Protein Alignment pns and DENND5A

DIOPT Version :10

• Sequence 1: NP_647620.1
• Gene: pns / 38178
• FlyBaseID: FBgn0035229
• Length: 1449
• Species: Drosophila melanogaster
• Sequence 2: NP_056028.2
• Gene: DENND5A / 23258
• HGNCID: 19344
• Length: 1287
• Species: Homo sapiens
• Alignment Length: 1506
• Identity: 592/1506 - (39%)
• Similarity: 808/1506 - (53%)
• Gaps: 301/1506 - (19%)

  Fly    21 SGNGSGNGSGPNIQVAPSSTLVQSPTSPGEQSQSQSELNQLKRDADPQFSRFADYFVICGLDLDT 85
            ||.|.|.||.|                                      |||||||||||||.:|
Human     2 SGGGGGGGSAP--------------------------------------SRFADYFVICGLDTET 28

  Fly    86 GLEPDRFA------------------------GDNLHCSPLDRAYKSKPLAHYPENVPWNPFDAH 126
            |||||..:                        |:|...:||.|.:|||.||.|||||.|||||..
Human    29 GLEPDELSALCQYIQASKARDGASPFISSTTEGENFEQTPLRRTFKSKVLARYPENVEWNPFDQD 93

  Fly   127 GICMLSLPQGLRFRTQKHCIEPRFHSFATTREDGKRCYGFSLVFYEEIRNRNICGAIHTLQSMFI 191
            .:.||.:|:||.|:||....||:||:|..|||||.|.:||:|.||||:.::.||.|:.||..|..
Human    94 AVGMLCMPKGLAFKTQADPREPQFHAFIITREDGSRTFGFALTFYEEVTSKQICSAMQTLYHMHN 158

  Fly   192 TELS------NGQQTHSLSRVKQDGPVSRSLPRHFKVAGQAPQSAQSYYDINKDKLYVAKSITLI 250
            .|..      ...:..|.....:|.||:: |.|.            :.|||::|.|||:|.|.||
Human   159 AEYDVLHAPPADDRDQSSMEDGEDTPVTK-LQRF------------NSYDISRDTLYVSKCICLI 210

  Fly   251 CQAPYAFAAQMFLKNLYRCLPRQPGAGISLESYVYNILYEVMLPQPGKSIR---VYLPPTEPHLP 312
            ....:..|.:..|:.|::.:.......:.||||:||:||||.||.||:|::   ||.|
Human   211 TPMSFMKACRSVLEQLHQAVTSPQPPPLPLESYIYNVLYEVPLPPPGRSLKFSGVYGP------- 268

  Fly   313 PIALILQRPLLATELPLLDFPLRLLFKYLGVECVIQLLTCVLLENQVLLRSTDYQRLMIVGECIT 377
               :|.||| ...||||.|||::.:|:.||||.|.||.||.|||.|:||.|..|||||.|.|.||
Human   269 ---IICQRP-STNELPLFDFPVKEVFELLGVENVFQLFTCALLEFQILLYSQHYQRLMTVAETIT 329

  Fly   378 SLLFPFVWPHVYAPILPAALHHFLDAPVPFVMGLHA---ECEAAHKIGSEATLCFVDIDKKHIQL 439
            :|:|||.|.|||.|||||:|.||||||||::||||:   :..:..::..||.|||||||...|:|
Human   330 ALMFPFQWQHVYVPILPASLLHFLDAPVPYLMGLHSNGLDDRSKLELPQEANLCFVDIDNHFIEL 394

  Fly   440 PEELPVFPHKVDFMAEIGSVLDKFEIERDRDQEPSFRNGYVGRGAGGGVSGSGSSGSGGVDAMIS 504
            ||:||.||:|::|:.|:..:|..|.|..:                 |.:..|.|:
Human   395 PEDLPQFPNKLEFVQEVSEILMAFGIPPE-----------------GNLHCSESA---------- 432

  Fly   505 SCTLPTGLQAARRSKERFQQMQETVY-----TLSGSPGGGVVDYQPLIAHPSRIDHVPRIADFLR 564
                         ||.:..:..|.|.     .::|||   :..|:.|    ...:.:.|:...::
Human   433 -------------SKLKRLRASELVSDKRNGNIAGSP---LHSYELL----KENETIARLQALVK 477

  Fly   565 RKGGIRGAGSPVGSPTVSLSSSPVGIYHDVDAVDATMPVSTRRAEKQKLSPVDQYYQDLRI---N 626
            |.|             |||..  :.:..|        |.|.:..:.|    .|:  ::|||   |
Human   478 RTG-------------VSLEK--LEVRED--------PSSNKDLKVQ----CDE--EELRIYQLN 513

  Fly   627 NSVREIFLNRFVHMFHAYEYFVIYPNQARDEWISNRETLQNFDKSSFLSDQPEHHRAFLSRFLES 691
            ..:||:|.|||..||..||.|||.|:|.::.|.:|||.:|||||:||||||||.:..|||||||:
Human   514 IQIREVFANRFTQMFADYEVFVIQPSQDKESWFTNREQMQNFDKASFLSDQPEPYLPFLSRFLET 578

  Fly   692 QMFATLIDNKILAMWESQPDEQLQLFDQRVKLLRRRHGENMIAATS-YEPCVLSQDSQQGFEKRL 755
            ||||:.|||||:...:...|..|::||.||..:|..:.......|| |:.|....::::..|.||
Human   579 QMFASFIDNKIMCHDDDDKDPVLRVFDSRVDKIRLLNVRTPTLRTSMYQKCTTVDEAEKAIELRL 643

