DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pns and Dennd4a

DIOPT Version :9

Sequence 1:	NP_647620.1	Gene:	pns / 38178	FlyBaseID:	FBgn0035229	Length:	1449	Species:	Drosophila melanogaster
Sequence 2:	XP_008764615.1	Gene:	Dennd4a / 315756	RGDID:	1562639	Length:	1873	Species:	Rattus norvegicus

Alignment Length:	1264	Identity:	244/1264 - (19%)
Similarity:	405/1264 - (32%)	Gaps:	472/1264 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 AYKSKPLAHY----------PENVPWNPFDAHGICMLSLPQGLRFR----TQKHCIEPRFHSFAT 155
            :||:..:..|          ||:||          :..||.|....    ..|:.: |.|.:|..
  Rat   207 SYKAGLICRYPQEDYESFSLPESVP----------LFCLPMGATIECWPPDSKYPL-PVFSTFVL 260

  Fly   156 TREDGKRCYGFSLVFYEEIRNRNICGAIHTLQSMFITELSNGQQTHSLSRVKQDGPVSRSLPRHF 220
            |....::.||.::.|||.....|:......|  :.:|.|.:|         |.||  ||:
  Rat   261 TGASAEKVYGAAIQFYEPYSEENLTEKQRLL--LGLTSLVDG---------KSDG--SRT----- 307

  Fly   221 KVAGQAPQSAQSYYDINKDKLYVAKSITLICQAPYAFAAQMFLKNLYRCLPRQPGAGISLESYVY 285
                                ::..|.|.|:...|:..|.:.||..|||.....|.| :.:|.::.
  Rat   308 --------------------IHTNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHA-LPIEKHIS 351

  Fly   286 NILYEVMLPQPGK-SIRVYLPPTEPHLPPIALILQRPLLATELPLLDFPLRLLFKYLGVECVIQL 349
            :.:::|..|.|.: .|.|.|.|.:      .|||.:| :::.|||.......|.:.||.|..:.|
  Rat   352 HFMHKVPFPSPQRPRILVQLSPHD------NLILSQP-VSSPLPLSGGKFSTLLQNLGPENAVTL 409

  Fly   350 LTCVLLENQVLLRSTDYQRLMIVGECITSLLFPFVWPHVYAPILPAALHHFLDAPVPFVMGLHAE 414
            |...:.|:::|:.|.....|..|.|.:.|::|||.||..|.|:.|.||...|.||.||::|
  Rat   410 LVFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFIVG---- 470

  Fly   415 CEAAHKIGSEATLCFVDIDKKHIQLPEELPVFPHKVDFMAEIGSV-LDKFEIERDRDQEPSFRNG 478
                             ||.::..|.:..|          ::..| ||...|.:..|::
  Rat   471 -----------------IDSRYFDLYDPPP----------DVSCVDLDTNTISQTGDKK------ 502

  Fly   479 YVGRGAGGGVSGSGSSGSGGVDAMISSCTLPTGLQAARRSKERFQQMQETVYTLSGSPGGGVVDY 543
                                   .::...||         |:..:.:..|::.|          :
  Rat   503 -----------------------NVAWKILP---------KKPCKNLMNTLHNL----------H 525

  Fly   544 QPLIAHPSRIDHVPRIADFLRRKGGIRGAGSPVGSPTVSLSSSPVGIYHDVDAVDATMPVSTRRA 608
            |.|    :::...||                                  |...:|..|......:
  Rat   526 QQL----AKLQQRPR----------------------------------DDGLMDLAMNDYDFNS 552

  Fly   609 EKQKLSPVDQYYQDLRINNSVREIFLNRFVHMFHAYEYFVIYPNQARDEWISNRETLQNFDKSSF 673
            .| :|..:|.         .::|.||.....:...|..::....:|..|..::..:|  |...:|
  Rat   553 GK-RLHMIDL---------EIQEAFLFFMASILKGYRSYLRPITEAPSETATDATSL--FALQAF 605

  Fly   674 LSDQPEHHRAFLSRFLESQMFATLIDNKILAMWESQPDEQLQLFDQRVKLLRRRHGENMIAATSY 738
            |..:...|:.|.:...::|||...|:.   ..:.|..|..|..||.
  Rat   606 LRSRDRSHQKFYNMMTKTQMFIRFIEE---CSFVSDKDASLAFFDD------------------- 648

