DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment pns and DENND3

DIOPT Version :9

Sequence 1:NP_647620.1 Gene:pns / 38178 FlyBaseID:FBgn0035229 Length:1449 Species:Drosophila melanogaster
Sequence 2:NP_001349727.1 Gene:DENND3 / 22898 HGNCID:29134 Length:1296 Species:Homo sapiens


Alignment Length:1052 Identity:202/1052 - (19%)
Similarity:335/1052 - (31%) Gaps:393/1052 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    50 EQSQSQSELNQLKRDADPQ-FSRFADYFVICGLDLDTGLEPDRFAGDNLHCSPLD----RAYKSK 109
            ||...:..:..|....||: .|.|...|:        ..|..:.||.|  |..|.    |:.:.|
Human    33 EQVAYKKGVKHLSALLDPEVLSIFVPPFI--------SKEDSQMAGAN--CGTLGKTRMRSLRKK 87

  Fly   110 ---------------PLAHYPEN--VPWNPFDAHGICMLSLPQ-----GLRFRTQ--KHCIEPRF 150
                           |.|..||:  ||      .|:.:|:|||     |:...|:  :.|:    
Human    88 REKPRPEQWKGLPGPPRAPEPEDVAVP------GGVDLLTLPQLCFPGGVCVATEPKEDCV---- 142

  Fly   151 HSFATTREDGKRCYGFSLVFYEEIRNRNICGAIHTLQSMFITELSNGQQTHSLSRVKQDGPVSRS 215
            |....|...|.|.||....:|..:.: ..|             ..|| :||            |.
Human   143 HFLVLTDVCGNRTYGVVAQYYRPLHD-EYC-------------FYNG-KTH------------RE 180

  Fly   216 LPRHFKVAGQAPQSAQSYYDINKDKLYVAKSITLICQAPYA------FAAQMFLKNLYRCLPRQP 274
            .|..|........|...||:..||.|....::...|:....      |||::.|      :|..|
Human   181 CPGCFVPFAVCVVSRFPYYNSLKDCLSCLLALLKPCKDFEVDSHIKDFAAKLSL------IPSPP 239

  Fly   275 GAGISLESYVYNILYEVMLPQPGKSIRVYLPP-TEPHLPPIALILQRPLLATELPLLDFPLRLLF 338
            ...:.|   |:|:          ||:::.||. .:|                |.|:||..|.|..
Human   240 PGPLHL---VFNM----------KSLQIVLPARADP----------------ESPILDLDLHLPL 275

  Fly   339 KYLGVECVIQLLTCVLLENQVLLRSTDYQRLMIVGECITSLLFPFVWPHVYAPILPAALHHFLDA 403
            .....|.|:|:|||:|.|.:::..|:|:..|.:|.||..:.|:|..|.|.:.|||...:..|:.|
Human   276 LCFRPEKVLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQHPFVPILSDQMLDFVMA 340

  Fly   404 PVPFVMG---------------------------------------------------------L 411
            |..|:||                                                         |
Human   341 PTSFLMGCHLDHFEEVSKEADGLVLINIDHGSITYSKSTDDNVDIPDVPLLAAQTFIQRVQSLQL 405

  Fly   412 HAECEAAHKIGS----------------------EATL-----CFVDIDKKHIQLPEELPVFPHK 449
            |.|..|||.:.|                      :.||     .|.|: |.|:.       :.|:
Human   406 HHELHAAHLLSSTDLKEGRAHRRSWQQKLNCQIQQTTLQLLVSIFRDV-KNHLN-------YEHR 462

  Fly   450 VDFMAE-------------IGSVLDKFEIERDRDQEPSFRNGYVGR--GAGGGVSGSGSSGSGGV 499
            | |.:|             ...|||.:...       ||....:.|  .|...:.....|....:
Human   463 V-FNSEEFLKTRAPGDHQFYKQVLDTYMFH-------SFLKARLNRRMDAFAQMDLDTQSEEDRI 519