  Fly   756 NCIDIEVTPPS--EILANRAAYFRS-FPLLEKGVLNQECASRGNSLR------RVKNGNKWRARE 811
            ..||.....|.  ::...:..|... ||.|:..||:...||...:.|      |.|:..|.....
Human   644 AKIDHTAIHPHLLDMKIGQGKYEPGFFPKLQSDVLSTGPASNKWTKRNAPAQWRRKDRQKQHTEH 708

  Fly   812 ISLDQKPGSNAINRLSANLTT------ADVSPALIAQANWTFVERLLKDIKSKTKRMLLEKMGNE 870
            :.||.......|.......:|      :::||::|||.||.|||.|||:.::||||||:||||.|
Human   709 LRLDNDQREKYIQEARTMGSTIRQPKLSNLSPSVIAQTNWKFVEGLLKECRNKTKRMLVEKMGRE 773

  Fly   871 AVALGLKGD----GIEENTLIASMCDLLEKIWSHGLQNKQGKSALWAHLQAYLEMQEARGAGDSS 931
            ||.|| .|:    |:||||||||:|||||:|||||||.||||||||:||   |..|:.|....:|
Human   774 AVELG-HGEVNITGVEENTLIASLCDLLERIWSHGLQVKQGKSALWSHL---LHYQDNRQRKLTS 834

  Fly   932 GTEQTPPVSSSPGGKMTIATASPALAWNAMRKRMDYLSTFQTDFDSPPSPNRSRSRDRNKFVGLE 996
            |:                                  |||.....||          :|.|.....
Human   835 GS----------------------------------LSTSGILLDS----------ERRKSDASS 855

  Fly   997 QLCPLPESLEFDVKNVLAMADIKTHIGYTRAWVRLSLEKKLLSRHFRTLLSDEALLRSLYKRSAF 1061
            .:.||..||..|::::..:.:|||.:|..|||||||:||||||||.:.||||..|.:.||||.||
Human   856 LMPPLRISLIQDMRHIQNIGEIKTDVGKARAWVRLSMEKKLLSRHLKQLLSDHELTKKLYKRYAF 920

  Fly  1062 LRCEEEKEQFLYHLLTLNTVDYFSFTNIYPTTKLPYRVVIFPSRKYGSYHTSSNVWIMVSGTMNE 1126
            |||::||||||||||:.|.||||.|||::.|..:||.::|.||:|.|....::|.||.:||.:.|
Human   921 LRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIPYHILIVPSKKLGGSMFTANPWICISGELGE 985

  Fly  1127 TQRVPVPKGSLEFIFHYKNLGLLTTMRIGHDNSGPSHKWLVEQVVMRNEVTGHTYKFPCGRWLGR 1191
            ||.:.:|:..||..|..:|||.|||::|||||||...|||||.|::|||:||||||||||||||:
Human   986 TQIMQIPRNVLEMTFECQNLGKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGK 1050

  Fly  1192 GVDDDSTERLLVGQRVLTNAKNAELVPGSDTRTPPRTRSPSV-QRQETLAPS--------EIQHQ 1247
            |:||.|.||:|||: :||:....:..|   .||||..:|||| :|..|::|:        :||..
Human  1051 GMDDGSLERILVGE-LLTSQPEVDERP---CRTPPLQQSPSVIRRLVTISPNNKPKLNTGQIQES 1111

  Fly  1248 LGNCVNVLVKWHYKPSRDRDVGTLTNLLCGDDGLVKCLEQVFLCGFRSARFFGRNLYIWDYFTKI 1312
            :|..||.:||..:||.::|  |:||.||||:.|||..|||.|..||:|.|.| :|::|||:..|.
Human  1112 IGEAVNGIVKHFHKPEKER--GSLTLLLCGECGLVSALEQAFQHGFKSPRLF-KNVFIWDFLEKA 1173

  Fly  1313 KELFEHNLQMELEDSSSSLDSSFSNGSGSGGNSLQRREI--SSIW----RLYVQLMDEINGTA-- 1369
            :..:|                           :|::.|:  ...|    |.:.:.:..||.|.
Human  1174 QTYYE---------------------------TLEKNEVVPEENWHTRARNFCRFVTAINNTPRN 1211

  Fly  1370 LGKDGKFQLLICLSLREHLLTRLIKPMALTKVTHEMYEEESFLRRRNLLTFLIQILEPLDDCHIV 1434
            :|||||||:|:||..|:|||...|..:|...:|..|||:.:.::...|:..||::|:.|.:.:|.
Human  1212 IGKDGKFQMLVCLGARDHLLHHWIALLADCPITAHMYEDVALIKDHTLVNSLIRVLQTLQEFNIT 1276

  Fly  1435 LENSITQGIRI 1445
            ||.|:.:||.|
Human  1277 LETSLVKGIDI 1287

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pns	NP_647620.1	uDENN	70..171	CDD:214824	61/124 (49%)
		DENN	243..435	CDD:214823	98/197 (50%)
		dDENN	626..701	CDD:129037	46/74 (62%)
		RUN1_DENND5	839..1091	CDD:439039	126/255 (49%)
		PLAT_RAB6IP1	1095..1203	CDD:238855	61/107 (57%)
		RUN2_DENND5	1243..1440	CDD:439040	71/204 (35%)
DENND5A	NP_056028.2	uDENN	12..138	CDD:214824	62/163 (38%)
		DENN	202..390	CDD:460461	99/198 (50%)
		dDENN	513..588	CDD:129037	46/74 (62%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	681..709		6/27 (22%)
		RUN1_DENND5A	742..950	CDD:439052	126/255 (49%)
		PLAT_RAB6IP1	954..1062	CDD:238855	61/107 (57%)
		RUN2_DENND5A	1107..1282	CDD:439054	71/204 (35%)