Protein Alignment pns and Dennd5a

DIOPT Version :10

• Sequence 1: NP_647620.1
• Gene: pns / 38178
• FlyBaseID: FBgn0035229
• Length: 1449
• Species: Drosophila melanogaster
• Sequence 2: NP_001101016.2
• Gene: Dennd5a / 308942
• RGDID: 1306759
• Length: 1287
• Species: Rattus norvegicus
• Alignment Length: 1506
• Identity: 588/1506 - (39%)
• Similarity: 813/1506 - (53%)
• Gaps: 301/1506 - (19%)

  Fly    21 SGNGSGNGSGPNIQVAPSSTLVQSPTSPGEQSQSQSELNQLKRDADPQFSRFADYFVICGLDLDT 85
            ||.|.|.||.|                                      |||||||||||||.:|
  Rat     2 SGGGGGGGSAP--------------------------------------SRFADYFVICGLDTET 28

  Fly    86 GLEPDRFA------------------------GDNLHCSPLDRAYKSKPLAHYPENVPWNPFDAH 126
            |||||..:                        |:|...:||.|.:|||.||.|||||.|||||..
  Rat    29 GLEPDELSALCQYIQASKARDGASPFISSTTEGENFEQTPLRRTFKSKVLARYPENVDWNPFDQD 93

  Fly   127 GICMLSLPQGLRFRTQKHCIEPRFHSFATTREDGKRCYGFSLVFYEEIRNRNICGAIHTLQSMFI 191
            .:.||.:|:||.|:||....||:||:|..|||||.|.:||:|.||||:.::.||.|:.||..|..
  Rat    94 AVGMLCMPKGLAFKTQADPREPQFHAFIITREDGSRTFGFALTFYEEVTSKQICSAMQTLYHMHN 158

  Fly   192 TE-------LSNGQQTHSLSRVKQDGPVSRSLPRHFKVAGQAPQSAQSYYDINKDKLYVAKSITL 249
            .|       |::|.....:    :||   ..:|      |...|...| |||::|.|||:|.|.|
  Rat   159 AEYDVLHAPLADGGDQSGM----EDG---EGIP------GTKLQRFNS-YDISRDTLYVSKCICL 209

  Fly   250 ICQAPYAFAAQMFLKNLYRCLPRQPGAGISLESYVYNILYEVMLPQPGKSIR---VYLPPTEPHL 311
            |....:..|.:..|:.|::.:.......:.||||:||:||||.||.||:|::   ||.|
  Rat   210 ITPMSFMKACRSVLQQLHQAVTSPQPPPLPLESYIYNVLYEVPLPPPGRSLKFSGVYGP------ 268

  Fly   312 PPIALILQRPLLATELPLLDFPLRLLFKYLGVECVIQLLTCVLLENQVLLRSTDYQRLMIVGECI 376
                :|.||| ...||||.|||::.:|:.||||.|.||.||.|||.|:||.|..|||||.|.|.|
  Rat   269 ----IICQRP-STNELPLFDFPVKEVFELLGVENVFQLFTCALLEFQILLYSQHYQRLMTVAETI 328

  Fly   377 TSLLFPFVWPHVYAPILPAALHHFLDAPVPFVMGLHA---ECEAAHKIGSEATLCFVDIDKKHIQ 438
            |:|:|||.|.|||.|||||:|.||||||||::||||:   :..:..::..||.|||||:|...|:
  Rat   329 TALMFPFQWQHVYVPILPASLLHFLDAPVPYLMGLHSNGLDDRSKLELPQEANLCFVDVDNHFIE 393

  Fly   439 LPEELPVFPHKVDFMAEIGSVLDKFEIERDRDQEPSFRNGYVGRGAGGGVSGSGSSGSGGVDAMI 503
            |||:||.||:|::|:.|:..:|..|                       ||...|:
  Rat   394 LPEDLPQFPNKLEFVQEVSEILMAF-----------------------GVPPEGN---------- 425

  Fly   504 SSCTLPTGLQAARRSKERFQQM--QETVYTLSGSPGGGVVDYQPLIAHPSRIDHVPRIADFLRRK 566
                |.....|::..:.|..::  .:....::|||   :..|:.|    ...:.:.|:...::|.
  Rat   426 ----LHCSESASKLKRIRASELVSDKKNGNIAGSP---LHSYELL----KENETIARLQALVKRT 479

  Fly   567 GGIRGAGSPVGSPTVSLSSSPVGIYHDVDAVDATMPVSTR----RAEKQKLSPVDQYYQDLRINN 627
            |             |||..  :.:..|        |.|.:    :.::::|    :.||   :|.
  Rat   480 G-------------VSLEK--LEVRED--------PSSNKDFKVQCDEEEL----RIYQ---LNI 514

  Fly   628 SVREIFLNRFVHMFHAYEYFVIYPNQARDEWISNRETLQNFDKSSFLSDQPEHHRAFLSRFLESQ 692
            .:||:|.|||..||..||.|||.|:|.::.|:||||.:|||||:||||||||.:..|||||||:|
  Rat   515 QIREVFANRFTQMFADYEVFVIQPSQDKESWLSNREQMQNFDKASFLSDQPEPYLPFLSRFLETQ 579

  Fly   693 MFATLIDNKILAMWESQPDEQLQLFDQRVKLLRRRHGENMIAATS-YEPCVLSQDSQQGFEKRLN 756
            |||:.|||||:...:...|..|::||.||..:|..:.......|| |:.|....::::..|.||.
  Rat   580 MFASFIDNKIMCHDDDDKDPVLRVFDSRVDKIRLLNVRTPTLRTSMYQKCTTVDEAEKAIELRLA 644

