DRSC/TRiP Functional Genomics Resources

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Protein Alignment pns and DENND5A

DIOPT Version :9

Sequence 1:NP_647620.1 Gene:pns / 38178 FlyBaseID:FBgn0035229 Length:1449 Species:Drosophila melanogaster
Sequence 2:NP_056028.2 Gene:DENND5A / 23258 HGNCID:19344 Length:1287 Species:Homo sapiens


Alignment Length:1506 Identity:592/1506 - (39%)
Similarity:808/1506 - (53%) Gaps:301/1506 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 SGNGSGNGSGPNIQVAPSSTLVQSPTSPGEQSQSQSELNQLKRDADPQFSRFADYFVICGLDLDT 85
            ||.|.|.||.|                                      |||||||||||||.:|
Human     2 SGGGGGGGSAP--------------------------------------SRFADYFVICGLDTET 28

  Fly    86 GLEPDRFA------------------------GDNLHCSPLDRAYKSKPLAHYPENVPWNPFDAH 126
            |||||..:                        |:|...:||.|.:|||.||.|||||.|||||..
Human    29 GLEPDELSALCQYIQASKARDGASPFISSTTEGENFEQTPLRRTFKSKVLARYPENVEWNPFDQD 93

  Fly   127 GICMLSLPQGLRFRTQKHCIEPRFHSFATTREDGKRCYGFSLVFYEEIRNRNICGAIHTLQSMFI 191
            .:.||.:|:||.|:||....||:||:|..|||||.|.:||:|.||||:.::.||.|:.||..|..
Human    94 AVGMLCMPKGLAFKTQADPREPQFHAFIITREDGSRTFGFALTFYEEVTSKQICSAMQTLYHMHN 158

  Fly   192 TELS------NGQQTHSLSRVKQDGPVSRSLPRHFKVAGQAPQSAQSYYDINKDKLYVAKSITLI 250
            .|..      ...:..|.....:|.||:: |.|.            :.|||::|.|||:|.|.||
Human   159 AEYDVLHAPPADDRDQSSMEDGEDTPVTK-LQRF------------NSYDISRDTLYVSKCICLI 210

  Fly   251 CQAPYAFAAQMFLKNLYRCLPRQPGAGISLESYVYNILYEVMLPQPGKSIR---VYLPPTEPHLP 312
            ....:..|.:..|:.|::.:.......:.||||:||:||||.||.||:|::   ||.|       
Human   211 TPMSFMKACRSVLEQLHQAVTSPQPPPLPLESYIYNVLYEVPLPPPGRSLKFSGVYGP------- 268

  Fly   313 PIALILQRPLLATELPLLDFPLRLLFKYLGVECVIQLLTCVLLENQVLLRSTDYQRLMIVGECIT 377
               :|.||| ...||||.|||::.:|:.||||.|.||.||.|||.|:||.|..|||||.|.|.||
Human   269 ---IICQRP-STNELPLFDFPVKEVFELLGVENVFQLFTCALLEFQILLYSQHYQRLMTVAETIT 329

  Fly   378 SLLFPFVWPHVYAPILPAALHHFLDAPVPFVMGLHA---ECEAAHKIGSEATLCFVDIDKKHIQL 439
            :|:|||.|.|||.|||||:|.||||||||::||||:   :..:..::..||.|||||||...|:|
Human   330 ALMFPFQWQHVYVPILPASLLHFLDAPVPYLMGLHSNGLDDRSKLELPQEANLCFVDIDNHFIEL 394

  Fly   440 PEELPVFPHKVDFMAEIGSVLDKFEIERDRDQEPSFRNGYVGRGAGGGVSGSGSSGSGGVDAMIS 504
            ||:||.||:|::|:.|:..:|..|.|..:                 |.:..|.|:          
Human   395 PEDLPQFPNKLEFVQEVSEILMAFGIPPE-----------------GNLHCSESA---------- 432

