DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pns and dennd5b

DIOPT Version :9

Sequence 1:	NP_647620.1	Gene:	pns / 38178	FlyBaseID:	FBgn0035229	Length:	1449	Species:	Drosophila melanogaster
Sequence 2:	XP_005164768.1	Gene:	dennd5b / 323528	ZFINID:	ZDB-GENE-030131-2248	Length:	1325	Species:	Danio rerio

Alignment Length:	1470	Identity:	585/1470 - (39%)
Similarity:	806/1470 - (54%)	Gaps:	253/1470 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 RFADYFVICGLDLDTGLEPDRF--------------------AGDNLHCSPLDRAYKSKPLAHYP 115
            |||.||::||||.:||||||..                    ||:|...|||.|.:|||.|||||
Zfish    14 RFAHYFIVCGLDDETGLEPDALAALYQWLEADRQGKDPEATAAGENFDQSPLKRTFKSKVLAHYP 78

  Fly   116 ENVPWNPFDAHGICMLSLPQGLRFRTQKHCIEPRFHSFATTREDGKRCYGFSLVFYEEIRNRNIC 180
            ||:..||||...:.||.:|:||.||||:..:.|.||||..|||||.|.|||...||||:.:..||
Zfish    79 ENIECNPFDQDAVNMLCMPKGLSFRTQRDSLAPHFHSFLITREDGSRTYGFVHTFYEEVTSPQIC 143

  Fly   181 GAIHTLQSMFITE--------LSNGQQTHSLSRVKQDGPVSRSLPRHFKVAGQAPQSAQSYYDIN 237
            .|:.||..|...|        .|:...:.|.|.......:|.||......:....:.....||..
Zfish   144 SAMQTLHQMHQAEHNTSAQNCTSSSSSSSSSSSSSSMDSLSSSLDDVDSPSAHGGRRTCEGYDSI 208

  Fly   238 KDKLYVAKSITLICQAPYAFAAQMFLKNLYRCLPRQPGAGISLESYVYNILYEVMLPQPGKSIR- 301
            :|.|||:|::.||...|:..|.:.||..::|.:...|...:.||||:||:||||.||..|:|::
Zfish   209 RDTLYVSKAMCLIAPMPFMHACKRFLAQMHRAVSCSPPPPLPLESYIYNVLYEVPLPASGRSLKF 273

  Fly   302 --VYLPPTEPHLPPIALILQRPLLATELPLLDFPLRLLFKYLGVECVIQLLTCVLLENQVLLRST 364
              ||.|          ::.|||.:. ||||.||||...|:.||||.::||.||||||.|:||.|.
Zfish   274 HGVYEP----------ILCQRPGVG-ELPLADFPLADAFRLLGVENLVQLFTCVLLEMQILLYSQ 327

  Fly   365 DYQRLMIVGECITSLLFPFVWPHVYAPILPAALHHFLDAPVPFVMGLHAECEAAHK----IGSEA 425
            ||||||:|.|.||:|||||.|.|||.|||||:|.||||||||::|||.:: |...:    :..||
Zfish   328 DYQRLMVVAEGITTLLFPFQWQHVYVPILPASLLHFLDAPVPYLMGLQSK-EGTDRSKLELPQEA 391

  Fly   426 TLCFVDIDKKHIQLPEELPVFPHKVDFMAEIGSVLDKFEIERDRDQEPSFRNGYVGRGAGGGVSG 490
            .|||||||...|:|||:.|.||::.:|:.|:..||..|
Zfish   392 NLCFVDIDNHCIELPEDFPQFPNRSEFIQELSEVLLSF--------------------------- 429

  Fly   491 SGSSGSGGVDAMISSCTLPT--GLQAARRSKE-RFQQMQETV-YTLSGSPGGGVVDYQPLIAHPS 551
             |.|..||     ||...|.  .||.:...|| :...::|.| ...:|:.||..:|...|:....
Zfish   430 -GQSPEGG-----SSSPEPAVMSLQTSVLEKELKSTSLRELVDDKTNGNLGGEALDVLELLQGNP 488

