Protein Alignment pns and DENND3

DIOPT Version :10

• Sequence 1: NP_647620.1
• Gene: pns / 38178
• FlyBaseID: FBgn0035229
• Length: 1449
• Species: Drosophila melanogaster
• Sequence 2: NP_001349727.1
• Gene: DENND3 / 22898
• HGNCID: 29134
• Length: 1296
• Species: Homo sapiens
• Alignment Length: 1052
• Identity: 202/1052 - (19%)
• Similarity: 335/1052 - (31%)
• Gaps: 393/1052 - (37%)

  Fly    50 EQSQSQSELNQLKRDADPQ-FSRFADYFVICGLDLDTGLEPDRFAGDNLHCSPLD----RAYKSK 109
            ||...:..:..|....||: .|.|...|:        ..|..:.||.|  |..|.    |:.:.|
Human    33 EQVAYKKGVKHLSALLDPEVLSIFVPPFI--------SKEDSQMAGAN--CGTLGKTRMRSLRKK 87

  Fly   110 ---------------PLAHYPEN--VPWNPFDAHGICMLSLPQ-----GLRFRTQ--KHCIEPRF 150
                           |.|..||:  ||      .|:.:|:|||     |:...|:  :.|:
Human    88 REKPRPEQWKGLPGPPRAPEPEDVAVP------GGVDLLTLPQLCFPGGVCVATEPKEDCV---- 142

  Fly   151 HSFATTREDGKRCYGFSLVFYEEIRNRNICGAIHTLQSMFITELSNGQQTHSLSRVKQDGPVSRS 215
            |....|...|.|.||....:|..:.: ..|             ..|| :||            |.
Human   143 HFLVLTDVCGNRTYGVVAQYYRPLHD-EYC-------------FYNG-KTH------------RE 180

  Fly   216 LPRHFKVAGQAPQSAQSYYDINKDKLYVAKSITLICQAPYA------FAAQMFLKNLYRCLPRQP 274
            .|..|........|...||:..||.|....::...|:....      |||::.|      :|..|
Human   181 CPGCFVPFAVCVVSRFPYYNSLKDCLSCLLALLKPCKDFEVDSHIKDFAAKLSL------IPSPP 239

  Fly   275 GAGISLESYVYNILYEVMLPQPGKSIRVYLPP-TEPHLPPIALILQRPLLATELPLLDFPLRLLF 338
            ...:.|   |:|:          ||:::.||. .:|                |.|:||..|.|..
Human   240 PGPLHL---VFNM----------KSLQIVLPARADP----------------ESPILDLDLHLPL 275

  Fly   339 KYLGVECVIQLLTCVLLENQVLLRSTDYQRLMIVGECITSLLFPFVWPHVYAPILPAALHHFLDA 403
            .....|.|:|:|||:|.|.:::..|:|:..|.:|.||..:.|:|..|.|.:.|||...:..|:.|
Human   276 LCFRPEKVLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQHPFVPILSDQMLDFVMA 340

  Fly   404 PVPFVMG---------------------------------------------------------L 411
            |..|:||                                                         |
Human   341 PTSFLMGCHLDHFEEVSKEADGLVLINIDHGSITYSKSTDDNVDIPDVPLLAAQTFIQRVQSLQL 405

  Fly   412 HAECEAAHKIGS----------------------EATL-----CFVDIDKKHIQLPEELPVFPHK 449
            |.|..|||.:.|                      :.||     .|.|: |.|:.       :.|:
Human   406 HHELHAAHLLSSTDLKEGRAHRRSWQQKLNCQIQQTTLQLLVSIFRDV-KNHLN-------YEHR 462

  Fly   450 VDFMAE-------------IGSVLDKFEIERDRDQEPSFRNGYVGR--GAGGGVSGSGSSGSGGV 499
            | |.:|             ...|||.:...       ||....:.|  .|...:.....|....:
Human   463 V-FNSEEFLKTRAPGDHQFYKQVLDTYMFH-------SFLKARLNRRMDAFAQMDLDTQSEEDRI 519