  Fly   505 SCTLPTGLQAARRSKERFQQMQETVY-----TLSGSPGGGVVDYQPLIAHPSRIDHVPRIADFLR 564
                         ||.:..:..|.|.     .::|||   :..|:.|    ...:.:.|:...::
Human   433 -------------SKLKRLRASELVSDKRNGNIAGSP---LHSYELL----KENETIARLQALVK 477

  Fly   565 RKGGIRGAGSPVGSPTVSLSSSPVGIYHDVDAVDATMPVSTRRAEKQKLSPVDQYYQDLRI---N 626
            |.|             |||..  :.:..|        |.|.:..:.|    .|:  ::|||   |
Human   478 RTG-------------VSLEK--LEVRED--------PSSNKDLKVQ----CDE--EELRIYQLN 513

  Fly   627 NSVREIFLNRFVHMFHAYEYFVIYPNQARDEWISNRETLQNFDKSSFLSDQPEHHRAFLSRFLES 691
            ..:||:|.|||..||..||.|||.|:|.::.|.:|||.:|||||:||||||||.:..|||||||:
Human   514 IQIREVFANRFTQMFADYEVFVIQPSQDKESWFTNREQMQNFDKASFLSDQPEPYLPFLSRFLET 578

  Fly   692 QMFATLIDNKILAMWESQPDEQLQLFDQRVKLLRRRHGENMIAATS-YEPCVLSQDSQQGFEKRL 755
            ||||:.|||||:...:...|..|::||.||..:|..:.......|| |:.|....::::..|.||
Human   579 QMFASFIDNKIMCHDDDDKDPVLRVFDSRVDKIRLLNVRTPTLRTSMYQKCTTVDEAEKAIELRL 643

  Fly   756 NCIDIEVTPPS--EILANRAAYFRS-FPLLEKGVLNQECASRGNSLR------RVKNGNKWRARE 811
            ..||.....|.  ::...:..|... ||.|:..||:...||...:.|      |.|:..|.....
Human   644 AKIDHTAIHPHLLDMKIGQGKYEPGFFPKLQSDVLSTGPASNKWTKRNAPAQWRRKDRQKQHTEH 708

  Fly   812 ISLDQKPGSNAINRLSANLTT------ADVSPALIAQANWTFVERLLKDIKSKTKRMLLEKMGNE 870
            :.||.......|.......:|      :::||::|||.||.|||.|||:.::||||||:||||.|
Human   709 LRLDNDQREKYIQEARTMGSTIRQPKLSNLSPSVIAQTNWKFVEGLLKECRNKTKRMLVEKMGRE 773

  Fly   871 AVALGLKGD----GIEENTLIASMCDLLEKIWSHGLQNKQGKSALWAHLQAYLEMQEARGAGDSS 931
            ||.|| .|:    |:||||||||:|||||:|||||||.||||||||:||   |..|:.|....:|
Human   774 AVELG-HGEVNITGVEENTLIASLCDLLERIWSHGLQVKQGKSALWSHL---LHYQDNRQRKLTS 834

  Fly   932 GTEQTPPVSSSPGGKMTIATASPALAWNAMRKRMDYLSTFQTDFDSPPSPNRSRSRDRNKFVGLE 996
            |:                                  |||.....||          :|.|.....
Human   835 GS----------------------------------LSTSGILLDS----------ERRKSDASS 855

  Fly   997 QLCPLPESLEFDVKNVLAMADIKTHIGYTRAWVRLSLEKKLLSRHFRTLLSDEALLRSLYKRSAF 1061
            .:.||..||..|::::..:.:|||.:|..|||||||:||||||||.:.||||..|.:.||||.||
Human   856 LMPPLRISLIQDMRHIQNIGEIKTDVGKARAWVRLSMEKKLLSRHLKQLLSDHELTKKLYKRYAF 920

  Fly  1062 LRCEEEKEQFLYHLLTLNTVDYFSFTNIYPTTKLPYRVVIFPSRKYGSYHTSSNVWIMVSGTMNE 1126
            |||::||||||||||:.|.||||.|||::.|..:||.::|.||:|.|....::|.||.:||.:.|
Human   921 LRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIPYHILIVPSKKLGGSMFTANPWICISGELGE 985