  Fly   552 RIDHVPRIADFLRRKGGIRGAGSPVGSPTVSLSSSPVGIYHDVDAVDATMPVSTRRAEKQKLSPV 616
            .::.:..:|    ::.|::.|         .|.:...|...| :.|....||     |:::|
Zfish   489 TLERLQALA----KRTGVKVA---------RLEALAAGQKGD-EGVGGRSPV-----EEEEL--- 531

  Fly   617 DQYYQDLRINNSVREIFLNRFVHMFHAYEYFVIYPNQARDEWISNRETLQNFDKSSFLSDQPEHH 681
                ::.::|..:||:|..||..||..||.|||..:...:.|::|||.:.||||:||||||||.:
Zfish   532 ----RNAKLNVQLREVFAARFATMFADYESFVIQNSPDLESWLTNREQMHNFDKASFLSDQPEPY 592

  Fly   682 RAFLSRFLESQMFATLIDNKILAMWESQPDEQLQLFDQRVKLLRRRHGENMIAATS-----YEPC 741
            ..|||.|:|:|||||.|||||::.|| :.:..|::||.|::..|..:    :.|.|     |:.|
Zfish   593 LPFLSHFIETQMFATFIDNKIMSQWE-EKEPLLRVFDGRIEKARLYN----VRAPSLRSSVYQKC 652

  Fly   742 VLSQDSQQGFEKRLNCIDIEVTPPS--EILANRAAYFRS-FPLLEKGVL----------NQECAS 793
            ...::|.|..|:||..||.....|.  ::...:..|.:. ||.|:..||          |:.|::
Zfish   653 TFLKESAQAIEQRLRKIDHTAIHPHLLDMKIGQGKYQQGFFPKLQADVLASGPTSNKWSNRTCST 717

  Fly   794 RGNSLRRVKNGNKWRAREISLDQKPGSNAINRLSANL---TTADVSPALIAQANWTFVERLLKDI 855
            : ..:.|.:..|:....:..|.:|....|.| |..||   ..:|:|||:|||.||.|||.|||:.
Zfish   718 Q-RRVERHRQQNEHLVLDNELKEKYMQEARN-LGKNLRQPKLSDLSPAVIAQTNWKFVEGLLKEC 780

  Fly   856 KSKTKRMLLEKMGNEAVALGLKGD----GIEENTLIASMCDLLEKIWSHGLQNKQGKSALWAHLQ 916
            |.||||||:||||.|||.|| .|:    |:||||||||:|||||:|||||||.||||||||:||.
Zfish   781 KMKTKRMLVEKMGREAVELG-HGEANITGLEENTLIASLCDLLERIWSHGLQVKQGKSALWSHLL 844

  Fly   917 AYLEMQEARGAGDSSGTEQTPPVSSSPGGKMTIATASPALAWNAMRKRMDYLSTFQTDFDSPPSP 981
            .|...:|..                                              :...:||.|.
Zfish   845 HYQAREEKN----------------------------------------------EQQLESPVSN 863

  Fly   982 NRSRSRDRNKFVGLEQLCPLPESLEFDVKNVLAMADIKTHIGYTRAWVRLSLEKKLLSRHFRTLL 1046
            .:.| |.....|||.   .|..|:..|::::..||:|||.:|..|||:||||||||||:|.:.||
Zfish   864 GQER-RKTESSVGLP---GLRVSVIQDMRHIQNMAEIKTDVGRARAWIRLSLEKKLLSQHLKQLL 924

  Fly  1047 SDEALLRSLYKRSAFLRCEEEKEQFLYHLLTLNTVDYFSFTNIYPTTKLPYRVVIFPSRKYGSYH 1111
            |::||.:.||||.|||||||||||||:|||:||.||||.||:::.|..:|||.||.|.:|..:..
Zfish   925 SNQALTKKLYKRYAFLRCEEEKEQFLFHLLSLNAVDYFCFTSVFTTIMIPYRAVIIPIKKLSNAM 989

