DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment pns and Dennd3

DIOPT Version :9

Sequence 1:NP_647620.1 Gene:pns / 38178 FlyBaseID:FBgn0035229 Length:1449 Species:Drosophila melanogaster
Sequence 2:XP_235398.7 Gene:Dennd3 / 315055 RGDID:1311559 Length:1278 Species:Rattus norvegicus


Alignment Length:1390 Identity:257/1390 - (18%)
Similarity:445/1390 - (32%) Gaps:491/1390 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   104 RAYKSKPLAHYPENVPW--NPFDAH-----------GICMLSLPQ-----GLRFRTQKHCI--EP 148
            |:::.|  ...|....|  :|.|:.           |:.:|:|||     |:       |:  ||
  Rat    80 RSFRKK--REKPRMESWKSHPGDSKGPDSEDVTIPGGVDLLALPQLCFPGGV-------CVASEP 135

  Fly   149 R---FHSFATTREDGKRCYGFSLVFYEEIRNRNICGAIHTLQSMFITELSNGQQTHSLSRVKQDG 210
            :   .|....|...|.|.||....:|..:.:          :..|....|:.:.:.|.:|     
  Rat   136 KEDYIHFLVLTDVCGNRTYGVVAQYYRPLHD----------EYCFYNGKSHWEPSMSSAR----- 185

  Fly   211 PVSRSLPRHFKVAGQAPQSAQSYYDINKDKLYVAKSITLICQAPYA------FAAQMFLKNLYRC 269
               |.:|....|..:.|     ||:..||.|....:...:|:....      |||::.|      
  Rat   186 ---RFVPFAVCVVSRFP-----YYNSLKDCLSCLLTHLKLCKDFEVDNHIKDFAARLSL------ 236

  Fly   270 LPRQPGAGISLESYVYNILYEVMLPQPGKSIRVYLPP-TEPHLPPIALILQRPLLATELPLLDFP 333
            :|..|...:.|   ::|:          |.::|..|. .:|..|.|.|.|..|||.         
  Rat   237 IPSPPPGPLHL---IFNM----------KPLQVVFPSRADPESPIIDLDLHLPLLC--------- 279

  Fly   334 LRLLFKYLGVECVIQLLTCVLLENQVLLRSTDYQRLMIVGECITSLLFPFVWPHVYAPILPAALH 398
                |:   .|.|:|:|||:|.|.:::..|:|:..|.::.||..:.:.|..|.|.:.|||...:.
  Rat   280 ----FR---PEKVLQILTCILTEQRMVFFSSDWALLTLMAECFVAYVHPLQWQHTFVPILSGQML 337

  Fly   399 HFLDAPVPFVMGLHAECEAAH--KIGSEAT-LCFVDID----------KKHIQLPEELPVFPHKV 450
            .|:.||..|:||.|.:    |  ::..||. |..:|||          .:.:.:| ::|:...:.
  Rat   338 DFVMAPTSFLMGCHLD----HFEEVRKEADGLVLIDIDLGSVTCSKSSDEDVDIP-DVPLLLAQA 397

  Fly   451 DFMAEIGSV-------LDKFEIERDRDQEPSFRNGY----------------VG----------- 481
             |:..:.|:       |.......|.::..:.|..:                ||           
  Rat   398 -FIQRVQSLQLHPDLHLAHLSASTDLNEGRARRRAWQQALNCKIQHITLQLLVGIFREVKNHLNY 461

  Fly   482 -------------RGAGGGV------------SGSGSSGSGGVDAMISSCTLPTGLQAARRSKER 521
                         |.||...            |...:..:|.:|| .:...|.|..:..|..:..
  Rat   462 EHRVFNSEEFLKTRAAGDQQFYKQVLDTYMFHSFLKARLNGRMDA-FARMDLDTQSEEDRIDRML 525

  Fly   522 FQQMQETVYTLSGSPGGGVVDYQPL-IAHPSRIDHVPRIADFLRRKGGIRGAGSPVGSPTVSLSS 585
            ....:.||..::....      .|| |||...:..:|.:.|....:...|.:...:...:...||
  Rat   526 ISPRRPTVEKMASRKA------SPLNIAHRRMVVSMPNLQDISLPELPPRNSSLRIMDTSSCKSS 584

  Fly   586 SPVGIYHDVDAVDATMPVSTRRAEKQKLSP---------VDQYYQDLRINNS------------- 628
            |||            :.|:.:.....|:..         |..|:.||....|             
  Rat   585 SPV------------LKVTPKSTYTFKIPEIHFPLVSQCVQAYFTDLVTLLSKAMALLGPGDSLL 637

  Fly   629 -VREIFLNRFVHMFHA------YEYFVIYPNQARDEWISNRETLQNFDKSSFLSDQPEHHRAFLS 686
             .|..:|...:|:...      .::..:|....|   |...:.::....|...|::.:..|....
  Rat   638 LARYFYLRGLIHLMQGQLLNALLDFQSLYKTDIR---IFPADLVKGMVDSMSASERAQAERTPEL 699