  Fly   739 EPCVLSQDSQQGFEKRLNCID--------IEVTPPSEI--LANRAA-----YFRSFPLLEKGVLN 788
              ||...|:.:..|.||..:|        :.|||| ||  |.|...     .:..||:|
  Rat   649 --CVDKVDTDKSGEVRLIELDASFKSEHTVFVTPP-EIPQLPNGEEPPLQYSYNGFPVL------ 704

  Fly   789 QECASRGNSLRRVKNGNKWRAREISLDQKPGSNAINRLSANLTTADVSPALIAQANWTFVERLLK 853
                 |.|...|.:  ...:||:..|..||.|..             ||:       ....|..:
  Rat   705 -----RNNLFERPE--GFLQARKNKLPSKPSSPG-------------SPS-------PMFRRTKQ 742

  Fly   854 DIKSKTKRMLLEKMGNEAVALGLKGDGIEENTLIASMCDLLEKIWSHG-LQNKQGKSALW-AHLQ 916
            :|||..|                          ||.....:.::||.. |::..|   || ..|.
  Rat   743 EIKSAHK--------------------------IAKRYSSIPQMWSRCLLRHCYG---LWFICLP 778

  Fly   917 AYLEMQEARGAGDSSGTEQTPPVSSSPGGKMTIATASPALAWNAMRKRMDYLSTFQTDFDSPPSP 981
            ||:::..::                                ..|::...|.|...|.....||
  Rat   779 AYVKVCHSK--------------------------------VRALKTAYDVLKKMQLKKMDPP-- 809

  Fly   982 NRSRSRDRNKFVGLEQLC-----PL---------------PESLEFDVKNVLAMADI---KTHIG 1023
                  |...:..|.|||     |:               |.::.:...|...:...   ::..|
  Rat   810 ------DEVCYRILMQLCGQYDQPVLAVRVLFEMQKAGIDPNAITYGYYNKAVLESTWPSRSRSG 868

  Fly  1024 YTRAWVRL-------SLEKKLLSRH----------FRTLLSDEALLRSLYKRSAF----LRCEEE 1067
            |. .|.::       :..|:.|.:|          .|:.|...:|.:...:|.|.    ::.|::
  Rat   869 YF-LWTKIRNVVLGVAQFKRALKKHPHLPQTALSGGRSDLGYSSLCKDDVRREATSTEDIQGEKD 932

  Fly  1068 KEQFLYHLLTLN-----TVDYFSFTNIYPTTKLPYRVVIFPSRKYGSYHTSSNVWIMVSGT---- 1123
            |:......|:.|     :.|                  ..||.   ||.:||.: :.:|||
  Rat   933 KKGSDSSSLSENESAKGSAD------------------CLPSL---SYQSSSTI-VRLSGTNQDG 975

  Fly  1124 -----------------------MNETQRVPVPKGSLEFIFHYKNLGLLTTMRIGHDNSGPSHKW 1165
                                   .||.|.:|                 ....|..|.:...||
  Rat   976 ADKMSGECEESTPELLLVPSCNDTNEAQTMP-----------------SRCFRKRHKSDDESH-- 1021

  Fly  1166 LVEQVVM----RNEVTGHTYKFPCGRWLGRGVDDDSTERLLVGQRVLTNAKNAELVPGS-DTRTP 1225
            |.:|:..    ||...|...:|...|........|..|:|....::|:|..:....|.| |...|
  Rat  1022 LQQQMPWGNRNRNLSGGVLMRFMLNRINQETNPGDMVEKLGADAKILSNVISKSTRPNSLDIGKP 1086

  Fly  1226 P-RTRSPSVQRQETLAPSEIQHQLGNCVN 1253
            | |::..|::::.  :..:......||::
  Rat  1087 PVRSKRDSLEKES--SDDDTPFDASNCLD 1113

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pns	NP_647620.1	uDENN	70..171	CDD:214824	17/79 (22%)
		DENN	243..435	CDD:214823	58/192 (30%)
		dDENN	626..701	CDD:129037	16/74 (22%)
		RUN	<989..1083	CDD:295434	22/142 (15%)
		PLAT_RAB6IP1	1095..1203	CDD:238855	27/138 (20%)
		RUN	1376..1436	CDD:214736
Dennd4a	XP_008764615.1	uDENN	194..276	CDD:214824	17/79 (22%)
		DENN	309..493	CDD:396629	63/222 (28%)
		dDENN	560..633	CDD:129037	17/86 (20%)
		PPR_2	809..849	CDD:404055	8/47 (17%)
		PPR repeat	811..840	CDD:276811	5/28 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2127
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810