DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pns and Sbf1

DIOPT Version :9

Sequence 1:	NP_647620.1	Gene:	pns / 38178	FlyBaseID:	FBgn0035229	Length:	1449	Species:	Drosophila melanogaster
Sequence 2:	XP_038934802.1	Gene:	Sbf1 / 300147	RGDID:	1307090	Length:	1950	Species:	Rattus norvegicus

Alignment Length:	1402	Identity:	270/1402 - (19%)
Similarity:	451/1402 - (32%)	Gaps:	438/1402 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 QSPTSPGEQSQSQSELNQLKR---DADPQFSRFADYFVICGLDLDTGLEPDRFAGDNLHCSPLDR 104
            |:|.:||....    |.:.:|   .|.||.|. .....:|.|...:|.|.......:       |
  Rat    18 QAPEAPGRAGW----LGRWRRKPWSAAPQRSG-PGVSQVCSLGPASGHERAAIESSS-------R 70

  Fly   105 AYKSKPLAHYPENVP---WNPFDAHGICMLSLPQGLRFRTQKHCIEPRFHSFATTREDGKRCYGF 166
            ..:.:||........   |........|.   |.|.:...:::  .|.|.....|..:.:|.|..
  Rat    71 GARLRPLPWRGSRTTSCWWRSGRTRAFCQ---PSGWQLCPERN--PPTFFVAVLTDINSERHYCA 130

  Fly   167 SLVFYEEIRNRNICGAIHTLQSMFITE--LSNGQQTHSLSRVKQDGPVSRSLPRHFKVAGQAPQS 229
            .|.|:|         .:.:.|.:..||  ....::.|.                    .|||..|
  Rat   131 CLTFWE---------PVESTQEVMCTEDATEKEEEAHG--------------------GGQAQLS 166

  Fly   230 AQSYYDINKDKLYVAKSITLICQAPYAFAAQMFLKNLYRCLPRQPGAGISLESYVYNILYEVMLP 294
            :.:  .....:|:..|::.|:.:..:|...:..|..:|..  ...|..::||:.:.|:| ...:|
  Rat   167 STA--PAQPGQLFAPKTLVLVSRLDHADVFRNSLGLIYTI--HVEGLNVNLENVIGNLL-TCTVP 226

  Fly   295 QPGKSIRVYLPPTEPHLPPIAL------ILQRPLLATELPLLDFPLRLLFKYLGVECVIQLLTCV 353
            ..|.|   .|...|.....|:|      ::|.||: ..||:....:.|||:.||:..|:.|....
  Rat   227 LAGGS---QLDSVEEGARTISLGAGDRQVIQTPLV-DSLPVSRCSVALLFRQLGITNVLSLFCAA 287

  Fly   354 LLENQVLLRSTDYQRLMIVGECITSLLFPFVWPHVYAPILPAALHHFLDAPVPFVMGLHAECEAA 418
            |.|::||..|..||||......:.:||||..:...|.|||||.|...|..|.||::|::|.
  Rat   288 LTEHKVLFLSRSYQRLADACRGLLALLFPLRYSFTYVPILPAQLLEVLSTPTPFIIGVNAA---- 348

  Fly   419 HKIGSEATLCFVDIDKKHIQLPEELPVFPHKVDFMAEIGSVLDKFEIERDRDQEPSFRNGYVGRG 483
                                             |.||...:||....:.|
  Rat   349 ---------------------------------FQAETQELLDVIVADLD--------------- 365

  Fly   484 AGGGVSGSGSSGSGGVDAMISSCTLPTGLQAARRSKERFQQMQETVYTLSGSPGGGVVDYQPLIA 548
             ||.|:             :..|.
  Rat   366 -GGTVT-------------VPECV----------------------------------------- 375

  Fly   549 HPSRIDHVPRIADFLRRKGGIRGAGSPVGSPT---VSLSSSPVGIYHDVDAVDATMPVSTRRAEK 610
                  |:|.:.:             |:.|.|   :|:...|     :::..|...|..|..|..
  Rat   376 ------HIPPLPE-------------PLQSQTHNVLSMVLDP-----ELELADLAFPPPTTSASS 416

  Fly   611 QKLSPVDQYYQDLRINNSVREIFLNRFVHMFHAYEYFV----IYPNQARDEWISNRETLQNFDKS 671
            .|:       ||    ..:|.:||..|..:...|.:.:    |:|           |.:..|.|:
  Rat   417 LKM-------QD----KELRAVFLRLFAQLLQGYRWCLHIVRIHP-----------EPVIRFHKA 459

  Fly   672 SFLSDQPEHHRAFLSRFLESQMFATLIDNKILAMWESQPDEQLQLFDQRV--KLLRRRHGEN--- 731
            :||..:......||.:.||...||..:..:      ..|.....|||:.|  ::.|.|..||
  Rat   460 AFLGQRGLVEDDFLMKVLEGMAFAGFVSER------GVPYRSTDLFDELVAHEVARMRADENHPH 518

  Fly   732 -------MIAATSYE-----PCVLSQDSQQGFEKRLNCIDIEVTPPSEILANRAAYFRSFPLLEK 784
                   .:|...|:     |.|.....|:               |.|....|..: |.||.|::
  Rat   519 RVLRHVQELAEQLYKNENPYPAVAMHKVQR---------------PGEASHLRRTH-RPFPRLDE 567