  Fly   500 DAMISSCTLPTGLQAARRSKERFQQMQETVYTLSGSPGGGVVDYQPLIAHPSRIDHVPRIADF-- 562
            :.|:.|...||..:.|.|......                       :.|...:..:|.:.|.  
Human   520 NGMLLSPRRPTVEKRASRKSSHLH-----------------------VTHRRMVVSMPNLQDIAM 561

  Fly   563 -----------LRRKGGIRGAGSPVG----SPTV--------SLSSSPVGIYHDVDAVDATMPVS 604
                       |....|.||:.:.:.    ||..        .|.|..|..||            
Human   562 PELAPRNSSLRLTDTAGCRGSSAVLNVTPKSPYTFKIPEIHFPLESKCVQAYH------------ 614

  Fly   605 TRRAEKQKLSPVDQYYQDLRINNSV---REIFLNRFVHMF------------HAYEYFV-IYP-- 651
                 ...:|.:.:....|..:||:   |.::|...|::.            :.|:..: |:|  
Human   615 -----AHFVSMLSEAMCFLAPDNSLLLARYLYLRGLVYLMQGQLLNALLDFQNLYKTDIRIFPTD 674

  Fly   652 -------NQARDEWISNRETLQNFDKSSFLSDQPEHHRAFLSRFLESQMFATLIDNKILAMWESQ 709
                   :.:..||....:.             ||..| .:|..|:....|:.:|:.:...  ..
Human   675 LVKRTVESMSAPEWEGAEQA-------------PELMR-LISEILDKPHEASKLDDHVKKF--KL 723

  Fly   710 PDEQLQLFDQRVKLLRRRHGENMIAATS-----YEPCVLSQDSQ---QGFEKRLNCIDIEVTPPS 766
            |.:.:||.|    .::|.....::...|     :|...:.|:.|   :.|:...||.........
Human   724 PKKHMQLGD----FMKRVQESGIVKDASIIHRLFEALTVGQEKQIDPETFKDFYNCWKETEAEAQ 784

  Fly   767 EILANRAAYFRSFPLLEKGVLNQ-ECASRGNSLRRVKNGNKWRAREISLDQKPGSNAINRLSANL 830
            |:         |.|.|....|:: ||..:.:|..:...|    ..:|::.||       ||    
Human   785 EV---------SLPWLVMEHLDKNECVCKLSSSVKTNLG----VGKIAMTQK-------RL---- 825

  Fly   831 TTADVSPALIAQANWTFVE----RLLKDIKSKTKRMLLEKMGNEAVALGLKGDGIEENTLIASMC 891
                   .|:.:....::|    |.:::::..|...||.::....:.:..|.:..|.|  :.:.|
Human   826 -------FLLTEGRPGYLEISTFRNIEEVRRTTTTFLLRRIPTLKIRVASKKEVFEAN--LKTEC 881

  Fly   892 DL----LEKIWS 899
            ||    ::::|:
Human   882 DLWHLMVKEMWA 893

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pnsNP_647620.1 uDENN 70..171 CDD:214824 31/128 (24%)
DENN 243..435 CDD:214823 59/282 (21%)
dDENN 626..701 CDD:129037 17/99 (17%)
RUN <989..1083 CDD:295434
PLAT_RAB6IP1 1095..1203 CDD:238855
RUN 1376..1436 CDD:214736
DENND3NP_001349727.1 uDENN <122..158 CDD:322520 11/39 (28%)
DENN 185..371 CDD:307995 55/220 (25%)
dDENN 435..497 CDD:129037 15/77 (19%)
WD40 1019..>1120 CDD:330360
WD40 repeat 1028..1063 CDD:293791
WD40 repeat 1067..1108 CDD:293791
WD40 repeat 1114..1152 CDD:293791
WD40 repeat 1160..1196 CDD:293791
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2127
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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