DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pns and Dennd4c

DIOPT Version :9

Sequence 1:	NP_647620.1	Gene:	pns / 38178	FlyBaseID:	FBgn0035229	Length:	1449	Species:	Drosophila melanogaster
Sequence 2:	XP_006538085.1	Gene:	Dennd4c / 329877	MGIID:	1914769	Length:	1955	Species:	Mus musculus

Alignment Length:	1510	Identity:	286/1510 - (18%)
Similarity:	493/1510 - (32%)	Gaps:	505/1510 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 AYKSKPLAHYP----ENVPWNPFDAHGICMLSLPQGLRFRTQKHCIEPR-------FHSFATTRE 158
            |||:..:..||    |:.|.:|    .:.:..||.|...    .|.:|:       |.:|..|..
Mouse   206 AYKAGLIFRYPEEDYESFPLSP----SVPLFCLPMGATI----ECWDPQIKYPLPVFSTFVLTGS 262

  Fly   159 DGKRCYGFSLVFYEEIRNRNICGAIHTLQSMFITELSNGQQTHSLSRVKQDGPVSRSLPRHFKVA 223
            ..::.||.::.|||......       |....:|:|  |..|....||     ||:
Mouse   263 SAEKVYGAAIQFYEPYSQER-------LTEKQLTQL--GLLTLVEKRV-----VSK--------- 304

  Fly   224 GQAPQSAQSYYDINKDKLYVAKSITLICQAPYAFAAQMFLKNLYRCLPRQPGAGISLESYVYNIL 288
                       .||.:     |.|.|:...|:..|.:.||..:|:.....|.. :.:|.::.:.:
Mouse   305 -----------PINSN-----KCICLLSHWPFFEAFKNFLMFIYKVSVSGPHP-LPIEKHISHFM 352

  Fly   289 YEVMLPQPGK-SIRVYLPPTEPHLPPIALILQRPLLATELPLLDFPLRLLFKYLGVECVIQLLTC 352
            ..:..|.|.: .|.:.|...:      |.||.:| ::|.|||.......|...||.|....||..
Mouse   353 QNIPFPSPQRPRILIQLSVHD------AFILSQP-VSTPLPLSGANFSSLLMNLGPENCATLLLL 410

  Fly   353 VLLENQVLLRSTDYQRLMIVGECITSLLFPFVWPHVYAPILPAALHHFLDAPVPFVMGLHAECEA 417
            ||||:::||.|.....|..|.|.:.:::|||.|...|.|:.|.:|...|.||:||::|:.:....
Mouse   411 VLLESKILLHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLSLAGVLSAPLPFIVGVDSRYFD 475

  Fly   418 AHKIGSEATLCFVDIDKKHIQLPEE--------LPVFPHKVDFMAEIGSVLDKFE----IERDRD 470
            .|. ..:..:| :|:|...:.:.:|        ||..|.|    :.:|::...::    :.| :.
Mouse   476 LHD-PPQDVVC-IDLDTNTLYVADERKNINWKQLPKRPCK----SLLGTLRRLYQQLCSVHR-KP 533

  Fly   471 QEPSFRNGYVGRGAGGGVSGSGSSGSGGVDAMISSCTLPTGLQAARRSKERFQQM----QETVYT 531
            ||                               ||....|.::|....:::..|:    |||...
Mouse   534 QE-------------------------------SSAIEMTPIEADYSWQKKMTQLEMEIQETFLR 567

  Fly   532 LSGSPGGGVVDY-QPLIAHPSRIDHVPRIADFL-RRKGGIRGAGSPVGSPTVSLSSSPV------ 588
            ...|...|...| :|:...||   :....||.| .|:|.::............||.:.:
Mouse   568 FMASILKGYRSYLRPITEAPS---NKATAADSLFDRQGFLKSRDRAYTKFYTLLSKTQIFIRFIE 629

  Fly   589 ----------GIYHDVDAVDATMP-VSTRRAEKQKLSPVDQYYQDLR---INNSVREIFLNRFVH 639
                      |:....|.::...| ....|.||..|...    :|.|   :::|.|.
Mouse   630 ECSFVSDKDTGLAFFDDCIEKLFPDKGVERTEKVDLDSA----EDTRLIELDDSQRS-------- 682

  Fly   640 MFHAYEYFVIYPNQARDEWISNRETLQNFDKSSFLSDQPEHHRAFLSRFLESQMFATLIDNKILA 704
               .:..|::.|....|:             .:.||  |::...:..|.
Mouse   683 ---EHTVFIMPPEPPPDD-------------GNNLS--PQYSYTYFPRL---------------- 713

  Fly   705 MWESQPDEQLQLFD--QRVKLLRRRHGENMIAATSYEPCVLSQDSQQGFE------KRLNCIDIE 761
                    .|:|||  |::||...||...  ::.:..|.::::.::|..:      ||  |.
Mouse   714 --------DLKLFDSPQKLKLCFNRHPPG--SSITNSPALMAKRTKQEIKTAHKLAKR--CY--- 763

  Fly   762 VTPP--SEILANRA---------AYFR-SFPLLEKGVLNQECASRGNSLRRVKNGNKWRAREISL 814
            ..||  ::.|.:..         ||.| |.|                .:|.::..:....:....
Mouse   764 TNPPQWAKYLFSHCYSLWFICLPAYVRVSHP----------------KVRALQQAHDVLVKMRKT 812

