Protein Alignment pns and DENND5B

DIOPT Version :9

• Sequence 1: NP_647620.1
• Gene: pns / 38178
• FlyBaseID: FBgn0035229
• Length: 1449
• Species: Drosophila melanogaster
• Sequence 2: XP_005253383.1
• Gene: DENND5B / 160518
• HGNCID: 28338
• Length: 1333
• Species: Homo sapiens
• Alignment Length: 1513
• Identity: 595/1513 - (39%)
• Similarity: 821/1513 - (54%)
• Gaps: 294/1513 - (19%)

  Fly    44 SPTSPGEQSQSQSELNQLKRDADPQFSRFADYFVICGLDLDTGLEPDRFA--------------- 93
            |..:||..|.|           .|...|||.|||:||:|.|:|||||..|
Human     4 SCAAPGPGSGS-----------SPAACRFAHYFVLCGIDADSGLEPDELAVLYQWLEADRHGKSQ 57

  Fly    94 -------GDNLHCSPLDRAYKSKPLAHYPENVPWNPFDAHGICMLSLPQGLRFRTQKHCIEPRFH 151
                   |:|...|||.|.:|||.|||||:|:.|||||...:.||.:|:||.||||....:|:||
Human    58 GAANTTSGENFDQSPLRRTFKSKVLAHYPQNIEWNPFDQDAVNMLCMPKGLSFRTQTDNKDPQFH 122

  Fly   152 SFATTREDGKRCYGFSLVFYEEIRNRNICGAIHTLQSMFITE------LSNGQQTHSLSRVKQDG 210
            ||..|||||.|.|||.|.||||:.::.||.|:.||..|...|      .|:.....||:....:|
Human   123 SFIITREDGSRTYGFVLTFYEEVTSKQICTAMQTLYQMHNAEHYSSVYASSSCSMDSLASSLDEG 187

  Fly   211 PVSRSLPRHFKVAGQAPQSAQSY--YDINKDKLYVAKSITLICQAPYAFAAQMFLKNLYRCLPRQ 273
            ..:..|            ..|.|  |||::|.|||:|||.||...|:..|.:.||..||:.:..|
Human   188 DTTSLL------------KLQRYNSYDISRDTLYVSKSICLITPLPFMQACKKFLIQLYKAVTSQ 240

  Fly   274 PGAGISLESYVYNILYEVMLPQPGKSIRVYLPPTEPHLPPIALILQRPLLATELPLLDFPLRLLF 338
            ....:.||||::||||||.||.||:|::.| ...||      :|.||| ..:||||.|:|||..|
Human   241 QPPPLPLESYIHNILYEVPLPPPGRSLKFY-GVYEP------VICQRP-GPSELPLSDYPLREAF 297

  Fly   339 KYLGVECVIQLLTCVLLENQVLLRSTDYQRLMIVGECITSLLFPFVWPHVYAPILPAALHHFLDA 403
            :.||:|.::|:.||||||.|:||.|.||||||.|.|.||:|||||.|.|||.|||||:|.|||||
Human   298 ELLGLENLVQVFTCVLLEMQILLYSQDYQRLMTVAEGITTLLFPFQWQHVYVPILPASLLHFLDA 362

  Fly   404 PVPFVMGLHAECEAAHK----IGSEATLCFVDIDKKHIQLPEELPVFPHKVDFMAEIGSVLDKFE 464
            |||::|||.:: |...:    :..||.|||||||...|:||||.|.||:||||:.|:..||.:|
Human   363 PVPYLMGLQSK-EGTDRSKLELPQEANLCFVDIDNHFIELPEEFPQFPNKVDFIQELSEVLVQF- 425

  Fly   465 IERDRDQEPSFRNGYVGRGAGGGVSGSGSSGSGGVDAMISSCTLPTGLQAARRSKERFQQMQETV 529
                                  |:...||          ..|:..|       ||.:...:::.|
Human   426 ----------------------GIPPEGS----------LHCSEST-------SKLKNMVLKDLV 451

