Protein Alignment pns and Dennd5a

DIOPT Version :10

• Sequence 1: NP_647620.1
• Gene: pns / 38178
• FlyBaseID: FBgn0035229
• Length: 1449
• Species: Drosophila melanogaster
• Sequence 2: NP_067469.1
• Gene: Dennd5a / 19347
• MGIID: 1201681
• Length: 1287
• Species: Mus musculus
• Alignment Length: 1509
• Identity: 589/1509 - (39%)
• Similarity: 805/1509 - (53%)
• Gaps: 307/1509 - (20%)

  Fly    21 SGNGSGNGSGPNIQVAPSSTLVQSPTSPGEQSQSQSELNQLKRDADPQFSRFADYFVICGLDLDT 85
            ||.|.|.||.|                                      |||||||||||||.:|
Mouse     2 SGGGGGGGSAP--------------------------------------SRFADYFVICGLDTET 28

  Fly    86 GLEPDRFA------------------------GDNLHCSPLDRAYKSKPLAHYPENVPWNPFDAH 126
            |||||..:                        |:|...:||.|.:|||.||.|||||.|||||..
Mouse    29 GLEPDELSALCQYIQASKARDGASPFISSTTEGENFEQTPLRRTFKSKVLARYPENVDWNPFDQD 93

  Fly   127 GICMLSLPQGLRFRTQKHCIEPRFHSFATTREDGKRCYGFSLVFYEEIRNRNICGAIHTLQSMFI 191
            .:.||.:|:||.|:||....||:||:|..|||||.|.:||:|.||||:.::.||.|:.||..|..
Mouse    94 AVGMLCMPKGLAFKTQADPREPQFHAFIITREDGSRTFGFALTFYEEVTSKQICSAMQTLYHMHN 158

  Fly   192 TE-------LSNGQQTHSLSRVKQDGPVSRSLPRHFKVAGQAPQSAQSYYDINKDKLYVAKSITL 249
            .|       |::|.....:    :||   ..:|      |...|...| |||::|.|||:|.|.|
Mouse   159 AEYDVLHAPLADGGDQSGM----EDG---EGIP------GTKLQRFNS-YDISRDTLYVSKCICL 209

  Fly   250 ICQAPYAFAAQMFLKNLYRCLPRQPGAGISLESYVYNILYEVMLPQPGKSIR---VYLPPTEPHL 311
            |....:..|.:..|:.|::.:.......:.||||:||:||||.||.||:|::   ||.|
Mouse   210 ITPMSFMKACRSVLQQLHQAVTSPQPPPLPLESYIYNVLYEVPLPPPGRSLKFSGVYGP------ 268

  Fly   312 PPIALILQRPLLATELPLLDFPLRLLFKYLGVECVIQLLTCVLLENQVLLRSTDYQRLMIVGECI 376
                :|.||| ...||||.|||::.:|:.||||.|.||.||.|||.|:||.|..|||||.|.|.|
Mouse   269 ----IICQRP-STNELPLFDFPVKEVFELLGVENVFQLFTCALLEFQILLYSQHYQRLMTVAETI 328

  Fly   377 TSLLFPFVWPHVYAPILPAALHHFLDAPVPFVMGLHA---ECEAAHKIGSEATLCFVDIDKKHIQ 438
            |:|:|||.|.|||.|||||:|.||||||||::||||:   :..:..::..||.|||||:|...|:
Mouse   329 TALMFPFQWQHVYVPILPASLLHFLDAPVPYLMGLHSNGLDDRSKLELPQEANLCFVDVDNHFIE 393

  Fly   439 LPEELPVFPHKVDFMAEIGSVLDKFEIERDRDQEPSFRNGYVGRGAGGGVSGSGSSGSGGVDAMI 503
            |||:||.||:|::|:.|:..:|..|                       ||...|:
Mouse   394 LPEDLPQFPNKLEFVQEVSEILMAF-----------------------GVPPEGN---------- 425