  Fly   757 CIDIEVTPPS--EILANRAAYFRS-FPLLEKGVLNQECASRGNSLR------RVKNGNKWRAREI 812
            .||.....|.  ::...:..|... ||.|:..||....||...:.|      |.|:..|.....:
  Rat   645 KIDHTAVHPHLLDMKIGQGKYEPGFFPKLQSDVLCTGPASNKWTKRNAPAQWRRKDRQKQHTEHL 709

  Fly   813 SLDQKPGSNAINRLSANLTT-------ADVSPALIAQANWTFVERLLKDIKSKTKRMLLEKMGNE 870
            .||.......|.. :.|:.:       :::||::|||.||.|||.|||:.::||||||:||||.|
  Rat   710 RLDNDQREKYIQE-ARNMGSTIRQPKLSNLSPSVIAQTNWKFVEGLLKECRNKTKRMLVEKMGRE 773

  Fly   871 AVALGLKGD----GIEENTLIASMCDLLEKIWSHGLQNKQGKSALWAHLQAYLEMQEARGAGDSS 931
            ||.|| .|:    |:||||||||:|||||:|||||||.||||||||:||   |..||.|....:|
  Rat   774 AVELG-HGEVNITGVEENTLIASLCDLLERIWSHGLQVKQGKSALWSHL---LHYQENRQRKLTS 834

  Fly   932 GTEQTPPVSSSPGGKMTIATASPALAWNAMRKRMDYLSTFQTDFDSPPSPNRSRSRDRNKFVGLE 996
            |:                                  |||.....||          :|.|.....
  Rat   835 GS----------------------------------LSTSGILLDS----------ERRKSDASA 855

  Fly   997 QLCPLPESLEFDVKNVLAMADIKTHIGYTRAWVRLSLEKKLLSRHFRTLLSDEALLRSLYKRSAF 1061
            .:.||..||..|::::..:.:|||.:|..|||||||:||||||||.:.||||..|.:.||||.||
  Rat   856 VMSPLRVSLIQDMRHIQNIGEIKTDVGKARAWVRLSMEKKLLSRHLKQLLSDHELTKKLYKRYAF 920

  Fly  1062 LRCEEEKEQFLYHLLTLNTVDYFSFTNIYPTTKLPYRVVIFPSRKYGSYHTSSNVWIMVSGTMNE 1126
            |||::||||||||||:.|.||||.|||::.|..:||.::|.||:|.|....::|.||.:||.:.|
  Rat   921 LRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIPYHILIVPSKKLGGSMFTANPWICISGELGE 985

  Fly  1127 TQRVPVPKGSLEFIFHYKNLGLLTTMRIGHDNSGPSHKWLVEQVVMRNEVTGHTYKFPCGRWLGR 1191
            ||.:.:|:..||..|..:|||.|||::|||||||...|||||.|::|||:||||||||||||||:
  Rat   986 TQILQIPRNVLEMTFECQNLGKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGK 1050

  Fly  1192 GVDDDSTERLLVGQRVLTNAKNAELVPGSDTRTPPRTRSPSV-QRQETLAPS--------EIQHQ 1247
            |:||.|.||:|||: :||:....:..|   .||||..:|||| :|..|::|:        :||..
  Rat  1051 GMDDGSLERVLVGE-LLTSLPEVDERP---CRTPPLQQSPSVIRRLVTISPNNKPKLNTGQIQES 1111

  Fly  1248 LGNCVNVLVKWHYKPSRDRDVGTLTNLLCGDDGLVKCLEQVFLCGFRSARFFGRNLYIWDYFTKI 1312
            :|..||.:||..:||.::|  |:||.||||:.|||..|||.|..||:|.|.| :|::|||:..|.
  Rat  1112 IGEAVNGIVKHFHKPEKER--GSLTLLLCGECGLVSALEQAFQHGFKSPRLF-KNVFIWDFLEKA 1173

  Fly  1313 KELFEHNLQMELEDSSSSLDSSFSNGSGSGGNSLQRREI--SSIW----RLYVQLMDEINGTA-- 1369
            :..:|                           :|::.::  ...|    |.:.:.:..:|.|.
  Rat  1174 QTYYE---------------------------TLEQNDVVPEENWHTRARNFCRFVTAVNNTPRN 1211

  Fly  1370 LGKDGKFQLLICLSLREHLLTRLIKPMALTKVTHEMYEEESFLRRRNLLTFLIQILEPLDDCHIV 1434
            :|||||||:|:||..|:|||...|..:|...:|..|||:.:.::...|:..||::|:.|.:.:|.
  Rat  1212 IGKDGKFQMLVCLGARDHLLHHWIALLADCPITAHMYEDVALIKDHTLVNSLIRVLQTLQEFNIT 1276

  Fly  1435 LENSITQGIRI 1445
            |:.|:.:||.|
  Rat  1277 LDTSLVKGIDI 1287

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pns	NP_647620.1	uDENN	70..171	CDD:214824	61/124 (49%)
		DENN	243..435	CDD:214823	97/197 (49%)
		dDENN	626..701	CDD:129037	47/74 (64%)
		RUN1_DENND5	839..1091	CDD:439039	127/255 (50%)
		PLAT_RAB6IP1	1095..1203	CDD:238855	61/107 (57%)
		RUN2_DENND5	1243..1440	CDD:439040	68/204 (33%)
Dennd5a	NP_001101016.2	uDENN	12..138	CDD:214824	62/163 (38%)
		DENN	202..390	CDD:460461	98/198 (49%)
		dDENN	513..588	CDD:129037	47/74 (64%)
		RUN1_DENND5A	742..950	CDD:439052	127/255 (50%)
		PLAT_RAB6IP1	954..1062	CDD:238855	61/107 (57%)
		RUN2_DENND5A	1107..1282	CDD:439054	68/204 (33%)