  Fly   785 G----VLNQECASRGNSLRRVKNGNKWRAREISLDQKPGSNAI-NRLSA-NLTTADVSPALIAQA 843
            |    :::|..|....:...||     ..|..::...|...|| .|.|. ::.:|.....:....
  Rat   568 GTVQWIVDQAAAKMQGAPPAVK-----AERRTTVPSGPPMTAILERCSGPHINSARRLEVVRNCI 627

  Fly   844 NWTFVERLLKDIKSKTKRMLLEKMGNEAVALGLKGDGIEENTLIASMCDLLEKIWSHGLQNKQGK 908
            ::.|..::|     :.|::|      .||...|||..       |..| |..::..|..||:
  Rat   628 SYVFEGKML-----EAKKLL------PAVLRALKGRA-------ARRC-LAHELHLHVQQNR--- 670

  Fly   909 SALWAHLQAYLE-------MQEARGAGDSSGTEQT--PPVSS-----SPGGKMT----------I 949
             |:..|.|....       :|:.... |..|....  |.|::     |||  :|          :
  Rat   671 -AVLDHQQFDFVVRMMNCCLQDCTSL-DEHGIAAALLPLVTAFCRKLSPG--VTQFAYSCVQEHV 731

  Fly   950 ATASPALAWNAMRKRMDYLSTFQTDFDS---PPSPNRSRSRDRNKFVGLEQLCPLPESLEFDVKN 1011
            ..::|.. |.||     :....||...:   .||...|.:::..:           ...:.|.::
  Rat   732 VWSTPQF-WEAM-----FYGDVQTHIRALYLEPSDGVSPTQETGE-----------AQSQDDERS 779

  Fly  1012 VLAMADIKTHIGYTRAWVRLSLEK--KLLSRHFRTLLSDEALLRSLYKRSAFLRCEEEKEQFLYH 1074
            .|.:|..:     .|.|..||.||  :|:.:...|:.| :|:..:.......|..:..|.:.|..
  Rat   780 ALDVASEQ-----RRLWPTLSREKQQELVQKEESTVFS-QAIHYANRMSYLLLPLDSSKSRLLRE 838

  Fly  1075 LLTLNTVDYFSFTNIYPTTKLPYRVVIFPSRKYGSYHTSSNVWIMVSGTMNETQRVPVPKGSLEF 1139
            ...|.  |..|.:|...|..:...|.       .||.|.|.        ..:.:...|....:.|
  Rat   839 RAGLG--DLESASNSLVTNSMAGSVA-------ESYDTESG--------FEDAETCDVAGAVVRF 886

  Fly  1140 IFHYKNLGLLTTMRIGHDNSGPSHKWLVEQVVMRNEVTGHTYKFPCGRWLGRGVDDDSTERLLVG 1204
            |..:                       |::|...:.||....|         |:      .::|.
  Rat   887 INRF-----------------------VDKVCTESGVTSDHLK---------GL------HVMVP 913

  Fly  1205 QRVLTNAKNAELVPGSDTRTPPRTRSPSVQRQETLAPSEIQHQLGNCVNVLVKWHYKP-SRDRDV 1268
            ..|..:.:..|.|.....|.||      :|:.:.|.|..:..:  .||...::.:..| .|:..|
  Rat   914 DIVQMHIETLEAVHRESKRLPP------IQKPKLLRPRLLPGE--ECVLDGLRVYLLPDGREEGV 970

  Fly  1269 GTLTN---LLCGDDGLVKCLEQVFLCGFRSARFFGRNLYIWDY-------------FTKIKELFE 1317
            |....   ||..:..:.....:|...|..:....|..:.:..:             .|.:.:|.:
  Rat   971 GGSGGGPALLPAEGAVFLTTYRVIFTGMPTDPLVGEQVVVRSFPVAALTKEKRISVQTPVDQLLQ 1035

  Fly  1318 HNLQMELEDSSSSLDSSFSNGSGSGGNSLQRREISSI 1354
            ..||:. ..:...|..:|....||....|.|:::..:
  Rat  1036 DGLQLR-SCTFQLLKMAFDEEVGSDSAELFRKQLHKL 1071

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pns	NP_647620.1	uDENN	70..171	CDD:214824	18/103 (17%)
		DENN	243..435	CDD:214823	55/197 (28%)
		dDENN	626..701	CDD:129037	18/78 (23%)
		RUN	<989..1083	CDD:295434	17/95 (18%)
		PLAT_RAB6IP1	1095..1203	CDD:238855	14/107 (13%)
		RUN	1376..1436	CDD:214736
Sbf1	XP_038934802.1	uDENN	<97..132	CDD:397495	8/39 (21%)
		DENN	178..367	CDD:214823	61/248 (25%)
		dDENN	421..489	CDD:129037	19/82 (23%)
		SBF2	600..821	CDD:403522	55/269 (20%)
		PH-like	950..1068	CDD:418428	21/120 (18%)
		PTP_DSP_cys	1207..1579	CDD:421693
		PH_Sbf1_hMTMR5	1843..1948	CDD:269941
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2127
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900