  Fly   504 SSCTLPTGLQAARRSKERFQQMQETVYTLSGSPGGGVVDYQPLIAHPSRIDHVPRIADFLRRKGG 568
                |.....|::..:.|..::                                 ::|  :|.|.
Mouse   426 ----LHCSESASKLKRIRASEL---------------------------------VSD--KRNGN 451

  Fly   569 IRGAGSPVGSPTVSLSSSPVGIYHDVDAVDATMPVSTRRAE------KQKLSPVDQYYQDLRI-- 625
            |  ||||:.|..:...:..:.   .:.|:.....||..:.|      ..|...|....::|||
Mouse   452 I--AGSPLHSYELLKENETIA---RLQALVKRTGVSLEKLEVREDPSSNKDFKVQCDEEELRIYQ 511

  Fly   626 -NNSVREIFLNRFVHMFHAYEYFVIYPNQARDEWISNRETLQNFDKSSFLSDQPEHHRAFLSRFL 689
             |..:||:|.|||..||..||.|||.|:|.::.|.:|||.:|||||:||||||||.:..||||||
Mouse   512 LNIQIREVFANRFTQMFADYEVFVIQPSQDKESWFTNREQMQNFDKASFLSDQPEPYLPFLSRFL 576

  Fly   690 ESQMFATLIDNKILAMWESQPDEQLQLFDQRVKLLRRRHGENMIAATS-YEPCVLSQDSQQGFEK 753
            |:||||:.|||||:...:...|..|::||.||..:|..:.......|| |:.|....::::..|.
Mouse   577 ETQMFASFIDNKIMCHDDDDKDPVLRVFDSRVDKIRLLNVRTPTLRTSMYQKCTTVDEAEKAIEL 641

  Fly   754 RLNCIDIEVTPPS--EILANRAAYFRS-FPLLEKGVLNQECASRGNSLR------RVKNGNKWRA 809
            ||..||.....|.  ::...:..|... ||.|:..||....||...:.|      |.|:..|...
Mouse   642 RLAKIDHTAVHPHLLDMKIGQGKYEPGFFPKLQSDVLCTGPASNKWTKRNAPAQWRRKDRQKQHT 706

  Fly   810 REISLDQKPGSNAINRLSANLTT-------ADVSPALIAQANWTFVERLLKDIKSKTKRMLLEKM 867
            ..:.||.......|.. :.|:.:       :::||::|||.||.|||.|||:.::||||||:|||
Mouse   707 EHLRLDNDQREKYIQE-ARNMGSTIRQPKLSNLSPSVIAQTNWKFVEGLLKECRNKTKRMLVEKM 770

  Fly   868 GNEAVALGLKGD----GIEENTLIASMCDLLEKIWSHGLQNKQGKSALWAHLQAYLEMQEARGAG 928
            |.|||.|| .|:    |:||||||||:|||||:|||||||.||||||||:||   |..||.|...
Mouse   771 GREAVELG-HGEVNITGVEENTLIASLCDLLERIWSHGLQVKQGKSALWSHL---LHYQENRQRK 831

  Fly   929 DSSGTEQTPPVSSSPGGKMTIATASPALAWNAMRKRMDYLSTFQTDFDSPPSPNRSRSRDRNKFV 993
            .:||:                                  |||.....||          :|.|..
Mouse   832 LTSGS----------------------------------LSTSGILLDS----------ERRKSD 852

  Fly   994 GLEQLCPLPESLEFDVKNVLAMADIKTHIGYTRAWVRLSLEKKLLSRHFRTLLSDEALLRSLYKR 1058
            ....:.||..||..|::::..:.:|||.:|..|||||||:||||||||.:.||||..|.:.||||
Mouse   853 ASAVMSPLRISLIQDMRHIQNIGEIKTDVGKARAWVRLSMEKKLLSRHLKQLLSDHELTKKLYKR 917