  Fly  1112 TSSNVWIMVSGTMNETQRVPVPKGSLEFIF--------HY------KNLGLLTTMRIGHDNSGPS 1162
            |:||.|:.|||.:.::..:.:.|..||..|        |.      :|||.|||:::||||||..
Zfish   990 TTSNPWLCVSGELGDSGILQITKNILEMTFDSAFRPHTHISIAFKCQNLGKLTTVQLGHDNSGLL 1054

  Fly  1163 HKWLVEQVVMRNEVTGHTYKFPCGRWLGRGVDDDSTERLLVGQRVLTNAKNAELVP------GSD 1221
            .||||:.|::|||:||||||||||||||:||||.|.||:|:|:.|         ||      |..
Zfish  1055 AKWLVDCVMVRNEITGHTYKFPCGRWLGKGVDDGSLERVLIGEFV---------VPCGDDEGGRG 1110

  Fly  1222 TRTPPRTRSPSVQRQETLA--------PS--EIQHQLGNCVNVLVKWHYKPSRDRDVGTLTNLLC 1276
            ::|||..||||..|:.::.        |:  :||..:|..||.::|..:||.::|  |:||.|||
Zfish  1111 SKTPPLQRSPSQIRRISITSLTGKGNKPTTVQIQESIGEAVNNIIKHFHKPEKER--GSLTVLLC 1173

  Fly  1277 GDDGLVKCLEQVFLCGFRSARFFGRNLYIWDYFTKIKELFEHNLQM-ELEDSSSSLDSSFSNGSG 1340
            |:.|||..|||.|..||||||.|.:|:::||:|.:|....|:..|. :|::|...|..:
Zfish  1174 GEGGLVWALEQFFHHGFRSARIFQKNVFVWDFFERIVAFMENRDQTGDLQESPEPLSLN------ 1232

  Fly  1341 SGGNSLQRREISSIWRLYVQLMDEINGTALGKDGKFQLLICLSLREHLLTRLIKPMALTKVTHEM 1405
              ..||.|         ||..::.:... :|||||||||:||..|:.||.:.:..:|.:.|...|
Zfish  1233 --SESLCR---------YVNAINNMPRN-IGKDGKFQLLVCLGARDRLLPQWLPLLAESPVITRM 1285

  Fly  1406 YEEESFLRRRNLLTFLIQILEPLDDCHIVLENSITQGIRI 1445
            |||.:.||.:..::.|:.:||.|.|..|.||.|:|:.:.:
Zfish  1286 YEENALLRDKLTVSSLLGVLETLHDFPITLETSLTKSVEL 1325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pns	NP_647620.1	uDENN	70..171	CDD:214824	59/119 (50%)
		DENN	243..435	CDD:214823	101/198 (51%)
		dDENN	626..701	CDD:129037	41/74 (55%)
		RUN	<989..1083	CDD:295434	54/93 (58%)
		PLAT_RAB6IP1	1095..1203	CDD:238855	60/121 (50%)
		RUN	1376..1436	CDD:214736	23/59 (39%)
dennd5b	XP_005164768.1	uDENN	12..134	CDD:214824	59/119 (50%)
		DENN	213..401	CDD:280329	102/199 (51%)
		dDENN	537..612	CDD:129037	41/74 (55%)
		RUN	817..961	CDD:295434	84/193 (44%)
		PLAT_RAB6IP1	973..1095	CDD:238855	60/121 (50%)
		RUN	1178..1319	CDD:280855	58/158 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	182	1.000	Domainoid score	I3396
eggNOG	1	0.900	-	-		E1_KOG2127
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H44911
Inparanoid	1	1.050	956	1.000	Inparanoid score	I319
OMA	1	1.010	-	-		QHG52593
OrthoDB	1	1.010	-	-		D35195at33208
OrthoFinder	1	1.000	-	-		FOG0003741
OrthoInspector	1	1.000	-	-		otm26576
orthoMCL	1	0.900	-	-		OOG6_104889
Panther	1	1.100	-	-	LDO	PTHR46070
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3728
SonicParanoid	1	1.000	-	-		X2599
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870