  Fly   500 DAMISSCTLPTGLQAARRSKERFQQMQETVYTLSGSPGGGVVDYQPLIAHPSRIDHVPRIADF-- 562
            :.|:.|...||..:.|.|......                       :.|...:..:|.:.|.
Human   520 NGMLLSPRRPTVEKRASRKSSHLH-----------------------VTHRRMVVSMPNLQDIAM 561

  Fly   563 -----------LRRKGGIRGAGSPVG----SPTV--------SLSSSPVGIYHDVDAVDATMPVS 604
                       |....|.||:.:.:.    ||..        .|.|..|..||
Human   562 PELAPRNSSLRLTDTAGCRGSSAVLNVTPKSPYTFKIPEIHFPLESKCVQAYH------------ 614

  Fly   605 TRRAEKQKLSPVDQYYQDLRINNSV---REIFLNRFVHMF------------HAYEYFV-IYP-- 651
                 ...:|.:.:....|..:||:   |.::|...|::.            :.|:..: |:|
Human   615 -----AHFVSMLSEAMCFLAPDNSLLLARYLYLRGLVYLMQGQLLNALLDFQNLYKTDIRIFPTD 674

  Fly   652 -------NQARDEWISNRETLQNFDKSSFLSDQPEHHRAFLSRFLESQMFATLIDNKILAMWESQ 709
                   :.:..||....:.             ||..| .:|..|:....|:.:|:.:...  ..
Human   675 LVKRTVESMSAPEWEGAEQA-------------PELMR-LISEILDKPHEASKLDDHVKKF--KL 723

  Fly   710 PDEQLQLFDQRVKLLRRRHGENMIAATS-----YEPCVLSQDSQ---QGFEKRLNCIDIEVTPPS 766
            |.:.:||.|    .::|.....::...|     :|...:.|:.|   :.|:...||.........
Human   724 PKKHMQLGD----FMKRVQESGIVKDASIIHRLFEALTVGQEKQIDPETFKDFYNCWKETEAEAQ 784

  Fly   767 EILANRAAYFRSFPLLEKGVLNQ-ECASRGNSLRRVKNGNKWRAREISLDQKPGSNAINRLSANL 830
            |:         |.|.|....|:: ||..:.:|..:...|    ..:|::.||       ||
Human   785 EV---------SLPWLVMEHLDKNECVCKLSSSVKTNLG----VGKIAMTQK-------RL---- 825

  Fly   831 TTADVSPALIAQANWTFVE----RLLKDIKSKTKRMLLEKMGNEAVALGLKGDGIEENTLIASMC 891
                   .|:.:....::|    |.:::::..|...||.::....:.:..|.:..|.|  :.:.|
Human   826 -------FLLTEGRPGYLEISTFRNIEEVRRTTTTFLLRRIPTLKIRVASKKEVFEAN--LKTEC 881

  Fly   892 DL----LEKIWS 899
            ||    ::::|:
Human   882 DLWHLMVKEMWA 893

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pns	NP_647620.1	uDENN	70..171	CDD:214824	31/128 (24%)
		DENN	243..435	CDD:214823	59/282 (21%)
		dDENN	626..701	CDD:129037	17/99 (17%)
		RUN1_DENND5	839..1091	CDD:439039	13/69 (19%)
		PLAT_RAB6IP1	1095..1203	CDD:238855
		RUN2_DENND5	1243..1440	CDD:439040
DENND3	NP_001349727.1	uDENN	108..158	CDD:470944	17/59 (29%)
		DENN	185..371	CDD:460461	55/220 (25%)
		dDENN	435..497	CDD:129037	15/77 (19%)
		WD40	1019..>1120	CDD:475233
		WD40 repeat	1028..1063	CDD:293791
		WD40 repeat	1067..1108	CDD:293791
		WD40 repeat	1114..1152	CDD:293791
		WD40 repeat	1160..1196	CDD:293791