  Fly   815 DQKPGSNAINRLSANLTTADVSPALIAQA------------------------------------ 843
            |..|......|:...|....|:|.|..:.
Mouse   813 DVDPLDEVCYRVVMQLCGLWVNPVLAVRVLFEMKTARIKPNAITYGYYNKVVLESPWPSSTRSGI 877

  Fly   844 -NWTFVERLLKDIKSKTKRMLLEKMGNEA----------VALGLKGDGIEENTLIAS-------- 889
             .||.|..::..:..  .|..|:|.|.::          .|.|..||.:...::.:|
Mouse   878 FLWTKVRNVVHGLAQ--FRQPLKKTGQKSQVFSISAPQNAACGSDGDTVSHGSVDSSNDANNGEH 940

  Fly   890 ---MCDL--LEKIWSH---GLQNKQGKSALWAHLQAYLEMQE--ARGAGDSSGTEQTPP------ 938
               :.||  |:.|.:|   |.|:.||          |....|  ..||...:..|.|||
Mouse   941 TVFVRDLISLDSIDNHSSTGGQSDQG----------YGSKDELVKEGADGHAPEEHTPPELTTTE 995

  Fly   939 ------------VS-----------------------------------SSPGGKMTIATASPAL 956
                        ||                                   :|.|...|:..::.|.
Mouse   996 LHIEEECDISAIVSKHLQPTPEPQSPTEPPAWGSSIVKVPSGLFDTNNRTSTGSTSTVLFSTQAP 1060

  Fly   957 AWNAM-------RKRMDYLSTFQTDFDSPPSPNRSRSRDRNKFVGLEQLCPLPESLEFDVKN--- 1011
            ..:|:       :|..|.....|..|     |.||.|.......|:     |.:....|:.:
Mouse  1061 VEDAVFSEVTNFKKNGDRGEKKQKHF-----PERSCSFSSESRAGM-----LLKKSSLDLNSSEM 1115

  Fly  1012 -VLAMADIK-------------THIGYTRAWVRLSLEKKLLSRHF---RTLLSDEALLRSLYKRS 1059
             ::..||.|             .|:..|.::..::.       |.   ||.:| |....|.::.|
Mouse  1116 AIMMGADAKILTAALTCPKTSPPHVTRTHSFENVNC-------HLADSRTRMS-EGTRDSEHRSS 1172

  Fly  1060 AFLRCEEEKEQFLYHL-----------LTLNTVDYFSFTNIYPTTKLPYRVVIFPSRKYGSYHTS 1113
            ..|...||.::.|..:           :|.|::...|.::....|:...:..:  :::..||.|.
Mouse  1173 PVLEMLEESQELLEPVVGDNVAETAAEMTCNSLQSNSHSDQSRDTQAGAQDPV--NKRSSSYATR 1235

  Fly  1114 SNVWIMVSGTMNETQRVPVPKGSLEFIFHYKNLGLLTTMRIGHDNSGPSHKWLVEQVVMRN---E 1175
            ..:           :|..|..|       ...|.||.|..:  :.:..|...|...|:.||   |
Mouse  1236 KAI-----------EREDVETG-------LDPLSLLATECV--EKTSDSEDKLFSPVISRNLADE 1280

  Fly  1176 VTGH-TYKFPCG------RWLGRGVDDDSTERLLVGQRVLTNAKNAELVPGSDTRTPPRTRSPSV 1233
            :..: ..|.|.|      ...|.|..:..:..:.......:::..::..|.:...|.....||:|
Mouse  1281 IESYMNLKSPLGSKSCSMELHGEGNQEPGSPAVFAHPLERSSSLPSDRGPPARDSTETEKSSPAV 1345

  Fly  1234 QRQETL-------APSEIQHQLGNCVNVLVKWHYKPSRDRDVGTLTNLLCG---DDGLVKCLEQV 1288
            ...:||       :|..........::.||    :.|.:..:|::.|.|.|   |:.|......|
Mouse  1346 SSSKTLTGRFKPQSPYRAYKDRSTSLSALV----RSSPNSSLGSVVNSLSGLKLDNILSGPKIDV 1406

  Fly  1289 FLCGFRSARFFGRNLYI-----WDYFTKIKE----------LFEHNL---------------QME 1323
            .....:.|......:::     :.|....:|          |.:|::               ..|
Mouse  1407 LKSSMKQAATVASKMWVAVASAYSYSDDEEETNKDYSFPAGLEDHHIVGETLSPNTSVSGLVPSE 1471

  Fly  1324 LEDSSSSLDSSFSNG 1338
            |..|::||.||.|:|
Mouse  1472 LTQSNTSLGSSSSSG 1486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pns	NP_647620.1	uDENN	70..171	CDD:214824	18/76 (24%)
		DENN	243..435	CDD:214823	56/192 (29%)
		dDENN	626..701	CDD:129037	9/74 (12%)
		RUN	<989..1083	CDD:295434	21/124 (17%)
		PLAT_RAB6IP1	1095..1203	CDD:238855	21/117 (18%)
		RUN	1376..1436	CDD:214736
Dennd4c	XP_006538085.1	uDENN	192..275	CDD:214824	18/76 (24%)
		DENN	308..491	CDD:366936	56/197 (28%)
		dDENN	558..631	CDD:129037	16/75 (21%)
		PPR repeat	819..848	CDD:276811	5/28 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2127
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3728
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.930