  Fly   687 RFLESQMF-----ATLIDNKILAMWESQPDEQLQLFDQRVKLLRRRHGENMIAATS-----YEPC 741
            |.|.:::|     |..:|:.:...  ..|.:.:||.|    .::|.....::..|:     ::..
  Rat   700 RRLITEVFDKQGEAPKVDDAVKNF--ELPKKHMQLND----FVKRVQESGIVKDTTIIHRLFDAL 758

  Fly   742 VLSQDSQQGFEKRLNCIDIEVTPPSEILANRAAYFRSFPLLEKGVLNQECASRGNSLRRVKNGNK 806
            .:..:.|         ||.|.             ||.|         ..|               
  Rat   759 TVGHEKQ---------IDPET-------------FRDF---------YTC--------------- 777

  Fly   807 WR-----AREISL-----DQKPGSNAINRLSANLTT---------ADVSPALIAQANWTFVE--- 849
            |:     |:|:||     |....:..:.:||:::.|         ......|:.:...::||   
  Rat   778 WKETEAEAQEVSLPALLVDHLDRNECVYKLSSSVKTNRGVGKIAMTQKRLFLLPEGRPSYVEIAT 842

  Fly   850 -RLLKDIKSKTKRMLLEKMGNEAVALGLKGDGIEENTLIASMCDL----LEKIWSHGLQNKQGKS 909
             |.::::||.|...||.|:....:....|.:..|.|  :.|.|||    ::::|:       ||.
  Rat   843 FRNIEEVKSTTVAFLLLKIPTLKIKTVAKKEVFEAN--LKSECDLWHLMVKEMWA-------GKK 898

  Fly   910 ALWAH---------LQAYLEMQEARGAGDSSG-------------------------TEQTPPVS 940
            ....|         |...|.|....|...|||                         |.:|....
  Rat   899 LADDHKDPQYVQQALTNVLLMDAVVGTLQSSGAIYAASKLAYFDKMKNELPMAVPKTTSETLKHK 963

  Fly   941 SSPGGKMTIATASPALAWNAMRKRMDYLSTFQTDFDSPPSPNRSRSRDRNKFVGLEQLCPLPES- 1004
            .:|....|...|...|.:                     :|.|....::.:....:..|.|.|. 
  Rat   964 INPSAGETAPQAIEVLLY---------------------TPGRLDPAEKVEDAHPKLWCALNEGK 1007

  Fly  1005 -LEFDVK----------------NVLAMADIKTHIGYTRAWV-------------RLSLEKKLLS 1039
             :.||..                |.:.||:      :::.||             .:|..|:|..
  Rat  1008 VVVFDASSWTIHQHCFKVGSSKVNCMVMAE------HSQVWVGSEDSVIYIINVHSMSCNKQLTD 1066

  Fly  1040 RHFRTLLSDEALLRSLYKRSAFLRCEEEKEQFLYHLLTLNTVDYFSFTN------------IYPT 1092
            .  |:.::..| :.|..|.||...|..:.....:::.||..:..|...:            ::..
  Rat  1067 H--RSAVTGLA-VPSGKKPSAVYSCSLDGTVLAWNVSTLRVISRFQLQHGDLMSISLHNDRVFCC 1128

  Fly  1093 TKLPYRVV-----------IFPSRKYGSYHTS-------SNVWIMVSGTMNETQRVPVPKGSLEF 1139
            |.....||           |.||.:..:...:       ..:|:..:|.            |..:
  Rat  1129 TARSILVVTLQGFVRQELRIQPSEEPSASFLAIQLLPEEQQLWVACTGV------------SELY 1181

  Fly  1140 IFHYKNLGLLTTMRIGHDNSGPSHKWLVEQVVMRNEVTGHTYKFPC------GRWL-GRGVDDDS 1197
            |:..|:||            .|..|..::..   .|||       |      ..|: |||:....
  Rat  1182 IWSLKDLG------------QPPQKTHLQDC---TEVT-------CMIRVKRQIWVGGRGLSQGK 1224

  Fly  1198 TERLLVGQRVLTNAKNAELVPGSDT 1222
            |...:....|.......|||..|||
  Rat  1225 TRGKIYVMDVEKVTLEKELVAHSDT 1249

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pnsNP_647620.1 uDENN 70..171 CDD:214824 21/89 (24%)
DENN 243..435 CDD:214823 54/211 (26%)
dDENN 626..701 CDD:129037 15/99 (15%)
RUN <989..1083 CDD:295434 22/124 (18%)
PLAT_RAB6IP1 1095..1203 CDD:238855 23/132 (17%)
RUN 1376..1436 CDD:214736
Dennd3XP_235398.7 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2127
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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