  Fly  1127 TQRVPVPKGSLEFIFHYKNLGLLTTMRIGHDNSGPSHKWLVEQVVMRNEVTGHTYKFPCGRWLGR 1191
            ||.:.:|:..||..|..:|||.|||::|||||||...|||||.|::|||:||||||||||||||:
Human   986 TQIMQIPRNVLEMTFECQNLGKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGK 1050

  Fly  1192 GVDDDSTERLLVGQRVLTNAKNAELVPGSDTRTPPRTRSPSV-QRQETLAPS--------EIQHQ 1247
            |:||.|.||:|||: :||:....:..|   .||||..:|||| :|..|::|:        :||..
Human  1051 GMDDGSLERILVGE-LLTSQPEVDERP---CRTPPLQQSPSVIRRLVTISPNNKPKLNTGQIQES 1111

  Fly  1248 LGNCVNVLVKWHYKPSRDRDVGTLTNLLCGDDGLVKCLEQVFLCGFRSARFFGRNLYIWDYFTKI 1312
            :|..||.:||..:||.::|  |:||.||||:.|||..|||.|..||:|.|.| :|::|||:..|.
Human  1112 IGEAVNGIVKHFHKPEKER--GSLTLLLCGECGLVSALEQAFQHGFKSPRLF-KNVFIWDFLEKA 1173

  Fly  1313 KELFEHNLQMELEDSSSSLDSSFSNGSGSGGNSLQRREI--SSIW----RLYVQLMDEINGTA-- 1369
            :..:|                           :|::.|:  ...|    |.:.:.:..||.|.  
Human  1174 QTYYE---------------------------TLEKNEVVPEENWHTRARNFCRFVTAINNTPRN 1211

  Fly  1370 LGKDGKFQLLICLSLREHLLTRLIKPMALTKVTHEMYEEESFLRRRNLLTFLIQILEPLDDCHIV 1434
            :|||||||:|:||..|:|||...|..:|...:|..|||:.:.::...|:..||::|:.|.:.:|.
Human  1212 IGKDGKFQMLVCLGARDHLLHHWIALLADCPITAHMYEDVALIKDHTLVNSLIRVLQTLQEFNIT 1276

  Fly  1435 LENSITQGIRI 1445
            ||.|:.:||.|
Human  1277 LETSLVKGIDI 1287

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pnsNP_647620.1 uDENN 70..171 CDD:214824 61/124 (49%)
DENN 243..435 CDD:214823 98/197 (50%)
dDENN 626..701 CDD:129037 46/74 (62%)
RUN <989..1083 CDD:295434 52/93 (56%)
PLAT_RAB6IP1 1095..1203 CDD:238855 61/107 (57%)
RUN 1376..1436 CDD:214736 21/59 (36%)
DENND5ANP_056028.2 uDENN 12..138 CDD:214824 62/163 (38%)
DENN 202..390 CDD:307995 99/198 (50%)
dDENN 513..588 CDD:129037 46/74 (62%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 681..709 6/27 (22%)
RUN 795..942 CDD:322053 85/193 (44%)
PLAT_RAB6IP1 954..1062 CDD:238855 61/107 (57%)
RUN 1143..1277 CDD:322053 50/161 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 183 1.000 Domainoid score I3434
eggNOG 1 0.900 - - E1_KOG2127
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 963 1.000 Inparanoid score I327
Isobase 1 0.950 - 0 Normalized mean entropy S5844
OMA 1 1.010 - - QHG52593
OrthoDB 1 1.010 - - D35195at33208
OrthoFinder 1 1.000 - - FOG0003741
OrthoInspector 1 1.000 - - otm40523
orthoMCL 1 0.900 - - OOG6_104889
Panther 1 1.100 - - O PTHR46070
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3728
SonicParanoid 1 1.000 - - X2599
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.820

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