  Fly  1059 SAFLRCEEEKEQFLYHLLTLNTVDYFSFTNIYPTTKLPYRVVIFPSRKYGSYHTSSNVWIMVSGT 1123
            .|||||::||||||||||:.|.||||.|||::.|..:||.::|.||:|.|....::|.||.:||.
Mouse   918 YAFLRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIPYHILIVPSKKLGGSMFTANPWICISGE 982

  Fly  1124 MNETQRVPVPKGSLEFIFHYKNLGLLTTMRIGHDNSGPSHKWLVEQVVMRNEVTGHTYKFPCGRW 1188
            :.|||.:.:|:..||..|..:|||.|||::|||||||...|||||.|::||||||||||||||||
Mouse   983 LGETQILQIPRNVLEMTFECQNLGKLTTVQIGHDNSGLYAKWLVECVMVRNEVTGHTYKFPCGRW 1047

  Fly  1189 LGRGVDDDSTERLLVGQRVLTNAKNAELVPGSDTRTPPRTRSPSV-QRQETLAPS--------EI 1244
            ||:|:||.|.||:|||: :||:....:..|   .||||..:|||| :|..|::|:        :|
Mouse  1048 LGKGMDDGSLERVLVGE-LLTSLPEVDERP---CRTPPLQQSPSVIRRLVTISPNNKPKLNTGQI 1108

  Fly  1245 QHQLGNCVNVLVKWHYKPSRDRDVGTLTNLLCGDDGLVKCLEQVFLCGFRSARFFGRNLYIWDYF 1309
            |..:|..||.:||..:||.::|  |:||.||||:.|||..|||.|..||:|.|.| :|::|||:.
Mouse  1109 QESIGEAVNGIVKHFHKPEKER--GSLTLLLCGECGLVSALEQAFQHGFKSPRLF-KNVFIWDFL 1170

  Fly  1310 TKIKELFEHNLQMELEDSSSSLDSSFSNGSGSGGNSLQRREI--SSIW----RLYVQLMDEINGT 1368
            .|.:..:|                           :|::.::  ...|    |.:.:.:..:|.|
Mouse  1171 EKAQTYYE---------------------------TLEQNDVVPEENWHTRARNFCRFVTAVNNT 1208

  Fly  1369 A--LGKDGKFQLLICLSLREHLLTRLIKPMALTKVTHEMYEEESFLRRRNLLTFLIQILEPLDDC 1431
            .  :|||||||:|:||..|:|||...|..:|...:|..|||:.:.::...|:..||::|:.|.:.
Mouse  1209 PRNIGKDGKFQMLVCLGARDHLLHHWIALLADCPITAHMYEDVALIKDHTLVNSLIRVLQTLQEF 1273

  Fly  1432 HIVLENSITQGIRI 1445
            :|.|:.|:.:||.|
Mouse  1274 NITLDTSLVKGIDI 1287

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pns	NP_647620.1	uDENN	70..171	CDD:214824	61/124 (49%)
		DENN	243..435	CDD:214823	97/197 (49%)
		dDENN	626..701	CDD:129037	46/74 (62%)
		RUN1_DENND5	839..1091	CDD:439039	127/255 (50%)
		PLAT_RAB6IP1	1095..1203	CDD:238855	62/107 (58%)
		RUN2_DENND5	1243..1440	CDD:439040	68/204 (33%)
Dennd5a	NP_067469.1	uDENN	12..138	CDD:214824	62/163 (38%)
		DENN	202..390	CDD:460461	98/198 (49%)
		dDENN	513..588	CDD:129037	46/74 (62%)
		RUN1_DENND5A	742..950	CDD:439052	127/255 (50%)
		PLAT_RAB6IP1	954..1062	CDD:238855	62/107 (58%)
		RUN2_DENND5A	1107..1282	CDD:439054	68/204 (33%)