLKDIK------------------------------SKTK-------------- 860
             :|......:|:.|...                              ||.:              
Zfish   746 RSQQEIKSAQRMAKTYSSIPQMWSKCLLRHCHGLWFICLPAYVSACHSKVRALHTAYDVLRNMQD 810

  Fly   861 -----------RMLLEKMGNEA-------VALGLKGDGIEENTLIASMCD--LLEKIWSHGLQNK 905
                       |:|::..|...       |...:|..|::.|.:.....:  :||..|.   .:.
Zfish   811 KKLQPPDEVCYRVLMQLCGQYGQPVLAVRVLFEMKKAGVQPNAITYGYYNRAVLESTWP---SST 872

  Fly   906 QGKSALW--------------------------AHLQAYLEMQE-ARGAGDSSG---------TE 934
            :|...||                          .||....::.. :.|:.|||.         |:
Zfish   873 RGGYFLWGKLRNVVRGVVLFKQVWRRQTTHPKDTHLSDASDLDSVSHGSLDSSNDSAERVSIDTD 937

  Fly   935 QTPPVS----SSPGGKMTIATASPALAWNAMRKRMDYLSTFQTDF----DSPPSPNRSRSRDRNK 991
            .|...|    ||.||:..              :..|.||..:..|    :...||:....:||:.
Zfish   938 FTKMDSSDDRSSTGGQSD--------------QGYDSLSKEEVRFGGGEEQNSSPDIKEKKDRDS 988

  Fly   992 FVGLEQLCPLPESLEFDVKNVLAMADIKTHIGYTRAWVRLSLEKKLLSRHFRTLLSDEALLRSLY 1056
                   ||..:|                           .|.||          .|.:|...: 
Zfish   989 -------CPSSQS---------------------------ELSKK----------EDSSLAAGI- 1008

  Fly  1057 KRSAFLRCEEEKEQFLYHLLTLNTVDYFSFTNIYPTTKLPYRVVIF-------------PSRKYG 1108
                             |...:|.....:|:|..|.||.|..:.||             |.:...
Zfish  1009 -----------------HPPEINKESSQAFSNTIPKTKRPNSLDIFGEKPVRPNTLDLTPDKPVD 1056

  Fly  1109 SYHTSSNVWIMVSGTMNETQR--VPVPKGSLEFIFHYKNLGLLTTMRIGHDNSGPSHKWLVEQVV 1171
            |        :.|:.|..|...  |..||.|:|     :......||.              :.|.
Zfish  1057 S--------VPVAQTQTEALEGVVSPPKVSVE-----RKASCTVTME--------------KTVA 1094

  Fly  1172 MRNEVTGHTYKFPCGRWLGRGVDDDSTE------RLLVGQRVLTNAKNAELVPGSDTRTPPRTRS 1230
            |.:..||......|...|.|.|.....|      .|:..:   |:....|...|          :
Zfish  1095 MESGHTGVERSMSCNSALSRVVKRTGIEAGFDPLSLMAAE---THGHEDEDNAG----------T 1146

  Fly  1231 PSVQRQETLAPSEIQHQLGN--------CVNVLVKWHYKPS 1263
            ||.:|.  || .||.|.:.|        .::|.:|.|..||
Zfish  1147 PSARRD--LA-EEIHHYMNNLSSPLSQRSLSVDLKGHQTPS 1184

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pnsNP_647620.1 uDENN 70..171 CDD:214824 18/73 (25%)
DENN 243..435 CDD:214823 58/192 (30%)
dDENN 626..701 CDD:129037 19/74 (26%)
RUN <989..1083 CDD:295434 11/93 (12%)
PLAT_RAB6IP1 1095..1203 CDD:238855 25/128 (20%)
RUN 1376..1436 CDD:214736
dennd4aXP_005159157.1 DUF2464 44..>198 CDD:287242
uDENN 168..275 CDD:214824 18/73 (25%)
DENN 307..491 CDD:280329 58/193 (30%)
dDENN 559..632 CDD:129037 20/121 (17%)
PPR_2 816..856 CDD:289786 7/39 (18%)
PPR repeat 818..847 CDD:276811 5/28 (18%)
PPR 819..853 CDD:273253 6/33 (18%)
SEEEED 921..1003 CDD:291463 25/139 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3728
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.940

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