  Fly   530 YTLSGSPGGGVVD-----YQPLIAHPSRIDHVPRIADFLRRKGGIRGAGSPVGSPTVSLSSSPVG 589
               :....|.|..     |:.|..:    :.:.|:....:|.|        |....:.||:|
Human   452 ---NDKKNGNVCTNNISMYELLKGN----ETIARLQALAKRTG--------VAVEKMDLSAS--- 498

  Fly   590 IYHDVDAVDATMPVSTRRAEKQKLSPVDQYYQDLRINNSVREIFLNRFVHMFHAYEYFVIYPNQA 654
                :...|..:.:....||          .:|.::|..:||:|.|||..||..||.|||...|.
Human   499 ----LGEKDKDLKLHCEEAE----------LRDYQLNVQLREVFANRFTQMFADYEAFVIQTAQD 549

  Fly   655 RDEWISNRETLQNFDKSSFLSDQPEHHRAFLSRFLESQMFATLIDNKILAMWESQPDEQLQLFDQ 719
            .:.|::|||.:|||||:||||||||.:..|||||:|:|||||.|||||::.|| :.|..|::||.
Human   550 MESWLTNREQMQNFDKASFLSDQPEPYLPFLSRFIETQMFATFIDNKIMSQWE-EKDPLLRVFDT 613

  Fly   720 RVKLLRRRHGENMIAATS-YEPCVLSQDSQQGFEKRLNCIDIEVTPPS--EILANRAAYFRS-FP 780
            |:..:|..:.......|| |:.|...:::.|..|:||..:|.....|.  ::...:..|.:. ||
Human   614 RIDKIRLYNVRAPTLRTSIYQKCSTLKEAAQSIEQRLMKMDHTAIHPHLLDMKIGQGKYEQGFFP 678

  Fly   781 LLEKGVL------NQECASRGNSLRRVKNGNKWRAREISLD---QKPGSNAI------------- 823
            .|:..||      |....||..:.:|.|...:..:..:.||   ::|....:
Human   679 KLQSDVLATGPTSNNRWVSRSATAQRRKERLRQHSEHVGLDNDLREPSGELLVCQNSMAFWEWDQ 743

  Fly   824 ------------------------NRLSANL---TTADVSPALIAQANWTFVERLLKDIKSKTKR 861
                                    ..|..||   ..:|:|||:|||.|..|||.|||:.:.||||
Human   744 GPPPPARLPKKSFSECCLKYMQEARSLGKNLRQPKLSDLSPAVIAQTNCKFVEGLLKECRMKTKR 808

  Fly   862 MLLEKMGNEAVALGLKGD----GIEENTLIASMCDLLEKIWSHGLQNKQGKSALWAHLQAYLEMQ 922
            ||:||||:|||.|| .|:    |:||||||||:|||||:|||||||.||||||||:||..:.:.:
Human   809 MLVEKMGHEAVELG-HGEANITGLEENTLIASLCDLLERIWSHGLQVKQGKSALWSHLIQFQDRE 872

  Fly   923 EARGAGDSSGTEQTPPVSSSPGGKMTIATASPALAWNAMRKRMDYLSTFQTDFDSPPS--PNRSR 985
            |                                        :.::|:      :||.:  |.|.:
Human   873 E----------------------------------------KQEHLA------ESPVALGPERRK 891

  Fly   986 SRDRNKFVGLEQLCPLPESLEFDVKNVLAMADIKTHIGYTRAWVRLSLEKKLLSRHFRTLLSDEA 1050
            |..     |: .|..|..||..|::::..|::|||.:|..|||:||||||||||:|.:.|||::.
Human   892 SDS-----GV-MLPTLRVSLIQDMRHIQNMSEIKTDVGRARAWIRLSLEKKLLSQHLKQLLSNQP 950

  Fly  1051 LLRSLYKRSAFLRCEEEKEQFLYHLLTLNTVDYFSFTNIYPTTKLPYRVVIFPSRKYGSYHTSSN 1115
            |.:.||||.||||||||:||||||||:||.||||.||:::.|..:|||.||.|.:|..:...:||
Human   951 LTKKLYKRYAFLRCEEEREQFLYHLLSLNAVDYFCFTSVFTTIMIPYRSVIIPIKKLSNAIITSN 1015

  Fly  1116 VWIMVSGTMNETQRVPVPKGSLEFIFHYKNLGLLTTMRIGHDNSGPSHKWLVEQVVMRNEVTGHT 1180
            .||.|||.:.:|..:.:||..||..|..:|||.|||::|||||||...||||:.|::|||:||||
Human  1016 PWICVSGELGDTGVMQIPKNLLEMTFECQNLGKLTTVQIGHDNSGLLAKWLVDCVMVRNEITGHT 1080

  Fly  1181 YKFPCGRWLGRGVDDDSTERLLVGQRVLTNAKNAELVPGSDTRTPPRTRSPSVQRQETLA----- 1240
            |:||||||||:|:||.|.||:|:|: ::|:|.:.:||  ...||||:.:||:..|:.::.
Human  1081 YRFPCGRWLGKGIDDGSLERILIGE-LMTSASDEDLV--KQCRTPPQQKSPTTARRLSITSLTGK 1142

  Fly  1241 -----PSEIQHQLGNCVNVLVKWHYKPSRDRDVGTLTNLLCGDDGLVKCLEQVFLCGFRSARFFG 1300
                 ..:||..:|..||.:||..:||.::|  |:||.||||::|||..|||||..||:|||.|.
Human  1143 NNKPNAGQIQEGIGEAVNNIVKHFHKPEKER--GSLTVLLCGENGLVAALEQVFHHGFKSARIFH 1205

  Fly  1301 RNLYIWDYFTKIKELFEHNLQMELEDSSSSLDSSFSNGSGSGGNSLQRREISSIWRLYVQLMDEI 1365
            :|::|||:..|:...||...|: |::....|              :|:    |..:.:...::.|
Human  1206 KNVFIWDFIEKVVAYFETTDQI-LDNEDDVL--------------IQK----SSCKTFCHYVNAI 1251

  Fly  1366 NGTA---LGKDGKFQLLICLSLREHLLTRLIKPMALTKVTHEMYEEESFLRRRNLLTFLIQILEP 1427
            | ||   :|||||||:|:||..|:.||.:.|..:|.......||||.:.||.|..:..||:||:.
Human  1252 N-TAPRNIGKDGKFQILVCLGTRDRLLPQWIPLLAECPAITRMYEESALLRDRMTVNSLIRILQT 1315

  Fly  1428 LDDCHIVLENSITQGIRI 1445
            :.|..||||.|:.:|:.:
Human  1316 IQDFTIVLEGSLIKGVDV 1333

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pns	NP_647620.1	uDENN	70..171	CDD:214824	60/122 (49%)
		DENN	243..435	CDD:214823	104/195 (53%)
		dDENN	626..701	CDD:129037	45/74 (61%)
		RUN	<989..1083	CDD:295434	52/93 (56%)
		PLAT_RAB6IP1	1095..1203	CDD:238855	60/107 (56%)
		RUN	1376..1436	CDD:214736	24/59 (41%)
DENND5B	XP_005253383.1	uDENN	19..142	CDD:214824	60/122 (49%)
		DENN	209..397	CDD:280329	105/196 (54%)
		dDENN	521..596	CDD:129037	45/74 (61%)
		RUN	839..983	CDD:280855	82/195 (42%)
		PLAT_RAB6IP1	995..1103	CDD:238855	60/107 (56%)
		RUN	1186..1323	CDD:295434	57/156 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	183	1.000	Domainoid score	I3434
eggNOG	1	0.900	-	-		E1_KOG2127
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H44911
Inparanoid	1	1.050	963	1.000	Inparanoid score	I327
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52593
OrthoDB	1	1.010	-	-		D35195at33208
OrthoFinder	1	1.000	-	-		FOG0003741
OrthoInspector	1	1.000	-	-		otm40523
orthoMCL	1	0.900	-	-		OOG6_104889
Panther	1	1.100	-	-	LDO	PTHR46070
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3728
SonicParanoid	1	1.000	-	-		X2599
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.870